Aptamer‐conjugated mesoporous polydopamine for docetaxel targeted delivery and synergistic photothermal therapy of prostate cancer

Dai, Liang; Wei, Dapeng; Zhang, Jidong; Shen, Tianyu; Zhao, Yuming; Liang, Junqiang; Ma, Wang-Teng; Zhang, Limin; Liu, Qingli; Zheng, Yue

doi:10.1111/cpr.13130

Cited by 20 publications

(8 citation statements)

References 60 publications

(77 reference statements)

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“…Similarly, Dai et al. 51 reported that mesoporous PDA could also be modified by AS1411 aptamer and deliver DTX for targeting prostate cancer cells with chemo‐PTT. Furthermore, other substances can be used to coat the surface of PDA based on its strong adhesion property; this would serve to improve cancer therapy with PDT, fluorescence optical imaging, and MRI guidance, such as cationic coating layer, covalent organic frameworks, and metal ions.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 96%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 96%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…This system penetrates BBB via T7 peptide and enters glioma cells with the assistance of T7 peptide and AS1411 aptamer. Dei group [ 263 ] incubated mesoporous polydopamine (MPDA) nanoparticles loaded with DTX, and modified AS1411 aptamer into MPDA, as shown in Fig. 17 A AS1411@MPDA-DTX (AMD) system is constructed by using covalent reaction.…”

Section: The Latest Research On As1411mentioning

confidence: 99%

Progress in cancer drug delivery based on AS1411 oriented nanomaterials

Tong

et al. 2022

J Nanobiotechnol

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Targeted cancer therapy has become one of the most important medical methods because of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and its four-chain structure, this paper reviews the research progress in cancer detection and drug delivery systems by modifying AS1411 aptamers based on graphene, mesoporous silica, silver and gold. The application of AS1411 in cancer treatment and drug delivery and the use of AS1411 as a targeting agent for the detection of cancer markers such as nucleoli were summarized from three aspects of active targeting, passive targeting and targeted nucleic acid apharmers. Although AS1411 has been withdrawn from clinical trials, the research surrounding its structural optimization is still very popular. Further progress has been made in the modification of nanoparticles loaded with TCM extracts by AS1411. Graphical Abstract

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“…Dai et al constructed multifunctional nanoparticles through AS1411 aptamer-conjugated mesoporous polydopamine for targeted and synergistic chemotherapy/photothermal therapy of prostate cancer. 13 Chen et al reported an aptamer-dendrimer functionalized magnetic nano-octahedrons for AS1411 aptamer-targeted, NIR/MR dual-modality imaging guided, and HSP70/HSP90 silencing sensitized magnetochemotherapy. 14 To realize the on-demand release, a series of tumor related stimulus have been employed to design stimuli-triggered drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%