Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation

Han, Jong-Min; Kim, Hyeong-Geug; Choi, Min‐Kyung; Lee, Jin-Suk; Park, Hye-Jung; Wang, Jinghua; Lee, Jong-Suk; Son, Seung-Wan; Hwang, Seock-Yeon; Son, Chang‐Gue

doi:10.1016/j.fct.2012.07.018

Cited by 32 publications

(30 citation statements)

References 49 publications

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“…The herb Artemisia iwayomogi is frequently used to treat 'dampness and phlegm' in TKM, and also exerts effects against hyperlipidemia and obesity (Choi et al, 2013;Han et al, 2012). Another herb, Curcuma longa radix, the therapeutic and anti-hyperlipidemic properties of which are well-documented, has been used to cure pathological 'blood stasis' (Jang et al, 2008;Manjunatha and Srinivasan, 2007;Yiu et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model

Han

Lee

Kim

et al. 2015

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 98%

Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model

Han

Lee

Kim

et al. 2015

Journal of Ethnopharmacology

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“…Several studies have demonstrated that AI contains flavonoids such as genkwanin and jaceosidin [43], essential oils, including eugenol and 1,8-cineole [44], and coumarin compounds such as scopoletin and scopolin [43, 45]. In addition, scopoletin has been used as a standard compound for the verification and identification of AI [46, 47]. In the present study, we isolated not only scopoletin, but also scopolin and acetophenone glycoside from the AI extract (Figure 1 and Table 2).…”

Section: Discussionmentioning

confidence: 99%

Artemisia iwayomogiExtract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Choi

Yanagawa

Kim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The objective of the present study was to determine whether Artemisia iwayomogi (AI) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (HFD), and if so, whether these effects are exerted by modulation of the expression of genes associated with adipogenesis and inflammation. AI extract supplementation for 11 weeks significantly prevented HFD-induced increments in body weight, visceral adiposity, adipocyte hypertrophy, and plasma levels of lipids and leptin. Additionally, AI extract supplementation resulted in downregulation of adipogenic transcription factors (PPARγ2 and C/EBPα) and their target genes (CD36, aP2, and FAS) in epididymal adipose tissue compared to the HFD alone. The AI extract effectively reversed the HFD-induced elevations in plasma glucose and insulin levels and the homeostasis model assessment of insulin resistance index. Furthermore, the extract significantly decreased gene expression of proinflammatory cytokines (TNFα, MCP1, IL-6, IFNα, and INFβ) in epididymal adipose tissue and reduced plasma levels of TNFα and MCP1 as compared to HFD alone. In conclusion, these results suggest that AI extract may prevent HFD-induced obesity and metabolic disorders, probably by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.

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“…Therefore, the 70% MeOH extract from A. iwayomogi would be more suitable as a potent peroxynitrite scavenger than the other extracts tested. This extract could prevent atherosclerosis (Heeba et al, 2009) and hepatic (Han et al, 2012;Wang et al, 2012) or bowel (Singer et al, 1996) diseases that can be mediated through the excess production of peroxynitrite. The MeOH extract was prepared on a large scale, using the reflux method.…”

Section: Optimization and Validation Of The Hplc Methodsmentioning

confidence: 99%

“…It has been pharmacologically reported mainly by Korean researchers that A. iwayomogi inhibits adipogenesis, osteoporosis, hepatic fibrosis, allergy, and inflammation Ding et al, 2010;Han et al, 2012;Shin et al, 2006). In particular, scopoletin and scopolin inhibit osteoporosis by scavenging reactive oxygen species (Lee et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification and validation of new peroxynitrite scavengers fromArtemisia iwayomogi

Nugroho

Lim

Karki

et al. 2014

Pharmaceutical Biology

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Context: Artemisia iwayomogi Kitamura (Compositae) has been very widely used for the treatment of acute or chronic hepatitis, jaundice, and gastritis. In the course of our continuing efforts to identify and quantify peroxynitrite scavengers from Compositae plants, A. iwayomogi was used in this study. Objective: The present study was aimed to identify and quantify the peroxynitrite scavengers of A. iwayomogi. Materials and methods: Silica gel and ODS were used for column chromatography. The isolated compounds were quantified using an HPLC equipped with a Capcell Pak C18 column (5 mm, 250 mm Â 4.6 mm i.d.), and the method was validated for the quality control. Peroxynitrite (ONOO À )-scavenging activities of the compounds and extracts were evaluated on the measurement of highly fluorescent rhodamine 123 converted from non-fluorescent dihydrorhodamine (DHR)-123 under the presence of peroxynitrite. Results: Based on the spectroscopic evidences, a new compound, 2 00 -O-caffeoylrutin (2 00 -O-trans-caffeic acid ester of quercetin 3-O-a-L-rhamnopyranosyl(1 ! 6)-b-D-glucopyranoside) was isolated and determined together with patuletin 3-O-glucoside, scopolin, scopoletin, rutin, 3,4-dicaffeoylquinic acid, and chlorogenic acid. All of them were potent peroxynitrite scavengers (IC 50 1.88 mg/mL). Discussion and conclusion: The peroxynitrite scavengers were mainly distributed in the EtOAc fraction rather than the ether and BuOH fractions. The 70% MeOH extract exhibited a high peroxynitrite-scavenging activity. Through the validation, the present HPLC method was verified to be sufficiently sensitive, accurate, precise, and stable. Therefore, this method can be used for the quality control of A. iwayomogi.

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Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation

Cited by 32 publications

References 49 publications

Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model

Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model

Artemisia iwayomogiExtract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Simultaneous quantification and validation of new peroxynitrite scavengers fromArtemisia iwayomogi

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