Appropriate Treatment of Invasive Candidiasis in ICU: Timing, Colonization Index, Candida Score &amp; Biomarkers, Towards de-Escalation?

Rosa, Francesco Giuseppe De; Corcione, Silvia; Montrucchio, Giorgia; Brazzi, Luca; Perri, Giovanni Di

doi:10.5152/tjar.2016.0011

Cited by 10 publications

(3 citation statements)

References 35 publications

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“…Physicians should evaluate case-by-case risks and benefits of antifungal treatment after considering treatment timing, risk factors, local microbiological epidemiology, costs, available biomarkers, and diagnostic microbiological assays in their institutions (36,37). Future research should evaluate the effectiveness and applicability of combined strategies using several methods to correctly select patients, who may benefit from timely and adequate untargeted antifungal treatment.…”

Section: Resultsmentioning

confidence: 99%

What Is the Most Recent Evidence on the Prevention and Early Treatment of Invasive Fungal Infections in Nonneutropenic Critically Ill Patients?

Cortegiani

Russotto

Iozzo

et al. 2017

Arch Clin Infect Dis

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Invasive fungal infections (IFIs) are associated with high morbidity and mortality in intensive care units. Candida species are the most important fungal pathogens and among the most frequent causes of infection in critically ill patients. Studies have evaluated the correlation between the onset of antifungal treatment and survival. However, definitive diagnosis of IFI is time-consuming in clinical practice. Antifungal prophylaxis and preemptive or empirical treatments are among therapeutic strategies to prevent or treat early fungal infections in selected patients. Recently, new evidence from randomized controlled trials and systematic reviews has been published. Moreover, new clinical practice guidelines from international communities are available. The aim of this review was to present updated evidence on this topic.

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Section: Resultsmentioning

confidence: 99%

What Is the Most Recent Evidence on the Prevention and Early Treatment of Invasive Fungal Infections in Nonneutropenic Critically Ill Patients?

Cortegiani

Russotto

Iozzo

et al. 2017

Arch Clin Infect Dis

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show abstract

“…Candida is recognized as an important microorganism in healthcare-related infections [ 1 ], which have a rising incidence due to increases in extensive antibiotic administration, invasive treatments, and immunosuppressant use [ 2 ]. Candida infections are associated with a higher risk of mortality than non-fungal infections; the mortality rate can be as high as 90%, depending on associated risk factors [ 3 ]. In the United States, candidemia accounts for 8% of pathogenic bloodstream infection cases (15% in the intensive care unit [ICU]), and Candida is the fourth most commonly identified causative organism in bloodstream infections [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Study onCandidaSpecies in Patients with Cancer in the Intensive Care Unit

Choi

Lee

Park

2017

Osong Public Health Res Perspect

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ObjectivesAlthough cancer survival rates have increased, serious infection complications can arise in cancer patients. Candida can occur in various tissues and has significant effects on the prognosis of patients with cancer. Thus, we conducted an epidemiological study on Candida infections in patients with cancer admitted to the intensive care unit.MethodsA retrospective study was conducted in adult patients with cancer admitted to the intensive care unit between January 1, 2013, and December 31, 2015. Candida infection status and predictive factors for mortality were examined in 634 patients.ResultsThe predictive factors for mortality included the use of steroids, use of a central venous catheter or mechanical ventilator, and identification of Candida in the blood. Patients who stayed in the surgical and intensive care unit for more than 7 days had a lower risk of death than that in those with shorter days.ConclusionThe present study shows that invasive procedures, bloodstream infections, and the use of steroids increase the risk of mortality in Candida-infected patients with cancer. To improve the quality of life and reduce mortality, further studies are needed on the factors affecting the risk of mortality associated with Candida infection.

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“…Furthermore, the predictive values of these scores are not validated for every ICU setting. [ 4 ] Putting these into algorithm will put extra burden on laboratories as well as patients.…”

mentioning

confidence: 99%

A Letter in Response to “Diagnosing Catheter-Associated Urinary Tract Infection in Critically ill Patients: Do the Guidelines Help?”

Behera

2018

Indian Journal of Critical Care Medicine

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Appropriate Treatment of Invasive Candidiasis in ICU: Timing, Colonization Index, Candida Score & Biomarkers, Towards de-Escalation?

Cited by 10 publications

References 35 publications

What Is the Most Recent Evidence on the Prevention and Early Treatment of Invasive Fungal Infections in Nonneutropenic Critically Ill Patients?

What Is the Most Recent Evidence on the Prevention and Early Treatment of Invasive Fungal Infections in Nonneutropenic Critically Ill Patients?

Epidemiological Study onCandidaSpecies in Patients with Cancer in the Intensive Care Unit

A Letter in Response to “Diagnosing Catheter-Associated Urinary Tract Infection in Critically ill Patients: Do the Guidelines Help?”

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