Aptamer-based nanobiosensors

Kim, Yeon Seok; Raston, Nurul Hanun Ahmad; Gu, Man Bock

doi:10.1016/j.bios.2015.06.040

Cited by 354 publications

(74 citation statements)

References 183 publications

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“…LSPR sensors can be constructed using various types of receptors such as aptamers [55,132,133], antibodies [119,[134][135][136][137][138][139][140], MIPs [141][142][143][144], and nucleic acids [100,145,146]. The combination of LSPR with optical fibres to fabricate ultrasensitive sensors for cancer biomarker diagnosis has transformed into an evolving trend.…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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“…However, the fact that more than 80% of the platforms developed never get to meet the market is not yet an open topic of discussion within the field. There is evidence of a significant gap in‐between the lab‐bench technologies and manufacturing processes, where scaling‐up challenges, economic viability, and inherent technology limitations have been ignored at early development stages, preventing a big number of novel technologies from ever been commercialized . This restriction is mainly imposed by the cost‐efficiency, stability of the biomolecules under harsh conditions, and high‐scale reproducibility of the novel biosensing platforms.…”

Section: Introductionmentioning

confidence: 99%

“…According to literature reports, most of the authors describe the incorporation of antibodies or catalytic proteins as bioactive inks for inkjet printing applications; it is well known that immuno‐based strategies are the gold standard for biosensing because of antibodies' high affinity and specificity; unfortunately, these biological molecules have considerable drawbacks mostly related with production costs, stability, shelf‐life and the limitation imposed by the need to interact with the target by immune response . These conditions might affect the biosensors global performance and harm the chances to accomplish future scaling up processes .…”

Section: Introductionmentioning

confidence: 99%

Inkjet Printed Nanopatterned Aptamer‐Based Sensors for Improved Optical Detection of Foodborne Pathogens

Díaz‐Amaya

Zhao

Lin

et al. 2019

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The increasing incidence of infectious outbreaks from contaminated food and water supply continues imposing a global burden for food safety, creating a market demand for on‐site, disposable, easy‐to‐use, and cost‐efficient devices. Despite of the rapid growth of biosensors field and the generation of breakthrough technologies, more than 80% of the platforms developed at lab‐scale never will get to meet the market. This work aims to provide a cost‐efficient, reliable, and repeatable approach for the detection of foodborne pathogens in real samples. For the first time an optimized inkjet printing platform is proposed taking advantage of a carefully controlled nanopatterning of novel carboxyl‐functionalized aptameric ink on a nitrocellulose substrate for the highly efficient detection of E. coli O157:H7 (25 colony forming units (CFU) mL−1 in pure culture and 233 CFU mL−1 in ground beef) demonstrating the ability to control the variation within ±1 SD for at least 75% of the data collected even at very low concentrations. From the best of the knowledge this work reports the lowest limit of detection of the state of the art for paper‐based optical detection of E. coli O157:H7, with enough evidence (p > 0.05) to prove its high specificity at genus, species, strain, and serotype level.

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“…Biocompatible metallic implant material is one of the emerging research areas in medical science . Metallic implants such stainless steel (316 SS), cobalt‐chromium (Co−Cr), Magnesium (Mg) and nickel (Ni) based alloys were used for orthopedic applications.…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin‐Loaded Ceramic/Polymer Composite Coatings on Ti with Improved Antibacterial and Corrosion Resistance Properties for Orthopedic Applications

et al. 2019

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Past few decades witnessed the upcoming of osteomyelitis which is a challenging infectious bone disease. Complications related to this infection is encountered by local drug delivery via orthopedic surgery. In this work, TiO 2 -SiO 2 based bioceramics coatings were fabricated on Ti alloy by anodization method using sulphuric acid and Sodium silicofluoride (SSF) as an electrolyte. Plasma polymerized ethylenediamine (PPEDA) thin film deposited on composites by inductively coupled plasma chemical vapor deposition and followed by ciprofloxacin were used as a model drug by electrodeposition method. The resultant coatings were characterized by FTIR, XRD, FESEM, EDAX and AFM techniques. The mechanical behavior of the composite coatings was evaluated using thickness and hardness tester and electrochemical properties were studied in Ringer's solution. Similarly, CIP@PPEDA/TiO 2 -SiO 2 composite coating on Ti alloy shows good corrosion resistance and better antibacterial efficacy as well as L929 fibroblast cell line, which exhibited a high cell adhesion and high cell viability compared than TiO 2 -SiO 2 and PPEDA/TiO 2 -SiO 2 coatings. All these results suggest that, this newly developed composite coating exhibits superior bioactivity and improved anticorrosion performance on Ti specimen and can be a potential candidate for orthopedic applications.

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Aptamer-based nanobiosensors

Cited by 354 publications

References 183 publications

Recent Progress in Optical Sensors for Biomedical Diagnostics

Recent Progress in Optical Sensors for Biomedical Diagnostics

Inkjet Printed Nanopatterned Aptamer‐Based Sensors for Improved Optical Detection of Foodborne Pathogens

Ciprofloxacin‐Loaded Ceramic/Polymer Composite Coatings on Ti with Improved Antibacterial and Corrosion Resistance Properties for Orthopedic Applications

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