Aptamer-conjugated magnetic nanoparticles for the efficient capture of cancer biomarker proteins

Kiplagat, Ayabei; Martin, Darius Riziki; Onani, Martin O.; Meyer, Mervin

doi:10.1016/j.jmmm.2019.166063

Cited by 18 publications

(6 citation statements)

References 18 publications

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“…Biomolecule detection is based on the identification of tumor markers that are often present in a very small amount in biological samples (Marrugo-Ramírez et al, 2018). The possibility to modify NPs by specific ligands with high affinity for these markers can improve the identification and quantification of desired compounds (Kiplagat et al, 2019).…”

Section: The Role Of Nanoparticles In Cancer Diseasementioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

261

147

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The use of nanoparticles (NP) in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the uptake efficiency significantly limit their use in clinical practice. The physico-chemical properties of NPs including surface composition, superficial charge, size and shape are considered the key factors that affect the biocompatibility and uptake efficiency of these nanoplatforms. Thanks to the possibility of modifying physico-chemical properties of NPs, it is possible to improve their biocompatibility and uptake efficiency through the functionalization of the NP surface. In this review, we summarize some of the most recent studies in which NP surface modification enhances biocompatibility and uptake. Furthermore, the most used techniques used to assess biocompatibility and uptake are also reported.

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Section: The Role Of Nanoparticles In Cancer Diseasementioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

261

147

View full text Add to dashboard Cite

show abstract

“…Magnetic nanoparticles (MNPs) were widely utilized due to their unique properties such as magnetic susceptibility, physical characteristics, stability, biocompatibility, ease of mechanism and many more important outcomes [ 148 , 149 ]. MNPs are used to isolate and purify some molecular compounds, like proteins or nucleic acids, before diagnosis [ 150 , 151 ]. This development was indicated for the detection of various biomarkers of prostate cancer proteins in the urine and bloodstream [ 135 , 152 ].…”

Section: Nanomaterials Towards Diagnosis and Biosensing Of Prostatmentioning

confidence: 99%

Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates

et al. 2020

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The fabrication and development of nanomaterials for the treatment of prostate cancer have gained significant appraisal in recent years. Advancements in synthesis of organic and inorganic nanomaterials with charge, particle size, specified geometry, ligand attachment etc have resulted in greater biocompatibility and active targeting at cancer site. Despite all of the advances made over the years in discovering drugs, methods, and new biomarkers for cancer of the prostate (PCa), PCa remains one of the most troubling cancers among people. Early on, effective diagnosis is an essential part of treating prostate cancer. Prostate-specific antigen (PSA) or serum prostate-specific antigen is the best serum marker widely accessible for diagnosis of PCa. Numerous efforts have been made over the past decade to design new biosensor-based strategies for biomolecules detection and PSA miniaturization biomarkers. The growing nanotechnology is expected to have a significant effect in the immediate future on scientific research and healthcare. Nanotechnology is thus predicted to find a way to solve one of the most and long-standing problem, “early cancer detection”. For early diagnosis of PCa biomarkers, different nanoparticles with different approaches have been used. In this review, we provide a brief description of the latest achievements and advances in the use of nanoparticles for PCa biomarker diagnosis.

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“…Also, there are increasingly more studies reporting on combinations with in vivo fluorescence imaging, sensing and detection. SPIONs have gained a lot of interest in theranostics, which combines diagnostics and treatment by a single intervention, where they show a lot of promise [64,[134][135][136][137][138].…”

Section: Spions Applications: Hyperthermia Imagistics Detectionmentioning

confidence: 99%

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

Suciu¹,

Ionescu²,

Ciorîță³

et al. 2020

Beilstein J. Nanotechnol.

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Superparamagnetic iron oxide nanoparticles (SPIONs) have unique properties with regard to biological and medical applications. SPIONs have been used in clinical settings although their safety of use remains unclear due to the great differences in their structure and in intra- and inter-patient absorption and response. This review addresses potential applications of SPIONs in vitro (formulations), ex vivo (in biological cells and tissues) and in vivo (preclinical animal models), as well as potential biomedical applications in the context of drug targeting, disease treatment and therapeutic efficacy, and safety studies.

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Aptamer-conjugated magnetic nanoparticles for the efficient capture of cancer biomarker proteins

Cited by 18 publications

References 18 publications

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

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