Approaches for breaking the barriers of drug permeation through transdermal drug delivery

Alexander, Amit; Dwivedi, Shubhangi; AJAZUDDIN, .; Giri, Tapan Kumar; Saraf, Swarnlata; Saraf, Shailendra; Tripathi, Dulal Krishna

doi:10.1016/j.jconrel.2012.09.017

Cited by 428 publications

(245 citation statements)

References 154 publications

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“…4,5 Polymers suitable for use in skin drug delivery systems need to be stable, nonreactive with the drug, inexpensive, and easily manufactured. 6 The zein storage proteins are frequently found in maize endosperm, where they are deposited as protein bodies within the rough endoplasmic reticulum. 7,8 Zeins are renewable, biodegradable, biocompatible, and nontoxic.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Marini¹,

Martelli²,

Zornio³

et al. 2014

Química Nova

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Biodegradable nanoparticles (NPs) have received considerable attention because of their possible use in the development of strategies for the topical delivery of oils and therapeutic drugs, particularly when drug penetration in dermis is desired. Zein is a prolamine and is a promising material for the design of drug delivery systems. In this study, NPs were prepared with zein and were used to encapsulate and release terpinen-4-ol, which is a therapeutic agent for the treatment of melanoma. The results show that the zein NPs are promising nanostructured systems for the prolonged delivery of T4OL with potential applications in anti-melanoma therapy.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Marini¹,

Martelli²,

Zornio³

et al. 2014

Química Nova

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“…The skin surface area in an adult is approximately 2 m 2 , and the skin weight is about 15% of the total body weight [10]. Skin is an essential and vital organ and is a marker of health.…”

Section: Skinmentioning

confidence: 99%

Penetration Test of Caffeine in Ethosome and Desmosome Gel Using an in Vitro Method

2017

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Objectives: Caffeine has many functions including its use in the field of cosmetics. Nonetheless, the percutaneous absorption of caffeine is very low (9%), and the penetration of a substance such as caffeine in the skin is not desirable. Ethosomes and desmosomes are lipid vesicles created by the modification of liposomes containing phospholipids and ethanol or dimethyl sulfoxide (DMSO) as the penetration enhancer. The purpose of this study was to compare the effectiveness of ethosomes and desmosomes as vesicles in increasing the penetration of caffeine.Methods: Ethosomes and desmosomes were prepared using phosphatidylcholine, ethanol/DMSO, and caffeine. Phosphatidylcholine was used in the form of phospholipon 90 g that was obtained from soybeans. Observations were done including the characteristic of ethosomes and desmosomes, organoleptic observation, homogeneity observation, and in vitro penetration test using Franz diffusion cell method. Results Conclusions:It can be concluded that ethosome is more effective than desmosome in increasing the penetration of caffeine.

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“…In the case of lipophilic PSAs, incorporation of the hydrophilic drug/polymer binary mixture within the PSA, results in the formation of a microreservoir system. Microreservoir-type transdermal drug delivery systems (MTDDS) are dispersions of microscopic drug reservoirs (spheres) 7,8 within the polymer matrix 9 .…”

Section: Abbreviations and Symbolsmentioning

confidence: 99%

Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier

Chenevas-Paule

Wolff

Ashton

et al. 2017

Journal of Pharmaceutical Sciences

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Approaches for breaking the barriers of drug permeation through transdermal drug delivery

Cited by 428 publications

References 154 publications

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Biodegradable Nanoparticles Obtained From Zein as a Drug Delivery System for Terpinen-4-Ol

Penetration Test of Caffeine in Ethosome and Desmosome Gel Using an in Vitro Method

Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier

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