Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems

Wang, Yitong; Yan, Miaomiao; Xu, Lu; Zhao, Wenrong; Wang, Xiaolin; Dong, Shuli; Hao, Jingcheng

doi:10.1039/c6tb01224h

Cited by 26 publications

(22 citation statements)

References 31 publications

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“…We previously developed cuboid DNA microgels drug delivery systems with DNA as cross-linking agents which showed excellent biocompatibility and highly selective therapy efficacy for tumor sites. 38 In the present work, DNA not only serves as cross-linking agents for improving the biocompatibility but also takes the role as a valve to control the drugs release. The double-stranded oligonucleotide cross-linked magnetic microgel layers are used to realize magnetic targeting drug delivery by introducing the magnetic ionic liquids as the monomers.…”

Section: ■ Introductionmentioning

confidence: 99%

Near-Infrared-Light-Responsive Magnetic DNA Microgels for Photon- and Magneto-Manipulated Cancer Therapy

Wang

Yan

et al. 2017

ACS Appl. Mater. Interfaces

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Functional DNA molecules have been introduced into polymer-based nanocarrier systems to incorporate chemotherapy drugs for cancer therapy. Here is the first report of dual-responsive microgels composed of a core of Au nanorods and a shell of magnetic ionic liquid and DNA moieties in the cross-linking network simultaneously, as effective drug delivery vectors. TEM images indicated a magnetic polymer shell has an analogous "doughnut" shape which loosely surround the AuNRs core. When irradiated with a near-infrared-light (near-IR) laser, Au nanorods are the motors which convert the light to heat, leading to the release of the encapsulated payloads with high controllability. DNA acts not only as a cross-linker agent, but also as a gatekeeper to regulate the release of drugs. The internalization study and MTT assay confirm that these core-shell DNA microgels are excellent candidates which can enhance the cytotoxicity of cancer cells controlled by near-IR laser and shield the high toxicity of chemotherapeutic agents to improve the killing efficacy of chemotherapeutic agents efficiently in due course.

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Section: ■ Introductionmentioning

confidence: 99%

Near-Infrared-Light-Responsive Magnetic DNA Microgels for Photon- and Magneto-Manipulated Cancer Therapy

Wang

Yan

et al. 2017

ACS Appl. Mater. Interfaces

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“…This is attributed to the fact that testing in less aggressive environments such as deionized water might suppress the microgalvanic corrosion occurring between the bulk grain Mg and T-phase (Mg 7 Zn 3 RE) due to extra resistance. [44][45][46] Also there might be the negligible influence of corrosion products on galvanic corrosion behavior of galvanic samples tested in 0 M NaCl solution which is evident from the EDAX results of the same tabulated in the inset of Figure S1c. The corrosion rate tabulated in Table 1 and from Bode impedance plot tested in 0 M NaCl, Figure 5a, clearly shows that 4th pass galvanic sample exhibited the highest corrosion resistance in 0 M NaCl solution.…”

Section: Potentiodynamic Polarizationmentioning

confidence: 98%

Enhancement of resistance to galvanic corrosion of ZE41 Mg alloy by equal channel angular pressing

Sekar

Sanna

Desai

2019

Materials & Corrosion

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The galvanic corrosion behavior of as‐received and ECAPed ZE41 Mg alloy coupled with Al7075 alloy is investigated using zero resistance ammeter in three different corrosive environments, 0, 0.1, and 1 M NaCl, to mimic the conditions experienced in engineering applications. The mechanism of galvanic corrosion for the ZE41 Mg–Al7075 aluminum alloy is explained. It is observed that a robust surface film containing a composite layer of oxide/hydroxide of magnesium and aluminum is established in deionized water (0 M). However, only a single layer of magnesium oxide/hydroxide is detected in chloride‐containing environments. Equal channel angular pressing (ECAP) improved the resistance to galvanic corrosion by 58% and 54% when compared with the as‐cast counterparts in 0 and 1 M NaCl solution, respectively. In contrast, galvanic corrosion resistance decreased by 26% in 0.1 M NaCl after ECAP while the as‐received samples evinced pits unfavorable to be used in engineering applications. ECAP is a promising method to combat galvanic corrosion encountered by ZE41 magnesium alloy used in automobiles and components of military vehicles.

