Aqueous two-phase systems for cephalexin monohydrate partitioning using poly ethylene glycol and sodium tartrate dihydrate: Experimental and thermodynamic modeling

Edrisi, Sanaz; Bakhshi, Hamid; Rahimnejad, Mostafa

doi:10.1007/s11814-019-0256-4

Cited by 10 publications

(6 citation statements)

References 49 publications

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“…18 Several polymer−salt systems have been studied previously, 10,11,19−21 but the role of temperature in these systems is not well investigated. Muniz et al 11 containing PEG, 20,22,23 poly(ethylene glycol) dimethyl ether, 10,19,24,25 and poly(vinylpyrrolidone) (PVP). 26−28 PVP is a low-cost, stable, and water-soluble polymer that has applications in ATPSs to extract or purify the biomolecules.…”

Section: Introductionmentioning

confidence: 99%

“…Muniz et al . studied the phase formation of poly(ethylene glycol) (PEG) with potassium phosphate at T = 298.15 K. In addition, numerous studies are done on the polymer–salt systems containing PEG, ,, poly(ethylene glycol) dimethyl ether, ,,, and poly(vinylpyrrolidone) (PVP). − PVP is a low-cost, stable, and water-soluble polymer that has applications in ATPSs to extract or purify the biomolecules …”

Section: Introductionmentioning

confidence: 99%

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Effect of Temperature on the Phase Equilibria of Poly(vinylpyrrolidone) 10000 + Trilithium Citrate + Water Aqueous Two-Phase System and Partitioning of Curcumin at T = 298.15, 308.15, and 318.15 K

2022

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Curcumin is a natural product traditionally used as a spice that has a great potential for being used as a drug of natural origin. The partitioning of curcumin in an aqueous two-phase system composed of the aqueous solutions of poly(vinylpyrrolidone) 10000 (PVP 10000 ) and trilithium citrate was studied at T = 298.15, 308.15, and 318.15 K. The binodal and tie-line compositions were measured and modeled. The tie-line compositions were modeled successfully using osmotic virial and especially e-Wilson and e-NRTL models, where the deviation percent between the calculated and the experimental tie-line mass fractions was found to be in the range of 0.005−0.03 for the e-Wilson model and 0.02−0.05 for the e-NRTL model, which are in the range of the experimental uncertainties. The high values of the partition coefficient (D) showed the high tendency of curcumin to be extracted from a salt-rich to a polymer-rich phase. The minimum and maximum D values of 11.7 and 21.2 were found at T = 318.15 and 298.15 K, respectively. Moreover, the minimum and maximum extraction efficiencies (E%) of ∼81 and 90% were shown at T = 318.15 and 298.15 K, respectively. Both obtained D and E% values decreased by increasing the temperature, and the best partitioning results were obtained for the tie-lines presented in the middle range of the tie-line compositions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Temperature on the Phase Equilibria of Poly(vinylpyrrolidone) 10000 + Trilithium Citrate + Water Aqueous Two-Phase System and Partitioning of Curcumin at T = 298.15, 308.15, and 318.15 K

2022

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“…The experimental effort can be much reduced with thermodynamic models that are capable to predict the partitioning of different vitamins in ATPS. In previous works, authors tried to describe and correlate partitioning of different compounds in ATPS using models for example, extended Chen‐NRTL, 24 Wilson 25 in PEG–inorganic salt ATPS and with Pitzer model, 26 extended NRTL 27 and modified UNIQUAC 27 in PEG–organic salt ATPS. Also, one model based on Statistical Associating Fluid Theory (SAFT) has been used for the modeling of protein partitioning in PEG–inorganic salt ATPS 28 .…”

