Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients

Funatsu, Hideharu; Yamashita, Hidetoshi; Noma, Hidetaka; Mimura, Tatsuya; Nakamura, Shinko; Sakata, Kumi; Hori, Shingo

doi:10.1007/s00417-004-0950-7

Cited by 259 publications

(202 citation statements)

References 22 publications

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“…24 It has been reported that a vitreous-to-aqueous gradient promotes the anterior diffusion of VEGF, potentially accounting for the occurrence of anterior-segment neovascularisation in conjunction with retinal ischaemia. 4,7 However, it has been unclear whether the aqueous levels of VEGF and IL-6 reflect their vitreous levels. In the present study, we simultaneously measured the cytokine levels in the aqueous humour and vitreous fluid.…”

Section: Discussionmentioning

confidence: 99%

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Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion

Noma

Funatsu

Yamasaki

et al. 2006

Eye

243

174

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Aim To investigate whether the aqueous levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) are correlated to the vitreous levels of these substances and to the severity of macular oedema in branch retinal vein occlusion (BRVO). Methods Aqueous and vitreous samples were obtained during cataract and vitreous surgery from 24 patients (24 eyes) with macular oedema in BRVO. The VEGF and IL-6 levels in aqueous humour, vitreous fluid, and plasma were determined by enzyme-linked immunosorbent assay. The degree of retinal ischaemia was evaluated in terms of the area of capillary nonperfusion using the Scion Image. The severity of macular oedema was evaluated using the OCT. Results The aqueous level of VEGF was significantly correlated with the vitreous level of VEGF (Po0.0001). Vitreous levels of VEGF and IL-6 were significantly correlated with the nonperfusion area of BRVO (Po0.0001, P ¼ 0.0061, respectively), as were the aqueous levels of VEGF and IL-6 (Po0.0001, P ¼ 0.0267, respectively). Furthermore, the vitreous levels of VEGF and IL-6 and the aqueous level of VEGF were significantly correlated with the severity of macular oedema of BRVO (P ¼ 0.0001, P ¼ 0.0331, P ¼ 0.0272, respectively). Conclusion Our results suggest that the aqueous level of VEGF may reflect its vitreous level. Measurement of the aqueous level of VEGF may be clinically useful to indicate the severity of macular oedema with BRVO.

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Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9] VEGF causes conformational alterations, such as phosphorylation and changes in protein content in the tight junctions of retinal vascular endothelial cells, 10,11 which play a role in the increase in vascular permeability. 12 The expression of VEGF is induced by hypoxia in retinal cells 13 and indirectly by IL-6.…”

Section: Introductionmentioning

confidence: 99%

Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion

Noma

Funatsu

Yamasaki

et al. 2006

Eye

243

174

View full text Add to dashboard Cite

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“…At last vitreous and anterior chamber show a positive correlation. [12][13][14][15] However, end of VEGF suppression does not mean the immediate appearance of signs of recurrent CNV activity. The presence of VEGF is necessary but not sufficient for recurrences as other growth factors as well as the complement system have an important role in disease activity.…”

Section: Discussionmentioning

confidence: 99%

Variability of disease activity in patients treated with ranibizumab for neovascular age-related macular degeneration

Enders

Scholz

Muether

et al. 2016

Eye

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Purpose To analyze choroidal neovasularization (CNV) activity and recurrence patterns in patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab, and the correlation with individual intraocular vascular endothelial growth factor (VEGF) suppression time (VST). Methods Post-hoc analysis of data from a prospective, non-randomized clinical study. Patients with nAMD treated with ranibizumab on a pro re nata regimen. Disease activity was analyzed monthly by spectral-domain optical coherence tomography and correlated with VSTs. Results Overall, 73 eyes of 73 patients were included in the study with a mean follow-up of 717 days (range: 412-1239 days). Overall, the mean CNV-activity-free interval was 76.5 days (range: 0-829 days). The individual range of the length of dry intervals was high. A total of 42% of patients had a range of more than 90 days. Overall, 16% of patients showed persistent activity. And 12% stayed dry after the initial ranibizumab treatment. No significant correlation was found between the CNVrecurrence pattern and VST (P = 0.12). Conclusions CNV activity in nAMD is irregular, which is reflected in the range of the duration of dry intervals and late recurrences. The biomarker VST solely seems not to be sufficient to explain recurrence pattern of CNV in all AMD patients.

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“…Согласно наблюде-ниям ряда исследователей, у больных сахарным диабетом (СД), но без признаков диабетической ретинопатии (ДР), регистрируют не высокие, а напротив, низкие уровни VEGF во влаге передней камеры по сравнению с анало-гичным показателем у пациентов, не страдающих СД [27,36,37]. Уровень VEGF во влаге передней камеры коррели-рует с его уровнем в стекловидном теле [38]. Снижение активности VEGF не совсем безопасно для жизнедеятель-ности эндотелиоцитов, перицитов, глиальных клеток и нейронов сетчатки и может привести к усилению апопто-за указанных клеток [39][40][41].…”

Section: вестник офтальмологии 4 2016unclassified

Vascular endothelial growth factors (VEGF): role in pathological processes

2016

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Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients

Abstract: Our results suggest that there is a significant relationship between VEGF and IL-6 levels in aqueous humor and in vitreous fluid. Measurement of the aqueous levels of VEGF and IL-6 may be useful to analyze the pathogenesis of diabetic retinopathy and to predict disease activity.

Cited by 259 publications

References 22 publications

Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion

Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion

Variability of disease activity in patients treated with ranibizumab for neovascular age-related macular degeneration

Vascular endothelial growth factors (VEGF): role in pathological processes

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