“…Ilex paraguariensis, popularly known as yerba mate, is an arboreal, umbrophilous, and endemic plant; it is an important specie of the Aquifoliaceae family, native to southern Brazil, Paraguay, and northeastern Argentina. The specie distribution coincides mainly with the subtropical Araucaria Forest, covering approximately 540,000 km 2 [11][12][13]. Before being classified by Saint-Hilaire, the plant was already known and used by indigenous people, mainly by the Guaranis in Brazil, with reports since the pre-colonial period Brazilian Archives of Biology and Technology.…”