Section: Introductionmentioning

confidence: 99%

Partitioning of water‐soluble vitamins in biodegradable aqueous two‐phase systems: Electrolyte perturbed‐chain statistical associating fluid theory predictions and experimental validation

et al. 2020

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Partition coefficients (K) of vitamins (riboflavin, nicotinic acid, nicotinamide, folic acid, cyanocobalamin) in aqueous two‐phase systems (ATPS) composed by polyethylene glycol (PEG 4000, PEG 6000) and organic salt (sodium citrate and sodium tartrate) at T = 298.15 K and p = 1 bar have been studied. Data on liquid–liquid equilibria of the ATPS considered in this study have been taken from the literature (PEG‐Na3Citrate) or measured in this work (PEG‐Na2Tartrate) for PEG 4000 and PEG 6000 at T = 298.15 K and p = 1 bar. The experimental K values were validated by electrolyte perturbed‐chain‐statistical associating fluid theory predictions. The neutral cyanocobalamin has the highest K values among all studied vitamins at any ATPS studied in this work. This finding contrasted with expectations based on literature data which let assume that charged species have typically the highest K values in the considered ATPS. Thus, besides the typically strong charge–charge interactions especially specific forces (e.g., hydrogen bonding) explains the strong PEG‐cyanocobalamin interaction resulting in the high K values.

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“…Material 2b, with the highest FA content and crosslinking degree, exhibited the highest drug load. In this material, PEG‐fraction is predominant, and the interaction between polymer and Cephalexin, by hydrogen bonding should be stronger 34 . Cumulative release profiles show burst phases in all cases, which are clearly more pronounced in the more SA‐rich film (2e).…”

Section: Resultsmentioning

confidence: 87%

“…In this material, PEG-fraction is predominant, and the interaction between polymer and Cephalexin, by hydrogen bonding should be stronger. 34 Cumulative release profiles show burst phases in all cases, which are clearly more pronounced in the more SA-rich film (2e). This effect would be attributed to the higher swelling index of 2e.…”

Section: Radical Crosslinking and Characterization Of Filmsmentioning

confidence: 89%

Fumarate‐co‐PEG‐co‐sebacate photopolymer and its evaluation as a drug release system

Vaillard

Trentino

Navarro

et al. 2022

Journal of Polymer Science

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Fumarate-co-PEG-co-sebacates with different fumaric/sebacic acid ratios are prepared by a simple thermal polycondensation reaction using p-toluensulfonic acid as catalyst. These polymeric precursors are purified by washing with an appropriate organic solvent and the dried materials were photocured to yield elastic films under mild conditions. The properties of polymeric precursors and elastic materials are studied in detail and correlated with fumaric acid/sebacic acid ratios used in the thermal esterification reactions. It is shown that a higher amount of sebacic in the starting polymer leads to softer final film materials, with lower Tg and G' values, which also show higher degradation rates in vitro. Finally, the films are also evaluated as drug release carriers for in vitro release of Cephalexin and Progesterone. The results obtained in these studies indicate that the careful tailoring of the fumaric acid/sebacic acid ratio in the esterification reaction allows to finely tune the thermal, mechanical a degradation properties of the final cross-linked elastic films.

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Aqueous two-phase systems for cephalexin monohydrate partitioning using poly ethylene glycol and sodium tartrate dihydrate: Experimental and thermodynamic modeling

Cited by 10 publications

References 49 publications

Effect of Temperature on the Phase Equilibria of Poly(vinylpyrrolidone) 10000 + Trilithium Citrate + Water Aqueous Two-Phase System and Partitioning of Curcumin at T = 298.15, 308.15, and 318.15 K

Effect of Temperature on the Phase Equilibria of Poly(vinylpyrrolidone) 10000 + Trilithium Citrate + Water Aqueous Two-Phase System and Partitioning of Curcumin at T = 298.15, 308.15, and 318.15 K

Partitioning of water‐soluble vitamins in biodegradable aqueous two‐phase systems: Electrolyte perturbed‐chain statistical associating fluid theory predictions and experimental validation

Fumarate‐co‐PEG‐co‐sebacate photopolymer and its evaluation as a drug release system

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