Capsaicin-Sensitive Afferentation Represents a New Mucosal Defensive Neural Pathway System in the Gastric Mucosa in Patients with Chronic Gastritis

Czimmer, József; Szabó, Imre; Szolcsányi, Janós; Mózsik, Gyula

doi:10.5772/52883

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The last step of our observations indicated that capsaicin-sensitive afferentation did not differ before and 6 weeks after successful eradication treatment in patients with chronic H. pylori positive gastritis (meanwhile the control biopsy was normal in 22-78 % indicated a moderate improvement of the histological picture of gastritis) (Lakner et al 2011;Mózsik et al 2011aMózsik et al , b, 2014Czimmer et al 2013). After careful analysis of these results, it can be stated that the capsaicin-sensitive afferentation represents as an essential pathway in the healing of chronic gastritis (probably without and with Helicobacter pylori infection).…”

Section: Capsaicin-sensitive Afferentation In Patients Withmentioning

confidence: 85%

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Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Mózsik

2014

Capsaicin as a Therapeutic Molecule

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Background: Capsaicin is a specific compound acting on capsaicin-sensitive afferent nerves. Aim: Capsaicin was used to study the different events of human gastrointestinal physiology, pathology, and clinical pharmacology, and possible therapeutic approaches to enhance gastrointestinal mucosal defense in healthy human subjects and in patients with various different gastrointestinal disorders as well as its use with nonsteroidal anti-inflammatory drugs (NSAIDs) in healthy subjects and in patients. Materials and Methods: The observations were carried out in 198 healthy human subjects and in 178 patients with different gastrointestinal (GI) diseases (gastritis, erosions, ulcer, polyps, cancer, inflammatory bowel diseases, colorectal polyps, cancers), and in 69 patients with chronic (Helicobacter pylori positive and negative) gastritis (before and after eradication treatment). The gastric secretory responses and their chemical composition, gastric emptying, sugar loading test, gastric transmucosal potential difference (GTPD) with application of capsaicin alone, after ethanol alone and with capsaicin, indomethacin-induced gastric mucosal microbleeding without and with capsaicin were studied. The immunohistochemical examinations of the capsaicin receptor (TRVP1), calcitonin gene-related peptide (CGRP), and substance P (SP) were carried out in gastrointestinal tract, and especially in patients with chronic gastritis (with and without Helicobacter infection, before and after classical eradication treatment). Classical molecular pharmacological methods were applied to study the drugs inhibiting the gastric basal acid output. Results: Capsaicin decreased the gastric basal output, enhanced the "non-parietal" (buffering) component of gastric secretory responses, and gastric emptying, and the release of glucagon. Capsaicin

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Section: Capsaicin-sensitive Afferentation In Patients Withmentioning

confidence: 85%

“…9.9), meanwhile on significant expressions obtained in SP of gastric mucosa in these groups) (Dömötör et al 2005;Lakner et al 2011;Mózsik et al 2011Mózsik et al , 2014Czimmer et al 2013;Vincze et al 2004) (Figs. 9.9, 9.13, 9.14 and Table 9.4).…”

Section: Capsaicin-sensitive Afferentation In H Pylori Positive Chromentioning

confidence: 99%

Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Mózsik

2014

Capsaicin as a Therapeutic Molecule

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Capsaicin-Sensitive Afferent Nerves and the Human Gastrointestinal Tract

Mózsik¹,

Dömötör²,

Czimmer³

et al. 2014

Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: From Bench to Bedside

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Capsaicin-Sensitive Afferentation Represents a New Mucosal Defensive Neural Pathway System in the Gastric Mucosa in Patients with Chronic Gastritis

Cited by 2 publications

References 41 publications

Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Capsaicin-Sensitive Afferent Nerves and the Human Gastrointestinal Tract

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