Arboviruses (chikungunya, dengue, and Zika) associated with ophthalmic changes: a focus on aqueous fluid and vitreous humor

Silva, Paulo Alex Neves da; Ito, Célia Regina Malveste; Barbosa, Mônica Santiago; Santos, Mônica de Oliveira; Carneiro, Lí­lian Carla

doi:10.1007/s10096-019-03792-9

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The main form of transmission of CHIKV and ZIKV is the vector pathway, however, in the literature there are cases where transmission occurred through blood transfusion [21] or less frequently by contaminated solid organ transplants [2], in addition to other transmission routes [4].…”

Section: Discussionmentioning

confidence: 99%

“…Brazil is a country of great territorial extension and populous, located in tropical and subtropical regions, in which the presence of mosquitoes of the genus Aedes is frequent [2]. There are no specific treatments and no vaccine against the Chikungunya and Zika viruses [3], in Brazil the use of organs from probable donor, who had recent arbovirus infection, is automatically discarded, since there are no national guidelines recommending the use of same [4]. Even though Brazil is a world reference country in transplants, with 96% of the procedures financed by the Unified Health System in 2018 throughout the country [5] and the second largest country that performs kidney and liver transplants in the world [6].…”

Section: Introductionmentioning

confidence: 99%

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Arbovirus in Transplants of Solid Organs and Eyeball:high Risk in Endemic Area Receptors?/ Arbovírus Em Transplantes De Órgãos Sólidos E Globo Ocular:alto Risco Em Receptores De Área Endêmica?

Carneiro

Silva

2021

BJD

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This work is a retrospective cross-sectional analytical study that evaluated individuals transplanted from solid organs and eye balls that had infection by the Chikungunya or Zika virus and, received the organ from an asymptomatic donor. An epidemiological assessment of infection by the Chikungunya and Zika virus in Brazil, was also carried out, and an assessment of the organ and eyeball transplant situation in Brazil. Other data were obtained from the literature, carrying out a survey of articles published in the PUBMED database, from January 2015 to December 2019, which released data from case reports and retrospective and prospective studies. The symptoms most frequently associated with CHIKV are myalgia (60% -93%), fever above 38.9 ºC (90%) and asymptomatic cases (16% -27%), which are not as frequent, but are relevant when it comes to transplants. Symptoms and signs generally associated with Zika virus infection are skin rashes (91%), fever above 38.9º C (65% -80%), in addition to asymptomatic (80%). We found that recipients of organs contaminated with CHIKV or ZIKV may have different outcomes depending on the transplanted organ. Through this evidence, people who had a recent infection or death from these arboviruses could be candidates for kidney and liver donation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Arbovirus in Transplants of Solid Organs and Eyeball:high Risk in Endemic Area Receptors?/ Arbovírus Em Transplantes De Órgãos Sólidos E Globo Ocular:alto Risco Em Receptores De Área Endêmica?

Carneiro

Silva

2021

BJD

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“…These arboviruses have common and very similar symptoms such as fever, skin rashes, malaise, headache, neutropenia, and lymphopenia. 31…”

Section: Introductionmentioning

confidence: 99%

Post Fever Uveoretinal Manifestations in an Immunocompetent Individual

Sanjay

Agrawal

Mahendradas

et al. 2020

EMJ Allergy Immunol

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Background: Post fever uveoretinal sequelae (PFURS) are the various uveoretinal manifestations seen after a systemic febrile illness in an immunocompetent individual caused by bacteria, viruses, and protozoa. These may be the result of a direct invasion by the pathogen or by indirect mechanism mediated through immune mechanisms. Method: The authors aim to review the ocular manifestations, utility of relevant diagnostic tests, management, and prognosis of PFURS. A comprehensive literature search was conducted on PubMed and Google Scholar databases with the search words “retinitis”, “choroiditis”, “neuroretinitis”, “macular edema”, “maculopathy”, “multifocal retinitis”, “chikungunya”, “dengue”, “West Nile”, “typhoid”, and “rickettsiosis”. Only articles published or translated into English language were considered. The key data were extracted, evaluated, and combined. Results: The authors search yielded 95 articles for the period between 1986 and May 2020. Painless blurring of vision was the most common symptom. Patients can have varied posterior segment manifestations, including vitritis, focal and multifocal patches of retinitis which could be unilateral or bilateral, optic nerve involvement, serous detachment at the macula, macular oedema, and localised involvement of the retinal vessels in the form of beading of the vessel wall, tortuosity, and perivascular sheathing. Conclusion: PFURS presents with a similar morphological pattern irrespective of the aetiology and follows a preset natural course before resolution. Treatment may or may not be required. Treating physicians need to be aware of this important ophthalmic condition even after complete resolution of fever.

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Systemic Viral Infections and the Eye

Barshak

Anesi

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Arboviruses (chikungunya, dengue, and Zika) associated with ophthalmic changes: a focus on aqueous fluid and vitreous humor

Cited by 5 publications

References 35 publications

Arbovirus in Transplants of Solid Organs and Eyeball:high Risk in Endemic Area Receptors?/ Arbovírus Em Transplantes De Órgãos Sólidos E Globo Ocular:alto Risco Em Receptores De Área Endêmica?

Arbovirus in Transplants of Solid Organs and Eyeball:high Risk in Endemic Area Receptors?/ Arbovírus Em Transplantes De Órgãos Sólidos E Globo Ocular:alto Risco Em Receptores De Área Endêmica?

Post Fever Uveoretinal Manifestations in an Immunocompetent Individual

Systemic Viral Infections and the Eye

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