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Section: Biomedical Applications Of Aoassmentioning

confidence: 99%

Engineered Aptamer‐Organic Amphiphile Self‐Assemblies for Biomedical Applications: Progress and Challenges

Xiong

Liu

Wang

et al. 2021

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Moreover, the characteristic of being nucleic acid molecules provides aptamers with additional distinctive properties: 1) easy modification with a variety of functionalities in a controllable manner; 2) sequence-specific hybridization via Watson−Crick base pairing; 3) conformational changes induced by specific molecular interactions between target and aptamer. All these features make aptamers promising targeting ligands for biomedical applications. Currently, by combining the advantages of nanotechnology and DNA synthesis technology, a wide range of aptamer-functioned nanomaterials have been designed, including 2D nanosheets, gold nanoparticles, liposomes, polymer nanoparticles, DNA nanostructures, which exhibit great potential in bioimaging, biosensing, gene therapy, and targeted drug delivery. [3] Among the aptamer-functionalized nano-systems, aptamer-organic amphiphile self-assemblies (AOASs) have received increasing attention in biomedical field, due to their unique advantages. [4,5] Aptamer-organic amphiphiles (AOAs), prepared by covalently conjugating organic moieties to hydrophilic aptamers, are building blocks to form AOASs via noncovalent driving forces like hydrophobic interactions, hydrogen-bonding, electrostatic interactions, van der Waals forces, and Watson−Crick base pairing. [6,7] The spontaneously shaped AOASs normally have small sizes (10-100 nm) and low critical micelle concentrations (CMCs), which are favorable for tumor accumulation through enhanced permeability and retention (EPR) effect. [8] Generally, AOASs are coreshell nanostructures, where the core and shell are aggregated hydrophobic segment and aptamer corona, respectively. The hydrophobic core can be used to carry multiple water-insoluble compounds, making AOASs serve as versatile carriers for cargo delivery. [9] The aptamer corona renders AOASs with several intriguing merits. First, the high density of aptamers outside endows AOASs with enhanced target binding affinity, called multivalent effect. [10] In addition, the close packing of nucleic acid strands of AOASs can predominantly increase the resistance to nuclease, which is always a big challenge for nucleic acid-based materials. It is speculated that the steric hindrance and a dense anion generated from the close packing of nucleic acid strands could hinder the access of nuclease Currently, nucleic acid aptamers are exploited as robust targeting ligands in the biomedical field, due to their specific molecular recognition, little immunogenicity, low cost, ect. Thanks to the facile chemical modification and high hydrophilicity, aptamers can be site-specifically linked with hydrophobic moieties to prepare aptamer-organic amphiphiles (AOAs), which spontaneously assemble into aptamer-organic amphiphile self-assemblies (AOASs). These polyvalent self-assemblies feature with enhanced target-binding ability, increased resistance to nuclease, and efficient cargo-loading, making them powerful platforms for bioapplications, including targeted drug delivery, cellbased cancer therapy, biosens...

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Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems

Abstract: DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization.

Cited by 26 publications

References 31 publications

Near-Infrared-Light-Responsive Magnetic DNA Microgels for Photon- and Magneto-Manipulated Cancer Therapy

Near-Infrared-Light-Responsive Magnetic DNA Microgels for Photon- and Magneto-Manipulated Cancer Therapy

Enhancement of resistance to galvanic corrosion of ZE41 Mg alloy by equal channel angular pressing

Engineered Aptamer‐Organic Amphiphile Self‐Assemblies for Biomedical Applications: Progress and Challenges

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