Approach to Role of Capsaicin - Sensitive Afferent Nerves in the Development and Healing in Patients with Chronic Gastritis

Mózsik, Gyula; Szabó, Imre; Dömötör, A.

doi:10.5772/24603

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…(Mózsik et al 2011). , CGRP, SP (in percent, means SEM) Chamges in the expression of capsaicin receptor (TRPV1), calcitonin gene-ralated peptide (CGRP) and substabtance P (SP) in the human gastric mucosa of healthy voluntaries(histologically intact) (A), H. pylori positive (B), H. pylori negative (C) and H. pylori positive before (D) and after eradication (pantoprazole 40, amoxicillin 1000 and clarithromycin 500 mg, all two times per day, for seven days) (n=number of patients) (Mózsik et al 2012).…”

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confidence: 99%

Capsaicin-Sensitive Afferentation Represents a New Mucosal Defensive Neural Pathway System in the Gastric Mucosa in Patients with Chronic Gastritis

Czimmer¹,

Szabó²,

Szolcsányi³

et al. 2013

Current Topics in Gastritis - 2012

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mentioning

confidence: 99%

Capsaicin-Sensitive Afferentation Represents a New Mucosal Defensive Neural Pathway System in the Gastric Mucosa in Patients with Chronic Gastritis

Czimmer¹,

Szabó²,

Szolcsányi³

et al. 2013

Current Topics in Gastritis - 2012

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Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Mózsik

2014

Capsaicin as a Therapeutic Molecule

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Background: Capsaicin is a specific compound acting on capsaicin-sensitive afferent nerves. Aim: Capsaicin was used to study the different events of human gastrointestinal physiology, pathology, and clinical pharmacology, and possible therapeutic approaches to enhance gastrointestinal mucosal defense in healthy human subjects and in patients with various different gastrointestinal disorders as well as its use with nonsteroidal anti-inflammatory drugs (NSAIDs) in healthy subjects and in patients. Materials and Methods: The observations were carried out in 198 healthy human subjects and in 178 patients with different gastrointestinal (GI) diseases (gastritis, erosions, ulcer, polyps, cancer, inflammatory bowel diseases, colorectal polyps, cancers), and in 69 patients with chronic (Helicobacter pylori positive and negative) gastritis (before and after eradication treatment). The gastric secretory responses and their chemical composition, gastric emptying, sugar loading test, gastric transmucosal potential difference (GTPD) with application of capsaicin alone, after ethanol alone and with capsaicin, indomethacin-induced gastric mucosal microbleeding without and with capsaicin were studied. The immunohistochemical examinations of the capsaicin receptor (TRVP1), calcitonin gene-related peptide (CGRP), and substance P (SP) were carried out in gastrointestinal tract, and especially in patients with chronic gastritis (with and without Helicobacter infection, before and after classical eradication treatment). Classical molecular pharmacological methods were applied to study the drugs inhibiting the gastric basal acid output. Results: Capsaicin decreased the gastric basal output, enhanced the "non-parietal" (buffering) component of gastric secretory responses, and gastric emptying, and the release of glucagon. Capsaicin

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Orally Given Capsaicinoids do not Modify the Absorption, Metabolism, and Excretion of Aspirin and its Platelet Aggregation in Human Male Healthy Subjects (Human Clinical Pharmacological Phase. I. Examinations)

Mózsik¹,

Past²,

Habon³

et al. 2014

J. Adv. Clin. Pharmacol

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Approach to Role of Capsaicin - Sensitive Afferent Nerves in the Development and Healing in Patients with Chronic Gastritis

Cited by 3 publications

References 35 publications

Capsaicin-Sensitive Afferentation Represents a New Mucosal Defensive Neural Pathway System in the Gastric Mucosa in Patients with Chronic Gastritis

Capsaicin-Sensitive Afferentation Represents a New Mucosal Defensive Neural Pathway System in the Gastric Mucosa in Patients with Chronic Gastritis

Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Orally Given Capsaicinoids do not Modify the Absorption, Metabolism, and Excretion of Aspirin and its Platelet Aggregation in Human Male Healthy Subjects (Human Clinical Pharmacological Phase. I. Examinations)

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