Aqueous Two-Phase Extraction of Lactic Acid: Optimization by Response Surface Methodology

Aydoğan, Özlem; Bayraktar, Emine; Mehmetoǧlu, Ülkü

doi:10.1080/01496395.2010.550270

Cited by 51 publications

(35 citation statements)

References 23 publications

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“…They achieved an increase of lactate production from 27.8 mM in the first batch to 48.1 mM lactate produced in the fifth batch. In 2011, Aydogan et al [ 96 ] proposed ATPS containing ethanol/dipotassium hydrogen phosphate. The obtained extraction yield for lactic acid achieved a level of 80%.…”

Section: Toxicity Against Microorganismsmentioning

confidence: 99%

Ionic Liquids Toxicity—Benefits and Threats

Flieger

2020

IJMS

194

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Ionic liquids (ILs) are solvents with salt structures. Typically, they contain organic cations (ammonium, imidazolium, pyridinium, piperidinium or pyrrolidinium), and halogen, fluorinated or organic anions. While ILs are considered to be environmentally-friendly compounds, only a few reasons support this claim. This is because of high thermal stability, and negligible pressure at room temperature which makes them non-volatile, therefore preventing the release of ILs into the atmosphere. The expansion of the range of applications of ILs in many chemical industry fields has led to a growing threat of contamination of the aquatic and terrestrial environments by these compounds. As the possibility of the release of ILs into the environment s grow systematically, there is an increasing and urgent obligation to determine their toxic and antimicrobial influence on the environment. Many bioassays were carried out to evaluate the (eco)toxicity and biodegradability of ILs. Most of them have questioned their “green” features as ILs turned out to be toxic towards organisms from varied trophic levels. Therefore, there is a need for a new biodegradable, less toxic “greener” ILs. This review presents the potential risks to the environment linked to the application of ILs. These are the following: cytotoxicity evaluated by the use of human cells, toxicity manifesting in aqueous and terrestrial environments. The studies proving the relation between structures versus toxicity for ILs with special emphasis on directions suitable for designing safer ILs synthesized from renewable sources are also presented. The representants of a new generation of easily biodegradable ILs derivatives of amino acids, sugars, choline, and bicyclic monoterpene moiety are collected. Some benefits of using ILs in medicine, agriculture, and the bio-processing industry are also presented.

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Section: Toxicity Against Microorganismsmentioning

confidence: 99%

Ionic Liquids Toxicity—Benefits and Threats

Flieger

2020

IJMS

194

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“…The final yield recorded was much higher than both the single batch ATPS (35.9 mM lactate) and normal growth medium batch fermentation (38 mM lactate). Later, the use of alcohol/salt ATPS for lactic acid removal was reported by Aydogan et al (2011) . The lactic acid extraction was optimized using a response surface methodology in order to determine the potential of using ethanol/dipotassium hydrogen phosphate for lactic acid recovery.…”

Section: Extractive Fermentation Approaches To Overcome End-product Imentioning

confidence: 99%

“…The partition coefficient and extraction yield of lactic acid was found to be up to 2.06 and 80%, respectively. Despite the suitability of the ATPS method for extractive fermentation of LAB, nonetheless the effectiveness of this method is currently limited by the even lactic acid distribution between two phases ( Wasewar, 2005 ) and the high cost of polymers ( Aydogan et al, 2011 ) make it economically unattractive.…”

Section: Extractive Fermentation Approaches To Overcome End-product Imentioning

confidence: 99%

Extractive Fermentation of Lactic Acid in Lactic Acid Bacteria Cultivation: A Review

et al. 2017

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Lactic acid bacteria are industrially important microorganisms recognized for their fermentative ability mostly in their probiotic benefits as well as lactic acid production for various applications. Nevertheless, lactic acid fermentation often suffers end-product inhibition which decreases the cell growth rate. The inhibition of lactic acid is due to the solubility of the undissociated lactic acid within the cytoplasmic membrane and insolubility of dissociated lactate, which causes acidification of cytoplasm and failure of proton motive forces. This phenomenon influences the transmembrane pH gradient and decreases the amount of energy available for cell growth. In general, the restriction imposed by lactic acid on its fermentation can be avoided by extractive fermentation techniques, which can also be exploited for product recovery.

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“…However, these polymer-based ATPS can be hardly used for large-scale production due to the high cost of polymers and the difficulty in isolating the target compound from the polymer phase (Aydogan, Bayraktar, & Mehmetoglu, 2011) Ethylene oxide-propylene oxide (EOPO) random copolymer is a thermosensitive polymer and capable of separating into two phase at a temperature higher than lower critical solution temperature (LCST) (Johansson, Karlström, & Tjerneld, 1997;Show et al, 2011), and the bottom phase of this two-phase system contains concentrated EOPO. With this property, the phase-forming EOPO in ATPS could be effectively recycled and separated from the target product by heating (Show et al, 2011).…”

Section: Introductionmentioning

confidence: 99%