Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Abstract

Objective: To investigate Cyperus esculentus aqueous extract on paroxetine-mediated sexual dysfunction in male Wistar rats. Methods: Sexually dysfunctioned (SD) rats were orally treated with PowMaxM [reference drug (7.14 mg/kg)] and the extract (500 and 1000 mg/kg body weight) once daily for 10 days, and their sexual behavioural parameters were monitored and computed. Relative testes-body weight and testicular function parameters were also evaluated at the end of the treatment period. Results: Dim light observation on the animals revealed respective proceptive and precopulatory behaviours by the primed female animals and the extract-treated male rats. Compared with SD rats, the extracttreated groups significantly restored and improved sexual behaviour and libido as evident from the remarkably increased frequencies of mount, intromission, ejaculation and ejaculatory latency. In addition, the latencies of mount, intromission, and post-ejaculation were significantly reduced. The significantly reduced testicular activities of alkaline phosphatase, acid phosphatase, lactate dehydrogenase and the concentrations of protein, cholesterol, glycogen, testosterone, luteinizing hormone, follicle stimulating hormone and testes-body weight in the SD rats were also markedly increased following treatment with the extract. The effects elicited by the extract competed favourably with the reference drug used. The improved sexual competences exhibited by the male rats in this study are indicative of aphrodisiac attributes of the extract and could be adduced to the presence of phytonutrients as revealed by the GC-MS chromatogram. Conclusion: The data from this study suggest that C. esculentus is capable of restoring and boosting sexual competence and the probable mechanism is via synergistic influence of the adaptogenic bioactive principles.

KINETICS OF MODULATORY ROLE OF Cyperus esculentus L. ON THE SPECIFIC ACTIVITY OF KEY CARBOHYDRATE METABOLIZING ENZYMES

“…Besides being consistent with previous in vitro studies ( Overall, the effects elicited by CEE in this study could be ascribed to its minerals and phytonutrients which are known for their antidiabetic attributes. Besides containing tannins, alkaloids and saponins [whose antidiabetic potentials in aiding regeneration of pancreatic β-cells and inhibition of the specific activities of α-glucosidase and α-amylase have been reported (Kunyanga et al, 2011;Zheng et al, 2011;Madhusudhan and Kirankumar, 2015)], previous report on the GCMS analysis of CEE also revealed rotundiene (0.87%), taxol (0.32%), camptothecin (1.12%), morphine (1.36%), allicin (1.11%), viblastine (5.24%), isokobosone (5.33%), tubocurrarine (5.43%), capscicine (6.79%), p-cymol (7.34%), vincristine (7.64%) and digoxigenin (8.11%) as its major adaptogenic constituents (Sabiu et al, 2016a). These compounds have been implicated either as ROS scavengers or hypoglycemic agents (Harikesh et …”

Brysocarpus coccineus(Schum & Thonn) root reinstates sexual competence and testicular function in paroxetine-induced sexual dysfunction in male Wistar rats

“…Paroxetine‐induced sexual dysfunction model was used in the present investigation because of its wide acceptability for studying the potency of medicinal plants and its natural products (Ajiboye, Nurudeen, & Yakubu, ; Allouh, Daradka, Al Barbarawi, & Mustafa, ; Malviya, Jain, Gupta, & Vyas, , ; Sabiu, Ajani, Bamishile, & Yinusa, ). Similarly, Powmax M was also adopted as a positive control in the current investigation because apart from being one of the pharmacologically approved herbal drugs in Nigeria that has brought relief to some of the inhabitants on cases relating to sexual dysfunction, it is a non‐orthodox herbal drug that has been reported to restore all the components of sexual activity in male rats (Ajiboye et al., ; Kayode & Yakubu, ; Sabiu et al., ). In addition, the use of Powmax M in this study will form the basis of comparing the efficacy of the extract of B. coccineus root with a polyherbal formulation.…”

Aqueous Extract of Cyperus esculentus L. (Cyperaceae) Enhances Libido and Spermatogenesis in Male Wistar Rats

“…Though, mount frequency points at sexual motivation, improved ejaculatory latency displays the comfort by which ejaculatory reflexes are maintained. 16 Hence, the dose-dependent activities of mount frequency and ejaculatory latency after exposure to tiger nut are indicative of increased libido. 17 Such increment may result from increased levels of anterior pituitary hormones and testosterone, which subsequently inspired sexual competency by intensive stimulation from dopamine receptors.…”

“…17 Such increment may result from increased levels of anterior pituitary hormones and testosterone, which subsequently inspired sexual competency by intensive stimulation from dopamine receptors. 16 The mechanism of action has not been fully established but is said to arise primarily from increased amount of blood flow to the erectile muscles thereby increasing the testosterone levels. 15 However, the role of testosterone in the improvement of sexual behavior was not investigated in this study.…”