Aqueous extract of Forsythia viridissima fruits: Acute oral toxicity and genotoxicity studies

Acute oral toxicity of a novel functional drink based on Ilex guayusa, Vernonanthura patens, and cocoa husk

“…Since herbal preparations are composed of multiple bioactive phytochemicals with various therapeutic activities, their combination can be beneficial to treat or prevent several diseases such as cancer, chronic diseases, and metabolic syndrome diseases. Identification and scientific validation of plants with pharmacological activity is the main objective of medicinal plant research [ 4 ]. Ilex guayusa is a native Amazonian plant which is mainly consumed for its stimulant, diuretic, anti-inflammatory, and gastroprotective properties [ 10 ].…”

“…420 of the Organization for Economic Cooperation and Development [ 20 ]. The mice were randomly distributed in three groups of five animals each, and before dosing the treatments, they fasted for four h with free access to water [ 4 ]. Subsequently, body weights were recorded (UW8200S scale, Shimadzu®, Kioto, Japan), and then the treatments were dosed orally with the help of an oral-esophageal cannula.…”

“…Herbal medicine consumption to treat various health ailments has been utilized for centuries up to the present time [ 3 ]. Although natural medicine is commonly thought to be safe due to its long-term use, it can also be detrimental to human health at the wrong doses [ 4 ]. Since the number of natural and medicinal plant-based preparations has grown exponentially worldwide, toxicological studies are an absolute requirement to prevent adverse toxicity and determine a safe dose range for human consumption [ 4 ].…”

Toxicity as prime selection criterion among SARS-active herbal medications

“…Studies in rats and mice on Forsythia and its major bioactive constituent forsythin did not show toxicities ( Shin et al, 2020 ; Han et al, 2017 ). Several in vivo and in vitro tests showed no genotoxicity ( Shin et al, 2020 ).…”

Mutagenic and teratogenic toxicity evaluation of Forsythia suspensa leaves aqueous extract

“…Moreover, a daily dose of ethyl acetate extract of FSL (500 mg/kg body weight) significantly reduced the serum levels of triglyceride and low-density lipoprotein cholesterol in hyperlipidemic mice, suggesting the in vivo hypolipidemic activity. Apart from these, FSL also have anti-viral, anti-inflammatory, liver protection, and cardiovascular/cerebrovascular benefits (Chen et al 2018;Xu et al 2019;Shin et al 2020). Therefore, it is vital to conduct the safety assessment experiments for the medicinal usage of FSL.…”