Aquaporins in Glandular Secretion

Calamita, Giuseppe; Delporte, Christine

doi:10.1007/978-981-19-7415-1_16

Cited by 4 publications

(7 citation statements)

References 266 publications

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“…A: adrenalin; Ac: acetylcholine; AC: adenylyl cyclase; Ca ++ : calcium ions; cAMP: cyclic adenosine monophosphate; Cl − : chloride ions; NA: noradrenaline; Na + : sodium ions; PLC: phospholipase C; VIP: vasoactive intestinal peptide. Figure was adapted from [6], reproduced with permission from SNCSC, the Licensed Material is not part of the governing OA license but has been reproduced with permission).…”

Section: Role Of Aqps In Saliva Secretionmentioning

confidence: 99%

“…AQPs are distributed throughout the entire body and fulfill a wide range of physiological functions [1,5]. AQPs are expressed in exocrine and endocrine glands to ensure glandular secretion [6]. This review summarizes the involvement of AQPs in the physiology of glandular secretion ensured by the main exocrine and endocrine glands distributed along the gastrointestinal tract and being involved in food handling.…”

Section: Introductionmentioning

confidence: 99%

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Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Calamita,

Delporte

2023

Cells

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Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner’s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of various fluids involved in food handling. This review summarizes the contribution of AQPs in physiological and pathophysiological stages related to gastrointestinal secretion.

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Section: Role Of Aqps In Saliva Secretionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Calamita,

Delporte

2023

Cells

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“…The increase in [Ca2+] regulates multiple ion channel and transport activities that together generate the osmotic gradient which drives uid secretion across the apical membrane. [6,7] Moreover, calcium play an important role in the maturation of the secretory granules by concentrating secretory proteins through the addition of glycosaminoglycans and the formation of calcium bridges. In addition, the large and highly charged, mucin polymers also must undergo condensation and stabilization by interaction with calcium ions and positively charged organic molecules.…”

Section: Introductionmentioning

confidence: 99%

Importance of calcium on the parotid salivary gland structure (experimental study on rats)

Montaser

Hak

Elba

et al. 2023

Preprint

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Background Calcium makes up 1-2⸓ percent of a person’s body weight, and 99⸓ of it can be found in bones and teeth. The remaining circulates in the blood, muscles, and other tissues. Calcium deficient diet affect general health by causing obesity, fat accumulation, diabetes (insulin resistance), osteoporosis and finally bad oral health due to the non- functioning salivary gland caused by hypocalcemia If calcium deficiency is not treated, it is considered a fatal condition. Calcium is used entirely by the salivary gland to induce its secretory function also it acts as a common modulator mediator for all receptors. Calcium deficiency increases fat cell formation and decreases exocytosis. Aim of this study is to investigate the effect of calcium on general health and on the parotid salivary gland structure in rats. Methods: twenty-four adult male albino rats weighting from 150-200 grams were divided into two groups 12 rat each, group I: control, group II: calcium deficient diet. Body weight, general health observations were measured weekly throughout the experimental period while blood serum level of cholesterol, calcium, insulin, and glucose were all measured at the end of the experiment which lasted for 8 weeks. At the end of the experiment, the rats were euthanized, and the parotid glands were dissected, prepared for light and electron microscopic examination. Results: Group II showed obesity, increase in blood cholesterol, insulin, and glucose level. The ultra-structural and histological examinations showed loss of the normal architecture of acini and duct system as well as the capsule. Conclusion: calcium deficient has a toxic effect on general health and on the parotid salivary gland structure.

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“…Bile is the exocrine secretion of the liver, which is a product of cholesterol metabolism (1)(2)(3). It is stored in the gallbladder and enters into the duodenum via the common bile duct (1,2).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anti-bacterial Effect of Ox-bile Against Some Important Gram-positive and Gram-negative Bacteria

et al. 2023

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Background: Ox-bile has been recommended as a natural remedy with several therapeutic potentials in traditional Persian medicine (TPM). It has had efficacy against inflammation and infection according to traditional medicine. Evidence revealed that bile disrupts bacterial cell membrane and degrades DNA structure, so it has anti-bacterial effects. However, there is no evidence of any approved medication composed of ox-bile in Iran. Objectives: The aim of this study was to evaluate the in vitro anti-bacterial effects of ox-bile. Methods: Ox-bile was obtained under aseptic conditions and sterilized with a 0.22 µm syringe filter, then examined for their sterility status through culture on different media. Following incubation under aerobic cultures for 48 hours and the anaerobic cultures for one week. Two different kinds of antimicrobial susceptibility tests, including well-diffusion method and serial dilution test were employed to characterize the inhibitory effect of ox-bile extraction on Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes. Results: Based on our study, no anti-bacterial effect of ox-bile was observed against selected Gram-positive and Gram-negative bacteria. Conclusions: No in-vitro evidence of inhibitory effect was observed against studied gram-positive and gram-negative bacteria. Though further evaluation of the anti-bacterial effects of different preparations of ox-bile seems is still required.

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Aquaporins in Glandular Secretion

Cited by 4 publications

References 266 publications

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Importance of calcium on the parotid salivary gland structure (experimental study on rats)

In Vitro Anti-bacterial Effect of Ox-bile Against Some Important Gram-positive and Gram-negative Bacteria

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