Approaches to the Dermatopathologic Diagnosis of Figurate Lesions

Neutrophilic figurate erythema of infancy associated with juvenile myelomonocytic leukemia

“…1,2 The lesions may be due to a known cause (rheumatic marginated erythema, neonatal lupus, erythema chronicum migrans) or may be idiopathic 3 and may present with a localized or broad distribution. 2,3 NFEI belongs to those figurate erythemas of unknown etiology.…”

Cold Induced Neutrophilic Figurate Erythema

“…1,2 It is characterized by papular erythematous eruptions with rapid centrifugal enlargement to annular or polycyclic asymptomatic plaques with indurated borders devoid of vesicles, crusts or desquamation.…”

“…2 The patches tend to disappear within 2-4 weeks, but the disease course is chronic. Relapses and recurrences are seen common.…”

“…Relapses and recurrences are seen common. 2 The differential diagnosis of NFE includes Sweet syndrome, plaque sarcoidosis, Jessner's lymphocytic infiltration, annular elastolytic giant cell granuloma, Sjögren's syndrome, neutrophilic type of urticaria, annular variant of subacute cutaneous lupus erythematosus (SCLE), causes of figurate erythema such as erythema chronicum migrans, erythema annulare centrifugum, erythema gyratum repens and its variant familial annular erythema. 1,3,4 Histopathological differential diagnosis of NFE consist some neutrophilic dermatosis such as rheumatoid neutrophilic dermatosis, Behcet's syndrome, urticarial vasculitis , bullous SLE, bullous variant of pyoderma gangrenosum and subcorneal pustular dermatosis.…”

“…1,3,4 Histopathological differential diagnosis of NFE consist some neutrophilic dermatosis such as rheumatoid neutrophilic dermatosis, Behcet's syndrome, urticarial vasculitis , bullous SLE, bullous variant of pyoderma gangrenosum and subcorneal pustular dermatosis. 2,5 Based on clinical, laboratory and histopathological findings, all these diseases could be eliminated. The indurated character and neutrophilic predominancy of the inflammatory infiltrate confirmed the diagnosis of NFE in our patient.…”