Aqueous extracts of the leaves of Sesbania sesban reduces development of diabetic nephropathy in streptozotocin-induced diabetic rat

Abstract

The renal protective effect of the aqueous extract of Sesbania sesban leaves (250 and 500 ing/kg/day) in streptozotocin-induced diabetic rats were studied. Diabetic rats showed severe hyperglycemia with marked^ increase in proteinuria and albuminuria. Thye aqueous extract reduced proteinuria, albuminuria, lipid and glycated hemoglobin (HbAlc) deposition in diabetic rats. Histopathology studies on kidneys of diabetic rats " revealed severe increase in mesangial cells and matrix of glomeruli with hyaline thickening of some arteriole wall, resulted from selective albuminuria and proteinuria. These changes are inhibited by the extract and glibenclamide. These results suggested that aqueous extract of S. sesban has reduced development of diabetic nephropathy in streptozotocin-induced diabetic rats.

Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

“…According to the literature, this plant was used in ancient Indian medicine, where crushed seeds were used to treat boils and inflammations (Olajide et al, 2004). In general, the literature reports its empirical use for diabetes, lipid disorders, diarrhea, ulcers, stomach bleeding, hematuria, rheumatism, asthma, hypertension, pulmonary infections and chronic ophthalmia (Pandhare et al, 2012a;Zeid et al, 2012;Mujahid et al, 2013;Godoi et al, 2014;Moniruzzaman et al, 2015;Dissanayake et al, 2018) and cancer (Lindamulage and Soysa, 2016). Zeid et al (2012) reported its use as a tonic.…”

“…The conclusions of the study exhibited that ethyl acetate fraction and n-butanol fraction of the ethanolic extract can adequately control the blood lipid levels in dyslipidemic situations by interfering with the biosynthesis of cholesterol and utilization of lipids. A study conducted by Pandhare et al (2012a) investigated the antihyperglycemic and antihyperlipidemic effects of A. pavonina seed aqueous extract in rats.…”

“…On the other hand, the LD 50 of the seed aqueous extract of A. pavonina was higher than 2,000 mg/kg (b.w.) when administered orally (Pandhare et al, 2012a). Adedapo et al (2009) observed an absence of toxicity in the kidney, liver, and testes of rats treated with a methanolic extract of the seeds of A. pavonina (200 mg/kg, p.o.).…”

“…This native Asian tree has been naturalized in many parts of the world (Adedapo et al, 2009;Soares et al, 2015). The plant has a long history of traditional medical use for the treatment of many diseases, and its derivatives are used empirically for fever, vomiting, diarrhea, gout, rheumatism, furuncle, hypertension, stomach bleeding, hematuria and cancer (Pandhare et al, 2012a;Godoi et al, 2014;Kuruppu et al, 2019).…”

“…Based on the traditional knowledge of the use of parts of this plant, several pharmacological effects of derivatives have been demonstrated, such as antinociceptive activity of leaf ethanol extract (Moniruzzaman et al, 2015), cytoprotective and antiinflammatory activity of seed extract (Koodalingam et al, 2015); antihyperglycemic and hypolipidemic effect of the aqueous extract of seeds (Pandhare et al, 2012a); antimicrobial and antioxidant activity of bark extracts (Ara et al, 2010b); antifungal activity relates to antimicrobial peptides present in seeds (Soares et al, 2012), among others. Several studies on this species have helped to understand the toxicity and supported its traditional use.…”