Aqueous extract of Carpolobia lutea root ameliorates paroxetine-induced anti-androgenic activity in male rats

Yakubu, Musa Toyin; Jimoh, Rukayat Oluwatoyin

doi:10.1016/j.mefs.2014.10.001

Cited by 22 publications

(7 citation statements)

References 31 publications

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“…Apart from its inhibitory effect on nitric oxide synthase activity that prevents ejaculation and abolishes orgasm, paroxetine has also been reported to selectively inhibit the specific activities of ALP, ACP and LDH in the testes [41]. Testicular ALP and ACP are important enzymes involved in steroidogenesis by respectively partaking in channelizing materials for the process and maintenance of sperm physiology [42].…”

Section: Treatmentsmentioning

confidence: 99%

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Sabiu¹,

Ajani²,

Temitope³

et al. 2016

J Exp Integr Med

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Objective: To investigate Cyperus esculentus aqueous extract on paroxetine-mediated sexual dysfunction in male Wistar rats. Methods: Sexually dysfunctioned (SD) rats were orally treated with PowMaxM [reference drug (7.14 mg/kg)] and the extract (500 and 1000 mg/kg body weight) once daily for 10 days, and their sexual behavioural parameters were monitored and computed. Relative testes-body weight and testicular function parameters were also evaluated at the end of the treatment period. Results: Dim light observation on the animals revealed respective proceptive and precopulatory behaviours by the primed female animals and the extract-treated male rats. Compared with SD rats, the extracttreated groups significantly restored and improved sexual behaviour and libido as evident from the remarkably increased frequencies of mount, intromission, ejaculation and ejaculatory latency. In addition, the latencies of mount, intromission, and post-ejaculation were significantly reduced. The significantly reduced testicular activities of alkaline phosphatase, acid phosphatase, lactate dehydrogenase and the concentrations of protein, cholesterol, glycogen, testosterone, luteinizing hormone, follicle stimulating hormone and testes-body weight in the SD rats were also markedly increased following treatment with the extract. The effects elicited by the extract competed favourably with the reference drug used. The improved sexual competences exhibited by the male rats in this study are indicative of aphrodisiac attributes of the extract and could be adduced to the presence of phytonutrients as revealed by the GC-MS chromatogram. Conclusion: The data from this study suggest that C. esculentus is capable of restoring and boosting sexual competence and the probable mechanism is via synergistic influence of the adaptogenic bioactive principles.

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Section: Treatmentsmentioning

confidence: 99%

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Sabiu¹,

Ajani²,

Temitope³

et al. 2016

J Exp Integr Med

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“…In accordance with our indings Yakubu and Jomih ( 2014) have reported increases in the levels of serum urea, uric acid and creatinine after the administration of paroxetine at the dose of 10mg/kg for 5 and 21 days. So, signi icant increases in serum ASAT and ALAT were observed by Elmelegy and Kamal (2013) when the rats had received paroxetine intraperitoneally (1mg/kg) and/or orally (10 mg/kg) for 21 days Yakubu and Jomih (2014) have shown in the testes a reduction in the level of proteins, glycogen, and cholesterol as well in the activities of alkaline phosphatase, acid phosphatase, lactate dehydro-genase and gamma-glutamyl transferase after the administration of paroxetine at the dose of 10mg/kg for 21 days. These parameters are biomarkers of the normal function of testes as an energy source, maturation substrate and transfer of androgen and consequently regulation of spermatogenesis.…”

Section: Discussionmentioning

confidence: 90%

Effects of paroxetine on biochemical parameters and reproductive function in male rats

Mosbah

Chettoum

Mantovani

2021

ijrps

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Selective serotonin reuptake inhibitors (SSRI) are a class of molecules used in treating depression, anxiety, and mood disorders. Paroxetine (PRT) is one of the most prescribed antidepressants, which has attracted great attention regarding its side effects in recent years. This study was planned to assess the adverse effects of paroxetine on the biochemical parameters and reproductive system. Fourteen male Wistar rats were randomly allocated into two groups (7 rats for each): control and treated with paroxetine at a dose of 5mg/kg.bw for two weeks. At the end of the experiment, blood was collected from the retro-orbital plexus for measuring the biochemical parameters, whereas the reproductive organs were removed for measuring semen quality and the histological investigations. Results showed that paroxetine induced significant changes in some biochemical parameters and alteration of semen quality, including sperm count, spermatids number and sperm viability, motility and abnormalities. The histopathological examinations of testis and epididymis revealed an alteration of spermatogenesis, cellular disorganization and vacuolization, enlargement of interstitial space, shrinkage and degenerative changes in the epithelium of seminiferous and epididymal tubules with few to nil numbers of spermatozoa in their lumen. In conclusion, paroxetine treatment caused changes in some biochemical parameters and sperm profiles as well as histopathologic effects of reproductive organs.

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“…It exists in various types of germ cells. Its content and vitality are the highest in sperm, affecting sperm synthesis and release, energy metabolism, and fertilization [61]. PRX significantly reduced the LDH activity in the testis of male mice, thereby reducing sperm synthesis and fertilization ability.…”

Section: Discussionmentioning

confidence: 99%

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Huang,

Wu,

Qin

2023

Foods

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Pfaffia glomerata extract (PGE) has a variety of biological activities. However, its ameliorative effect on and exact working mechanism in male sexual dysfunction are still poorly understood. This study aims to evaluate the ameliorative effect of PGE on paroxetine (PRX)-induced sexual dysfunction in male mice and uses molecular docking technology to investigate its underlying mechanism. In this work, PRX-induced sexual dysfunction was caused and PGE was gavaged in mice for 28 days. The results show that PGE significantly improved the sexual performance of mice and reduced the damage to testicular tissues. Further studies showed that PGE restored serum sex hormones to normal levels and increased nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) levels as well as nitric oxide synthase (NOS) activity in penile tissues, while also decreasing phosphodiesterase-5 (PDE-5) activity, thereby maintaining normal penile erection in mice. In addition, PGE improved the activities of enzymes (LDH, ACP, and ALP) related to energy metabolism in the testis and significantly increased sperm count and viability in mice. Furthermore, the molecular docking results show that all eight compounds in PGE could form a stable complex with PDE-5 and inhibit the activity of PDE-5. In conclusion, PGE had an ameliorative effect on PRX-induced sexual dysfunction, suggesting that PGE has a potential protective effect on male sexual health.

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Aqueous extract of Carpolobia lutea root ameliorates paroxetine-induced anti-androgenic activity in male rats

Cited by 22 publications

References 31 publications

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Effects of paroxetine on biochemical parameters and reproductive function in male rats

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

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