Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice

White, Pollyanna Alves Secundo; Cercato, Luana Mendonça; Batista, Vanessa Soares; Camargo, Enilton A.; Lucca, Waldecy de; Oliveira, Alan Santos; Silva, F.T.; Goes, Tiago Costa; Oliveira, Édica Ramone Andrade; Moraes, Valéria R. S.; Nogueira, Paulo C.L.; Silva, A.M. De Oliveira e; Quintans‐Júnior, Lucindo José; Lima, Bruno S.; Araújo, Adriano A. S.; Santos, Márcio Roberto Viana dos

doi:10.1016/j.jep.2015.12.047

Cited by 33 publications

(31 citation statements)

References 46 publications

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“…The mass spectrum of peak 6 displayed precursor ion [M − H] − at m/z 493 (100%), indicating that molecular mass was 494 amu for compound 6. MS/MS analysis showed the fragment ion at m/z 317 (100%) corresponding to the loss of glucuronic acid (176 amu), similar mass fragmentation pattern to flavonoid myricetin 3-O-glucuronide, which has already been identified in previous reports in the hydroalcoholic and aqueous extracts of C. icaco leaf [4,5].…”

Section: Characterization Of the Three Major Peakssupporting

confidence: 72%

“…The appropriate UHPLC-DAD parameters were optimized by univariate procedures taking as starting the conditions reported in the literature for HPLC study of C. icaco [4,5]. Thus, to improve the chromatographic performance, the influence of flow rate was examined from 0.2 to 0.35 mL/min with the column temperature maintained at 30°C, and the column temperature was investigated from 25 to 35°C at the flow rate of 0.3 mL/min.…”

Section: Optimization Of Chromatographic Methodsmentioning

confidence: 99%

“…Flavonoids and their glycosides, particularly derivatives of myricetin, can be considered as chemotaxonomic markers for the Chrysobalanaceae family [19,42,43]. Barbosa et al [4] identified in the tincture of C. icaco leaf the presence of myricetin 3-O-glucuronide as the major constituent, myricitrin, rutin, and quercitrin, even as other myricetin and quercetin derivatives; as well as White et al [5] confirmed the presence of the same phenolic compounds in the aqueous extract of C. icaco leaf.…”

Section: Characterization Of the Three Major Peaksmentioning

confidence: 99%

“…The antidiabetic effect of C. icaco extracts has been investigated , as well as its anti‐inflammatory and antinociceptive , antileishmanial , antioxidant , genotoxic , antimicrobial , anti‐HIV , antiangiogenic , anti‐cancer and anti‐multidrug resistance properties and for preventing weight gain . Phytochemical studies have also reported the presence of flavonoids and terpenoids, which are pharmacologically important chemical groups .…”

Section: Introductionmentioning

confidence: 99%

“…flavonoids and terpenoids, which are pharmacologically important chemical groups [4,5,10,12,14,15,18,19].…”

mentioning

confidence: 99%

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Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

et al. 2017

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We investigated a strategy for the chemotaxonomy study of Chrysobalanus icaco Linnaeus (Chrysobalanaceae) based on ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis. Two models using principal component analysis and partial least squares discriminant analysis were developed, and the samples could be successfully classified into two classes: Class 1 (red morphotype) and Class 2 (white and black morphotypes). Furthermore, ultra-high performance liquid chromatography coupled with diode array and electrospray ionization tandem mass spectrometry was used to identify the main compounds responsible for class separation. The partial least squares discriminant analysis model accurately classified the C. icaco samples using an external validation subset with prediction ability of 100% and revealed the existence of two chemotypes. The most important finding obtained in this study is that the three morphotypes distinguished by the mature fruit color (white, red, and black) are not all phytoequivalent to each other.

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Section: Characterization Of the Three Major Peakssupporting

confidence: 72%

Section: Optimization Of Chromatographic Methodsmentioning

confidence: 99%

Section: Characterization Of the Three Major Peaksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…flavonoids and terpenoids, which are pharmacologically important chemical groups [4,5,10,12,14,15,18,19].…”

mentioning

confidence: 99%

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Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

et al. 2017

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Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin

Chen

Sun

et al. 2022

Phytotherapy Research

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Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, antimicroorganisms, immunomodulation, analgesia, wound healing, and vasodilation.Based on these various pharmacological activities, increasing studies have focused on the potency of quercitrin in diverse diseases in recent years, such as bone metabolic diseases, gastrointestinal diseases, cardiovascular and cerebrovascular diseases, and others. In this paper, by collecting and summarizing publications from the recent years, the natural sources, pharmacological activities and roles in various diseases, pharmacokinetics, structure-activity relationship, as well as the toxicity of quercitrin were systematically reviewed. In addition, the underlying molecular mechanisms of quercitrin in treating related diseases, the dose-effect relationships, and the novel preparations were discussed on the purpose of broadening the application prospect of quercitrin as functional food and providing reference for its clinical application.Notably, clinical studies of quercitrin are insufficient at present, further high-quality studies are needed to firmly establish the clinical efficacy of quercitrin.

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Proteomics Response of Medicinal Plants to Salt Stress

Sunil,

Sadashivaiah,

Chandrakanth

et al. 2023

Stress-Responsive Factors and Molecular Farming in Medicinal Plants

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Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice

Cited by 33 publications

References 46 publications

Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin

Proteomics Response of Medicinal Plants to Salt Stress

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