Approaches in Gene Therapy of Cancer and Cardiovascular Diseases

Roman, Gardlik; Dovinová, Ima; Julie, Y H Chan

doi:10.5772/18280

Cited by 3 publications

(2 citation statements)

References 115 publications

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“…During oxidative stress Nrf2 can be released from connection with Keap1 and is translocated to the nucleus where induces transcription of genes by ARE (Hur et al 2010, Tkachev et al 2011. ARE is present within regulatory areas of several cytoprotective target genes directly involved in the production of antioxidant and detoxification proteins (Reichard et al 2007, Gardlik et al 2011.…”

Section: Effect Of Pparγ On Oxidative Stress and Cell Stress Responsementioning

confidence: 99%

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The Role of PPARγ in Cardiovascular Diseases

Kvandová

Majzúnová²,

Dovinová

2016

Physiol Res

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The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors.PPARγ acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin resistance. PPARγ can modulate several signaling pathways connected with blood pressure regulation. Firstly, it affects the insulin signaling pathway and endothelial dysfunction by modulation of expression and/or phosphorylation of signaling molecules through the PI3K/Akt/eNOS or MAPK/ET-1 pathways.Secondly, it can modulate gene expression of the reninangiotensin system -cascade proteins, which potentially slow down the progression of atherosclerosis and hypertension.Thirdly, it can modulate oxidative stress response either directly through PPAR or indirectly through Nrf2 activation. In this context, activation and functioning of PPARγ is very important in the regulation of several disorders such as diabetes mellitus, hypertension and/or metabolic syndrome.

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Section: Effect Of Pparγ On Oxidative Stress and Cell Stress Responsementioning

confidence: 99%

“…catalase, superoxide dismutase, heme oxigenase-1) and regulation of glutathione production (e.g. glutamatecysteine ligase) (Ishii et al 2002, Gardlik et al 2011, Hur and Gray 2011.…”

Section: Effect Of Pparγ On Oxidative Stress and Cell Stress Responsementioning

confidence: 99%

The Role of PPARγ in Cardiovascular Diseases

Kvandová

Majzúnová²,

Dovinová

2016

Physiol Res

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Brain Stem NOS and ROS in Neural Mechanisms of Hypertension

Chan

2014

Antioxidants & Redox Signaling

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Delivery systems for gene therapy

Mali¹

2013

Indian J Hum Genet

164

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The structure of DNA was unraveled by Watson and Crick in 1953, and two decades later Arber, Nathans and Smith discovered DNA restriction enzymes, which led to the rapid growth in the field of recombinant DNA technology. From expressing cloned genes in bacteria to expressing foreign DNA in transgenic animals, DNA is now slated to be used as a therapeutic agent to replace defective genes in patients suffering from genetic disorders or to kill tumor cells in cancer patients. Gene therapy provides modern medicine with new perspectives that were unthinkable two decades ago. Progress in molecular biology and especially, molecular medicine is now changing the basics of clinical medicine. A variety of viral and non-viral possibilities are available for basic and clinical research. This review summarizes the delivery routes and methods for gene transfer used in gene therapy.

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Approaches in Gene Therapy of Cancer and Cardiovascular Diseases

Cited by 3 publications

References 115 publications

The Role of PPARγ in Cardiovascular Diseases

The Role of PPARγ in Cardiovascular Diseases

Brain Stem NOS and ROS in Neural Mechanisms of Hypertension

Delivery systems for gene therapy

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