Approaches to Chemical Synthesis of Protein-Like Copolymers

Lozinsky, V. I.

doi:10.1007/12_053

Cited by 23 publications

(8 citation statements)

References 55 publications

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“…Experimental work − in this field has been complemented with theoretical predictions. − It has been shown that in dilute solution and at low ionic strength the chains self-assemble and adopt a “pearl-necklace” morphology. Intermolecular aggregation has also been experimentally observed. ,− Copolymers that consist of short sequences of hydrophobic units separated by short sequences of charged hydrophilic units have also been studied as models for proteins. − It was shown that with an appropriate arrangement of the hydrophobic and charged sequences the polymer chains collapse into single-chain globules similar to the coil-to-globule transition of proteins.…”

Section: Introductionmentioning

confidence: 99%

Highlighting the Role of the Random Associating Block in the Self-Assembly of Amphiphilic Block–Random Copolymers

et al. 2015

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pH-sensitive random P(nBA 1−x -stat-AA x ) 100 (MHx) and block−random P(nBA 1−x -stat-AA x ) 100 -b-PAA 100 (DHx) amphiphilic copolymers have been synthesized, where x stands for the molar ratios of pH-sensitive hydrophilic acrylic acid (AA) units statistically distributed with hydrophobic n-butyl acrylate (nBA) ones within the random block. Static and dynamic light scattering revealed that self-assembly of the random associating block (MHx) and block−random (DHx) copolymers is strongly affected by the pH and ionic strength of the solution and also by the amount of AA units within the MHx blocks. Below a characteristic pH, MHx selfassembles into finite size spherical particles that grow in size with decreasing pH until they eventually become insoluble. DHx self-assembles into similar spherical particles, but the hydrophilic PAA 100 corona surrounding the MHx core prevents insolubility at low pH. Self-assembly of DHx at higher pH is fully correlated to that of the neat MHx blocks, indicating that it is possible to control precisely the extent of self-assembly of diblock copolymers by tuning the hydrophobic character of their associating block. Here this was done by controlling the fraction of charged units within the random associating block.

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Section: Introductionmentioning

confidence: 99%

Highlighting the Role of the Random Associating Block in the Self-Assembly of Amphiphilic Block–Random Copolymers

et al. 2015

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“…Despite a very broad distribution of block lengths, the polymers obtained via the conformation-dependent sequence design are able to form stable segregated structures. The stability of globules with a hydrophobic core and a polar shell formed by protein-like copolymers was demonstrated in the computer simulations and in the theory [7,8] and also experimentally [9,10].…”

Section: Balls Packed In a Body-centered Cubic Latticementioning

confidence: 95%

Conformation-dependent sequence design of polymer chains in melts

Govorun¹,

Shupanov²,

Pavlenko³

et al. 2021

J. Phys. A: Math. Theor.

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Conformation-dependent design of polymer sequences can be considered as a tool to control macromolecular self-assembly. We consider the monomer unit sequences created via the modification of polymers in a homogeneous melt in accordance with the spatial positions of the monomer units. The geometrical patterns of lamellae, hexagonally packed cylinders, and balls arranged in a body-centered cubic lattice are considered as typical microphase-separated morphologies of block copolymers. Random trajectories of polymer chains are described by the diffusion-type equations and, in parallel, simulated in the computer modeling. The probability distributions of block length k, which are analogous to the first-passage probabilities, are calculated analytically and determined from the computer simulations. In any domain, the probability distribution can be described by the asymptote ~ k 3/2 at moderate values of k if the spatial size of the block is less than the smallest characteristic size of the domain. For large blocks, the exponential asymptote exp( const 2 as d ka) is valid, d as being the asymptotic domain length (a is the monomer unit size). The number average block lengths and their dispersities change linearly with the block length for lamellae, cylinders, and balls, when the domain is characterized by a single characteristic size. If the domain is described by more than one size, the number average block length can grow nonlinearly with the domain sizes and the length d as can depend on all of them.

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“…The choice of these monomers associated with the fact that on their basis amphiphilic synthetic thermoresponsive polymers are able to be produced, [27] including proteinlike polymers, which are perspective enzyme-like catalysts. [28,29] Later, the offered two-dimensional scale of the amphiphilicity was successfully used by Okhapkin and coauthors for the estimation of the properties of amino acid residues of proteins. [30] These experiments confirmed the universality of the method for the evaluation of the amphiphilicity of various organic substances, and confirmed prospects for the offered approach for the understanding of the relation of the composition of natural proteins with their unique thermosensitive properties.…”

Section: Introductionmentioning

confidence: 99%

Study of amphiphilic properties of amine- and oligo(ethylene glycol)-containing (meth)acrylic monomers

Казанцев

Каморин

Orekhov

et al. 2015

Designed Monomers and Polymers

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The two-dimensional classification was applied to the estimation of hydrophilic-hydrophobic properties of four aminecontaining (meth)acrylic monomers, 2-hydroxyethyl methacrylate, and four oligo(ethylene glycol) methacrylates of various degrees of the ethoxylation. For the monomers, the standard free energy of partition between water and organic phase and standard free energy of adsorption of monomers at the interface were determined in hexane/water systems. Based on the standard free energy of partition and standard free energy of adsorption amphiphilic properties of the monomers were evaluated in terms of the two-dimensional diagram. The monomers were divided into three groups with respect to the position of the monomers in the diagram. These positions are connected with the nature of the substances. The classification allows estimating of monomers partition between interfaces or bulk phases in systems with developed interfaces.

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Approaches to Chemical Synthesis of Protein-Like Copolymers

Cited by 23 publications

References 55 publications

Highlighting the Role of the Random Associating Block in the Self-Assembly of Amphiphilic Block–Random Copolymers

Highlighting the Role of the Random Associating Block in the Self-Assembly of Amphiphilic Block–Random Copolymers

Conformation-dependent sequence design of polymer chains in melts

Study of amphiphilic properties of amine- and oligo(ethylene glycol)-containing (meth)acrylic monomers

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