Appropriate timing of blood sampling for blood gas analysis in the ventilated rabbit

Sei, Kiguna; Fujita, Masanori; Okawa, Shinpei; Hirasawa, Takeshi; Kubota, Toshihiro; Sasa, Hidenori; Furuya, Kenichi; Ishihara, Miya

doi:10.1016/j.jss.2016.08.007

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…The low level of partial pressure of oxygen (PO2) and subsequent high level of and partial pressure of carbon dioxide (PCO2) in the blood can occur due to the decline in gases exchange resulting from inflammation and obstruction of the airways which causes the hypoventilation and dyspnea. If the low level of PO2 (hypoxia) is prolonged, it can cause contraction of the blood vessels in the lungs and the pulmonary hypertension [84]. The researchers found that the cell therapy with the MSCs has been able to improve the blood PO2 level through the mediators and inflammation reduction.…”

Section: The Effects Of Msc Therapy On Blood Gases Situationmentioning

confidence: 99%

Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

2020

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The pulmonary diseases are one of the most important causes of death in the world. The successful therapies in the field of lung diseases are very limited and the medical treatments available are ineffective in many of the lung diseases. Many studies have evaluated the new therapies in the acute pulmonary diseases, and the transplantation of mesenchymal stem/stromal cells (MSCs), which is a branch of cell therapy, has a special place among the new medical techniques. The MSCs are present throughout the body and are thought to play a role in tissue regeneration and inflammation control. In the event of injury, the local MSCs traverse the shortest possible distance from the tissue or blood vessels to reach the affected site. But, there are few undifferentiated cells in the tissues. The exogenous MSCs are used to immunity modify or regenerative treatments in preclinical models of acute pulmonary diseases. Several studies have shown the positive effects of MSCs replacement in the acute lung disorders. The effection mechanism of the MSCs include the differentiation ability and the secretion of paracrine agents such as the anti-inflammatory mediators. Many studies suggest that this treatment method is safe and is probably to be widely used in future clinical trials. This review will describe the therapeutic effects of the MSCs in the experimental models of the acute pulmonary diseases for use as a method of treatment in clinical trials in future.

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Section: The Effects Of Msc Therapy On Blood Gases Situationmentioning

confidence: 99%

Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

2020

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“…The results of the analysis of blood gases have an important role in the diagnosis and management of pulmonary capacity, the status of oxygenation and the balance of acid and base. Low levels of oxygen and high levels of carbon dioxide in the blood can occur due to decreasing gas exchange, which results from severe in ammation and obstruction of airway 28 . This condition occurred after the onset of in ammation in the present study.…”

Section: Discussionmentioning

confidence: 99%

Prevention of LPS-induced acute respiratory distress syndrome in sheep by bone marrow-derived mesenchymal stem/stromal cells

et al. 2020

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In this study, 10 male Shall sheep were used in two groups and bone marrow samples were collected and BM-MSCs isolated. Then experimental model of ARDS was induced by intrapulmonary injection of LPS to dose of 400 μg/kg. Twenty-four hours after LPS injection, 5×10 7 cells of BM-MSCs were autologous transferred in the group of treatment and 1ml PBS was infused in the group of control as intrapulmonary. Then, the symptoms of clinical, complete blood count, analysis of arterial blood gases and the concentrations of IL6,IL10,TNF-α,total protein, Ig M and albumin BAL were determined before and at times of 3,6,12,24,48,72, and 168 after transplantation/infusion. The results of the investigations 24 hours post-LPS injection(time 0) indicated the occurrence of acute in ammation which con rmed ARDS model. These changes included increase in RR, HR and RT, decrease in PO2 and SatO2 and increase in PCO2, WBC, neutrophils, macrophages, total protein, IL6, IL10, TNF-α, Ig M and albumin. But the stem/stromal cells transplantation reduced the severity of clinical signs induced by LPS, caused signi cant increase in PO 2 , SatO 2 and IL-10 and signi cant decrease in PCO 2 , the total protein, TNF-α, IL-6, Ig M, albumin, WBCs, neutrophils and macrophages at different times of sampling both in compared with before transplantation(time 0) and in compared with the group of control.While in the control group, in ammation continued until the end of the study. These results showed that BM-MSCs are able to reduce in ammation and have an important role in reconstruction of the damaged lung.

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“…The patient usually breathes the hypoxic gas mixture for 20 min, or until SpO 2 reaches 85%. Although this is shorter than the briefest commercial flight, oxygenation equilibrium is usually reached within this time 134 157. The patient is advised to have in-flight oxygen if PaO 2 falls below 6.6 kPa (<50 mm Hg) or SpO 2 remains <85%1 17 (see page 11).…”

Section: Methodsmentioning

confidence: 99%

BTS Clinical Statement on air travel for passengers with respiratory disease

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Holmes

et al. 2022

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Appropriate timing of blood sampling for blood gas analysis in the ventilated rabbit

Abstract: In ventilated rabbits, arterial PO and SO stabilized in 0.5 min. No venous value stabilized after the RR change. Only the PCO and pH of venous samples may be an alternative to arterial samples under the defined formula.

Cited by 7 publications

References 52 publications

Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

Prevention of LPS-induced acute respiratory distress syndrome in sheep by bone marrow-derived mesenchymal stem/stromal cells

BTS Clinical Statement on air travel for passengers with respiratory disease

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