Arbutin-modified microspheres prevent osteoarthritis progression by mobilizing local anti-inflammatory and antioxidant responses

Jin, Jiale; Liu, Yang; Jiang, Chao; Shen, Yifan; Chu, Guangyu; Liu, Can; Jiang, Lejian; Huang, Guanrui; Qin, Yifang; Zhang, Yijian; Zhang, Chi; Wang, Yue

doi:10.1016/j.mtbio.2022.100370

Cited by 21 publications

(12 citation statements)

References 53 publications

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“…Jin et al developed a drug-loaded GM-Liposome microsphere to alleviate inflammation and oxidative stress in osteoarthritis. 43 These findings provide us promising applications for targeted therapy to STING/TBK1 in AL.…”

Section: Discussionmentioning

confidence: 84%

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STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis

Ouyang

Liu

et al. 2023

ACS Biomater. Sci. Eng.

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Inflammatory response in macrophages on account of prostheses-derived wear particles is the leading cause of artificial joint failure. However, the mechanism by which wear particles initiate macrophage inflammation has not been fully elucidated. Previous research studies have identified TANK-binding kinase 1 (TBK1) and stimulator of interferon genes (STING) as potential factors in inflammation and autoimmune diseases. Here, we found that both TBK1 and STING were increased in synovium from aseptic loosening (AL) patients and were activated in titanium particles (TiPs)-stimulated macrophages. Lentivirus-mediated knockdown of TBK or STING significantly inhibited the inflammatory effects of macrophages, while overexpression of TBK or STING exerted opposite results. In concrete, STING/TBK1 promoted the activation of NF-κB and IRF3 pathways and macrophage M1 polarization. For further validation, a mice cranial osteolysis model was constructed for in vivo assays, and we found that STING-overexpressed lentivirus injection exacerbated osteolysis and inflammation, which was counteracted by TBK1-knockdown injection. In conclusion, STING/TBK1 enhanced TiP-induced macrophage inflammation and osteolysis via orchestrating the activation of NF-κB and IRF3 pathways and M1 polarization, which suggested STING/TBK1 as potential therapeutic targets for preventing AL of prostheses.

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Section: Discussionmentioning

confidence: 84%

“…Gelatine methacryloyl (GM) is a natural polymer derived from hydrolyzed collagen and is also used as a drug delivery platform. Jin et al developed a drug-loaded GM-Liposome microsphere to alleviate inflammation and oxidative stress in osteoarthritis . These findings provide us promising applications for targeted therapy to STING/TBK1 in AL.…”

Section: Discussionmentioning

confidence: 99%

STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis

Ouyang

Liu

et al. 2023

ACS Biomater. Sci. Eng.

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“…It has been shown from previous studies that liposomes can prolong drug efficacy, improve drug bioavailability, achieve tissue/cell targeting, and also promote lubrication response [ [19] , [20] , [21] , [22] ]. Recently, several liposome formulations of curcumin, rapamycin, and diclofenac sodium have been developed to enhance the inhibition of pro-inflammatory factors for the treatment of osteoarthritis [ [23] , [24] , [25] ].…”

Section: Introductionmentioning

confidence: 99%

Intra-articular treatment of temporomandibular joint osteoarthritis by injecting actively-loaded meloxicam liposomes with dual-functions of anti-inflammation and lubrication

Zhong

Zhou

Ding

et al. 2023

Materials Today Bio

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“…15 Currently, as essential materials for cartilage tissue engineering, Col I and HA have been widely studied, and the main focus is on the effects of their physical properties on cartilage regeneration and the role of composite hydrogels containing anti-inflammatory substances in inflammation and cartilage repair. [12][13][14]16 However, there is a lack of knowledge regarding how the components of Col I and HA hydrogels affect inflammation and cartilage regeneration in vitro and in vivo. Moreover, the response of macrophages to material surface properties has been studied mainly with metals or ceramics.…”

Section: Introductionmentioning

confidence: 99%

Components and physical properties of hydrogels modulate inflammatory response and cartilage repair

Gao,

Dai,

et al. 2023

J. Mater. Chem. B

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Arbutin-modified microspheres prevent osteoarthritis progression by mobilizing local anti-inflammatory and antioxidant responses

Cited by 21 publications

References 53 publications

STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis

STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis

Intra-articular treatment of temporomandibular joint osteoarthritis by injecting actively-loaded meloxicam liposomes with dual-functions of anti-inflammation and lubrication

Components and physical properties of hydrogels modulate inflammatory response and cartilage repair

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