Aquaporin 5 Interacts with Fluoride and Possibly Protects against Caries

Anjomshoaa, Ida; Briseño-Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernando A.; Mereb, Juan C.; Leite, Aline L.; Barreta, Priscila A. T. M.; Silva, Thelma L.; Dizak, Piper M.; Ruff, Timothy D.; Patır, Aslı; Koruyucu, Mine; Abbasoğlu, Zerrin; Casado, Priscila Ladeira; Brown, Andrew; Zaky, Samer H.; Bayram, Merve; Küchler, Érika Calvano; Cooper, Margaret E.; Liu, Kai; Marazita, Mary L.; Tanboğa, İlknur; Granjeiro, José Mauro; Seymen, Figen; Castilla, Eduardo E.; Orioli, Iêda M.; Sfeir, Charles; Owyang, Hongjiao; Buzalaf, Marília Afonso Rabelo; Vieira, Alexandre R.

doi:10.1371/journal.pone.0143068

Cited by 23 publications

(23 citation statements)

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“…Authors of some studies included in the review observed the SNP phenomenon in genes involved in amelogenesis [Slayton et al, 2005;Deeley et al, 2008;Patir et al, 2008Kang et al, 2011;Olszowski et al, 2012;Shimizu et al, 2012;Tannure et al, 2012a, b;Wang et al, 2012b;Gasse et al, 2013;Chaussain et al, 2014;Duverger et al 2014;Abbasoğlu et al, 2015;Anjomshoaa et al, 2015;Shaffer et al, 2015;Yildiz et al, 2016]. Amelogenesis is a genetically controlled process of enamel development.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Turska‐Szybka²,

2017

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Recent progress in the field of molecular biology and techniques of DNA sequence analysis allowed determining the meaning of hereditary factors of many common human diseases. Studies of genetic mechanisms in the aetiology of caries encompass, primarily, 4 main groups of genes responsible for (1) the development of enamel, (2) formation and composition of saliva, (3) immunological responses, and (4) carbohydrate metabolism. The aim of this study was to present current knowledge about the influence of single nucleotide polymorphism (SNP) genetic variants on the occurrence of dental caries. PubMed/Medline, Embase, and Cochrane Library databases were searched for papers on the influence of genetic factors connected with SNP on the occurrence of dental caries in children, teenagers, and adults. Thirty original papers written in English were included in this review. Study groups ranged from 30 to 13,000 subjects. SNPs were observed in 30 genes. Results of the majority of studies confirm the participation of hereditary factors in the aetiology of caries. Three genes, AMELX, AQP5, and ESRRB, have the most promising evidence based on multiple replications and data, supporting a role of these genes in caries. The review of the literature proves that SNP is linked with the aetiology of dental caries.

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Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Turska‐Szybka²,

2017

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“…Accordingly, several studies in humans have indicated that polymorphisms in genes involved in enamel formation [Patir et al, 2008;Kang et al, 2011;Shimizu et al, 2012;Tannure et al, 2012;Saha et al, 2015], saliva composition [Anjomshoaa et al, 2015;Sengul et al, 2016], and immune response [Bagherian et al, 2008;Azevedo et al, 2010;Valarini et al, 2012;Fine et al, 2013], including DEFB1 [Ozturk et al, 2010;Krasone et al, 2014;Yildiz et al, 2016], play a role in caries susceptibility.…”

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confidence: 99%

Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children

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Antunes²,

Antunes³

et al. 2017

Caries Res

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The antimicrobial peptides human β-defensins (hBDs) are encoded by β-defensin genes (DEFBs) and are possibly involved in caries susceptibility. In this study we aimed (1) to investigate the relationship between salivary hBDs and caries and (2) to evaluate the association of genetic polymorphisms in DEFB1 and microRNA202 (miRNA202) with salivary levels of hBDs and caries experience. Two data sets were available for this study, totalizing 678 Brazilian children. Dental examination and saliva collection were performed in all included children. The salivary level for hDB1, hBD2, and hBD4 was assessed by ELISA sandwich technique in 168 children. The DNA was extracted from saliva, and polymorphisms in DEFB1 and miRNA202 were analyzed by real-time PCR. Statistical analysis was performed to investigate the associations between caries experience, hBD salivary level, genotype, and allele distribution, with an alpha of 0.05. The hBD1 level was significantly higher in caries-free children (p < 0.0001). The miRNA202 was associated with a lower level of salivary hBD1 (p < 0.05). Also, the polymorphic distribution of miRNA202 was associated with caries (p = 0.006). The polymorphisms in DEFB1 were not associated with hBD salivary level and caries experience (p > 0.05). In conclusion, our results indicate that genetic polymorphism in miRNA202 is involved in hBD1 salivary level as well as caries experience in children.

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“…In light of recent results documenting gene-by-fluoride exposure interaction effects on dental caries 26, 27 , we also tested for interaction effects with the two fluoride exposures in the samples of sufficient size for which fluoride exposure data were available (i.e., COHRA1 white adults and COHRA1 white children). These fluoride exposures were dichotomized measures of home water source fluoride (<0.7 ppm vs. ≥0.7 ppm) and tooth brushing frequency (once or more per daily vs. less often than once per day).…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, because previous studies have identified statistical interaction effects on caries between other SCPP genes and fluoride exposures 26, 27 , we also explored whether fluoride may mediate the association of SIBLINGs variants with caries.…”

Section: Introductionmentioning

confidence: 99%

Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries

et al. 2017

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A recent genome-wide association study for dental caries nominated the chromosomal region 4q21 near ABCG2, PKD2 and the SIBLING gene family. In this investigation we followed-up and finemapped this region using a tag-SNP (single nucleotide polymorphism) approach in 13 age-and race-stratified samples from 6 independent studies (N=4,089). Participants were assessed for dental caries via intra-oral examination and 49 tag-SNPs were genotyped capturing much of the variation in the 4q21 locus. Linear models were used to test for genetic association, while adjusting for sex, age, and components of ancestry. SNPs in and near PKD2 showed significant evidence of association in individual samples of black adults (rs17013735, p-value=0.0009) and white adults (rs11938025; p-value=0.0005; rs2725270, p-value=0.003). Meta-analyses across black adult samples recapitulated the association with rs17013735 (p-value=0.003), which occurs at low frequency in non-African populations, possibly explaining the race-specificity of the effect. In addition to race-specific associations, we also observed evidence of gene-by-fluoride exposure interaction effects in white adults for SNP rs2725233 upstream of PKD2 (p=0.002). Our results show evidence of regional replication, though no single variant clearly accounted for the original GWAS signal. Therefore, while we interpret our results as strengthening the hypothesis that chromosome 4q21 may impact dental caries, additional work is needed.

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Aquaporin 5 Interacts with Fluoride and Possibly Protects against Caries

Cited by 23 publications

References 50 publications

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children

Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries

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