Aqueductal stenosis following mumps virus infection. Case report

Rotilio, Antonino; Salar, G; Dollo, Carmen; Öri, C.; Carteri, A

doi:10.1007/bf02229199

Cited by 16 publications

(4 citation statements)

References 10 publications

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“…There have so far been no apparent clinical cases in which congenital hydrocephalus was produced by intrauterine mumps virus infection. On the other hand, several clinical cases of acquired hydrocephalus accompanied with aqueductal stenosis which was caused by mumps virus infection have been reported (Spataro et al, 1976;Thompson, 1979;Rotilio et al, 1985). The Syrian hamster employed in this experiment is born very prematurely at the 16th day of gestation, when the neurons at layer I1 of the cerebral cortex are still being produced in the matrix layer (Shimada and Langman, 1969).…”

Section: Discussionmentioning

confidence: 97%

Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection

Takano

Ohno

Yamano

et al. 1991

Congenital Anomalies

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This study was undertaken to elucidate the pathogenesis of the hydrocephalus and aqueductal stenosis induced by intracerebral mumps virus inoculation in suckling hamsters. Mild ventricular dilatation became apparent after 5 days of inoculation. Focal denuding of the ependymal layer and subsequent aqueductal stenosis were observed by 14 days after inoculation. The virus antigen was detected not only in the ependymal cells and choroid plexus, but also in some neurons in the cerebral cortex, hippocampus, midbrain and cerebellum. In the cerebral aqueduct, the orderly arrangement of the cilialy clusters was destroyed on the 5th day after inoculation. After 10 days, proliferation of GFAP positive cells was noticed around the cerebral aqueduct and subsequently caused aqueductal stenosis. In the advanced state of hydrocephalus, the cerebellum was displaced downward and showed an elongated, atrophic and sleevelike structure similar to the Arnold‐Chiari malformation. It was suggested that the extensive damage of the ependymal cilia may account for early ventricular dilatation, and subsequent aqueductal stenosis with glial proliferation is the main cause of the advanced hydrocephalus. It has not yet been determined whether the mumps virus can pass through the human placenta or not. If it can, however, our results strongly suggest that mumps virus infection in the human fetus will cause congenital hydrocephalus.

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Section: Discussionmentioning

confidence: 97%

Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection

Takano

Ohno

Yamano

et al. 1991

Congenital Anomalies

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“…In viral infections, the mechanism is attributed either to an ependymitis leading to desquamation of ependyma with subsequent mechanical obstruction [5] or to a cross linking between ependymal cells caused by viral particles bridges [6]. At the aqueduct location, where continuous CSF bathing with released viruses takes place, the high accumulation of particles promotes this process [6].…”

Section: Discussionmentioning

confidence: 99%

“…At the aqueduct location, where continuous CSF bathing with released viruses takes place, the high accumulation of particles promotes this process [6]. In addition to that the pathological findings and subsequently the radiological ones do not prove a gliosis compared to the bacterial infections [1].…”

Section: Discussionmentioning

confidence: 99%

Herpes simplex virus Type 1 encephalitis in an adolescent presenting with acute hydrocephalus

Themistocleous

Antoniades

Giakoumettis

et al. 2017

Journal of Surgical Case Reports

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Herpes simplex virus Type 1 (HSV-1) is a human neurotropic virus causing encephalitis, corneal blindness or several peripheral nervous system disorders. Herpes Simplex encephalitis (HSE) is the most devastating clinical syndrome with severe morbidity and mortality. Hydrocephalus associated with viral meningoencephalitis is an extremely rare entity with only few documented cases, predominantly due to HSV-2 infection. HSV-1 infection of central nervous system present in the majority of the cases as encephalitis. We report a rare case of an 11-year-old child suffering from HSV-1 infection of central nervous system causing hydrocephalus without evidence of encephalitis.

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“…Clinical cases with hydrocephalus following mumps virus infection have been reported (Timmons and Johnson, 1970;Bray, 1972;Spataro et al, 1976;Thompson, 1979;Rotilio et al, 1985;Ogata et al, 1992;Lahat et al, 1993). In many of these cases, aqueductal stenosis is suspected of being the main cause of hydrocephalus.…”

Section: Clinical Hydrocephalus Caused By Myxovirusesmentioning

confidence: 99%

Congenital Hydrocephalus: Role of Transplacental Myxovirus Infection

Takano

Uno

Yamano

et al. 1995

Congenital Anomalies

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The definite etiology in most cases of congenital hydrocephalus still remains unknown. Many studies have been reported on the experimental hydrocephalus induced by viral infection other than TORCH (Toxoplasma, Other agents, Rubella virus, Cytomegalovirus and Herpes simplex type 1 and 2 viruses). Above all mumps virus induces a high frequency of hydrocephalus. Several pediatric cases of hydrocephalus after mumps virus infection have been reported. These cases are thought to be caused by ependymitis due to mumps virus infection. Clinical cases of congenital hydrocephalus possibly caused by intrauterine mumps or influenza virus infection are also accumulating. The definitive evidence of a teratogenic potential for mumps and influenza virus, however, has been obscure yet. Our experimental studies demonstrated that mumps and parainfluenza virus type 3 could induce hydrocephalus by destructive ependymal infection in suckling hamsters. However, the transplacental infection of these viruses was rare. These results show that myxoviruses such as mumps and parainfluenza virus have a strong affinity to ependymal cells, and then they cause resultant ependymal destruction. We suggest that when the placenta is impaired so severely that these viruses are able to pass through the placental barrier, maternal infection would cause the hydrocephalus to the infant.

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Aqueductal stenosis following mumps virus infection. Case report

Abstract: A case of aqueductal stenosis following mumps infection is reported, to the authors' knowledge the 12th case in the literature. The pathogenetic events are discussed and the literature reviewed.

Cited by 16 publications

References 10 publications

Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection

Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection

Herpes simplex virus Type 1 encephalitis in an adolescent presenting with acute hydrocephalus

Congenital Hydrocephalus: Role of Transplacental Myxovirus Infection

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