The Role of PPARγ in Cardiovascular Diseases

Kvandová, Miroslava; Majzúnová, Miroslava; Dovinová, Ima

doi:10.33549/physiolres.933439

Cited by 77 publications

(63 citation statements)

References 173 publications

(106 reference statements)

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“…PPAR‐α plays a key role in glucose homeostasis and lipid metabolism (Yang, Xiao, & Wang, ), whereas PPAR‐γ is involved in regulating endothelial function, BP, oxidative stress response (Kvandova, Majzunova, & Dovinova, ), mitochondrial dysfunction, and neuro‐inflammation (Agarwal, Yadav, & Chaturvedi, ). Although controversial, PPAR polymorphisms have also been suggested as being associated with coronary heart disease risk (Balakumar, Rose, & Singh, ; Qian et al., ).…”

Section: Bioactivitymentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

393

288

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Flavonoids are plant-derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and the complex pathways involved in bioavailability of flavonoids in the human body are now well understood. In recent years, it has been appreciated that the gut microbiome plays a major role in flavonoid action, but much progress still needs to be made in this area. Since the first publications on the health effects of flavonoids, their action is understood to protect against various stresses, but the mechanism of action has evolved from the now debunked simple direct antioxidant hypothesis into an understanding of the complex effects on molecular targets and enzymes in specific cell types. This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached. Future recommendations based on this historical analysis are (a) to focus on key areas of flavonoid action, (b) to perform human intervention studies focusing on bioavailability and protective effects, and (c) to carry out cellular in vitro experiments using appropriate cells together with the chemical form of the flavonoid found at the site of action; this could be the native form of compounds found in the food for studies on digestion and the intestine, the conjugated metabolites found in the blood after absorption in the small intestine for studies on cells, or the chemical forms found in the blood and tissues after catabolism by the gut microbiota.

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Section: Bioactivitymentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

393

288

View full text Add to dashboard Cite

show abstract

“…Each subtype appears to be protective against cardiovascular disease through their roles in nutrient metabolism, angiogenesis, proliferation, cell migration, inflammation, and oxidative stress. 59,60 Although their roles in vasomotor control are not well defined, PPARs may facilitate normal endothelial function through NO-and NFκB-dependent signaling. 61 For example, aortae of PPARα -/mice exhibit impaired NO signaling and increased oxidative stress.…”

Section: Peroxisome Proliferator-activated Receptorsmentioning

confidence: 99%

Gene expression profiles of ion channels and receptors in mouse resistance arteries: Effects of cell type, vascular bed, and age

et al. 2018

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“…The peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor and nutrition factor in hypertension (Kvandová et al 2016;Tain et al 2016). The activity of PPARγ is influenced by a variety of extracellular ligands -glitazones (rosiglitazone, pioglitazone and troglitazone) and intracellular ligands -prostaglandins, leukotrienes, and α-lipoic acid (Houseknecht et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Age-dependent effect of PPARγ agonist pioglitazone on kidney signaling in borderline hypertensive rats

Grešová

Kvandová²,

Kvasnička³

et al. 2019

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The peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor and nutrition factor which takes part in the cellular signaling by several agonists such as pioglitazone. PPARγ can serve as potential target in treatments of metabolic syndrome diseases and/or hypertension. In the present study we investigated the effects of pioglitazone, a PPARγ agonist, on hypertension development in young and adult borderline hypertensive rats (BHR). In renal signaling we observed connections between PPARγ and Nrf2, antioxidant in adult animals and differences between young and adult BHR in Nrf2-activated detoxificant outputs (NQO1, HO-1) and NO-synthases. Blood pressure in animals had been detected by cuff plethysmography, cell signaling in the kidney was studied by gene expression determination using qPCR, and nitric oxide synthase (NOS) activity was measured by radioactive detection. Pioglitazone treatment in adult BHR caused no detectable changes in antioxidant and detoxificant responses. The main effects were observed in blood pressure improvement, endothelial NOS expression and NOS activities in both young and adult BHR.

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The Role of PPARγ in Cardiovascular Diseases

Cited by 77 publications

References 173 publications

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Gene expression profiles of ion channels and receptors in mouse resistance arteries: Effects of cell type, vascular bed, and age

Age-dependent effect of PPARγ agonist pioglitazone on kidney signaling in borderline hypertensive rats

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