Aqueous extract of<i>Paullinia cupana</i>attenuates renal and hematological effects associated with ketoprofen

Belló, Caroline; Prestes, Ana Paula; Schemberger, Josiane Aparecida; Hacke, Ana Carolina Mendes; Pereira, Romaiana Picada; Manente, Francine Alessandra; Carlos, Iracilda Zeppone; Andrade, Cléverton Roberto de; Fernandes, Daniel; Cruz, Ivana Beatrice Mânica da; Unfer, Taís Cristina; Vellosa, José Carlos Rebuglio

doi:10.1111/jfbc.13560

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…In agreement with previously reported results, guarana showed a high antioxidant activity in vitro [41][42][43][44][45][46]. It is not surprising that the radical scavenging capacity of the extract was so high, given the known hydrogen and electron-donating ability of polyphenols [47].…”

Section: Discussionsupporting

confidence: 92%

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

et al. 2022

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Guarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence. However, its indirect health impacts through the gut microbiota have not been studied. Caenorhabditis elegans is a useful model to study both the direct and indirect effects of nutraceuticals, as the intimate association of the worm with the metabolites produced by Escherichia coli is a prototypic simplified model of our gut microbiota. We prepared an ethanoic extract of guarana seeds and assessed its antioxidant capacity in vitro, with a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and in vivo, utilizing C. elegans. Additionally, we studied the impact of this extract on C. elegans lifespan, utilizing both viable and non-viable E. coli, and assessed the impact of guarana on E. coli folate production. The extract showed high antioxidant capacity, and it extended worm lifespan. However, the antioxidant and life-extending effects did not correlate in terms of the extract concentration. The extract-induced life extension was also less significant when utilizing dead E. coli, which may indicate that the effects of guarana on the worms work partly through modifications on E. coli metabolism. Following this observation, guarana was found to decrease E. coli folate production, revealing one possible route for its beneficial effects.

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Section: Discussionsupporting

confidence: 92%

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

et al. 2022

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“…Due to the high procyanidin contents in the herbal matrices, the DPPH assay was selected for the evaluation of the antioxidant activity. The results of all the matrices are reported in [116] were significantly higher in our study compared to the literature data. The comparison with literature data is summarized in Table 7.…”

Section: Antioxidant Activitycontrasting

confidence: 76%

Optimization and Validation of Procyanidins Extraction and Phytochemical Profiling of Seven Herbal Matrices of Nutraceutical Interest

Keivani,

Piccolo,

Marzocchi

et al. 2024

Antioxidants

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Several medicinal herbal plants are extensively used as sources of bioactive compounds with beneficial effects on human health. This study assessed the procyanidin and polyphenol profiles together with the antioxidant potential of seven herbal medical matrices. To achieve this aim, procyanidin extraction from grape pomace was optimized and validated by monitoring monomeric-trimeric procyanidins. The proposed quantification method was applied to the seven medical herbs, and it proved to be a very efficient protocol for procyanidin-rich extracts analysis. In addition, the Paullinia cupana Kunth. seed was identified as a very rich source of procyanidins (about 5 mg/g dry matrix of each dimeric and about 3 mg/g dry matrix trimeric) with high antioxidant properties. The polyphenolic profile was assessed by HPLC-HESI-MS/MS analysis. The in vitro antioxidant activity was evaluated by DPPH assay to explore the antioxidant properties of the extracts, which were substantially higher in Peumus boldus Molina leaves extracts (935.23 ± 169 μmol of Trolox equivalent/g of dry weight) concerning the other matrices. Moreover, a high Pearson coefficient value was observed between the total flavonoid content (TFC) and DPPH in comparison with the total polyphenol content (TPC) and DPPH, indicating flavonoids as the principal bioactive with antioxidant activity in the extracts.

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“…Studies demonstrated a half‐maximal effective concentration value (sample concentration providing 50% of antioxidant activity) for seed extracts of Eugenia involucrata (33.6 μg/ml) (Girardelo et al, 2020), aqueous extract of Paullinia cupana (17.0 μg/ml) (Belló et al, 2021), seeds of Euterpe oleracea (8.8 μg/ml) (Barros et al, 2015), and fruit pulp extracts of Caryocar villosum (7.81 μg/ml) (Yamaguchi et al, 2017). Our results showed a significant effect (40% inhibition with 0.1 mg/ml of the P. trifoliata extract), similar to the effect of 0.5 μg/ml of ascorbic acid used as a positive control.…”

Section: Discussionmentioning

confidence: 99%

Piranhea trifoliata extracts ameliorate muscular decline in Drosophila melanogaster exposed to Paraquat

Alencar

Costa

Lisboa

et al. 2022

Arch Insect Biochem Physiol

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In this study, we have demonstrated, for the first time, the muscular protective effects of Piranhea trifoliata bark extract against Paraquat (PQ)‐induced oxidative stress in Drosophila melanogaster. Exposure of D. melanogaster (Canton Special) to PQ caused oxidative stress, as evidenced by protein carbonyl and elevated acetylcholinesterase (AChE) activity levels. However, a diet supplemented with the P. trifoliata extracts (0.1 mg/ml) for 10 days ameliorates protein carbonyl levels and enzymatic activities of AChE and citrate synthase to prevent PQ damage. Also, P. trifoliata bark extracts showed in phytochemical assays the presence of phenols, at 46.06 mg EAG/g extract of total phenolic compounds, and a 40% 2,2‐diphenyl‐1‐picryl‐hydrazyl scavenging effect. The study showed the muscular protective function of the P. trifoliata extracts in D. melanogaster exposed to PQ. On the basis of the results, we contemplate that the bark of P. trifoliata might prevent and ameliorate human diseases caused by oxidative stress. The muscular action of the P. trifoliata extract can be attributed to the antioxidant constituents, while the precise mechanism of its action needs further investigation.

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Aqueous extract ofPaullinia cupanaattenuates renal and hematological effects associated with ketoprofen

Cited by 5 publications

References 64 publications

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans

Optimization and Validation of Procyanidins Extraction and Phytochemical Profiling of Seven Herbal Matrices of Nutraceutical Interest

Piranhea trifoliata extracts ameliorate muscular decline in Drosophila melanogaster exposed to Paraquat

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