Aqueous malathion 0.5% as a scabicide: clinical trial.

Burgess, Ian F.; Robinson, Richard; Robinson, John K.; Maunder, John W.; Hassan, Zainudin

doi:10.1136/bmj.292.6529.1172

Cited by 25 publications

(8 citation statements)

References 5 publications

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“…Secondarily infected lesions with nephritogenic streptococci can lead to post-streptococcal glomerulonephritis [1][2][3] and, subsequently, chronic renal disease [4]. Various treatment regimens for scabies have been suggested and tried but more recently, the favoured drugs are aqueous 0 5 % malathion [5] and 5 % monosulfiram soap, the efficacy of which has been recently recommended for use in children and for lactating women [6]. In May 1988, during a study of rapid antigen detection in the diagnosis of group A streptococcal pyoderma in school children [7], a rural school, County Caroni, was found to have children infested with scabies (13-8 %) and infected skin lesions secondary to scabies infestation.…”

Section: Introductionmentioning

confidence: 99%

Scabies infestation: the effect of intervention by public health education

Reid¹,

Thorne²

1990

Epidemiol. Infect.

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SUMMARYThe objectives of this study were to determine the prevalence of scabies in an infested village; to educate the residents on self-treatment and prevention by the use of 5% monosulfiram soap; to evaluate the short term effectiveness of this intervention by determining, 2 weeks later, the compliance to self-treatment and prevention; and to determine the prevalence rate on the second visit. In 59 households (967 % of the village) containing 313 persons, an educational session was held and a leaflet distributed on the use and availability of the soap. Thirteen persons (4-2 %) from eight households (13-6 %) had scabies. After 2 weeks, 7 persons (2-2 %) (2 persisting and 5 new cases) from 5 households (8-5 %) were infested. Thus a cure rate of 85 % was obtained though the prevalence rate showed no statistically significant difference. Among the under 15 year olds, the numbers infected decreased from 10 to 3 while among the over 15 year olds, the numbers infected increased from 3 to 4, neither reading significance at the 5 % level.

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Section: Introductionmentioning

confidence: 99%

Scabies infestation: the effect of intervention by public health education

Reid¹,

Thorne²

1990

Epidemiol. Infect.

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“…Explanation: Despite it being more than 30 years since the trial that initially claimed the efficacy of malathion, there are no malathion RCT in existence . On the other hand, an alert has been issued regarding the purity of malathion…”

Section: Treatment Of Scabiesmentioning

confidence: 99%

Guideline for the diagnosis and treatment of scabies in Japan (third edition)

2017

The Journal of Dermatology

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In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. In this guideline, we introduce criteria for a proper diagnosis of scabies, treatment algorithm for common and crusted (hyperkeratotic) scabies, and prevention. The major change from our second edition is the treatment algorithm. As phenothrin is now available, the first-line therapy for common scabies is either topical phenothrin lotion or oral ivermectin. The second-line option for topical treatment is sulfur-containing ointments, crotamiton cream or benzyl benzoate lotion. γ-Benzene hexachloride ointment is no longer provided for clinical use. In an immunosuppressed patient, the treatment option is still the same, but with close follow up. If the symptoms persist, diagnosis and treatment must be reassessed. For hyperkeratotic scabies and nail scabies, removal of thick crust, cutting of nails and occlusive dressing are additionally required. The safety and effectiveness of combined treatment with topical and oral medications are not yet confirmed. Further assessment is needed. In addition to appropriate treatment, it is essential to educate patients and health-care workers and to conduct epidemiological studies to prevent further spread of the disease through effectively utilizing available resources including manpower, finance, logistics and time.

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“…Secondary infection may manifest itself as folliculitis impetigo, obscuring the primary diagnosis of scabies. 81 Several drugs are available for treatment of scabies in adults. These include malathion, lindane, crotamiton, benzyl benzoate, and the new treatment permethrin.…”

Section: Scabiesmentioning

confidence: 99%