Approach to infantile hemangiomas

Abraham, Anil; Job, Anupa Mary; Roga, Gillian

doi:10.4103/0019-5154.177755

Cited by 8 publications

(13 citation statements)

References 21 publications

(32 reference statements)

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“…5,21 Several theories have been proposed, of which Folkman Klagsbrun placental theory, endothelial progenitor cell theory, hypoxia theory, and angiogenesis theory are the most accepted. 3 GLUT-1, Lewis Yantigen, FcyRII, merosin, and VEGF were involved in the pathophysiology of infantile hemangioma. 22 In the present study, with peptidomics analysis on infantile hemangioma tissue, a total of 192 differentially expressed peptides derived from 34 precursor proteins were identified compared with matched normal skin.…”

Section: Discussionmentioning

confidence: 98%

“…Molecular mechanisms of hemangioma formation have been widely reported . Several theories have been proposed, of which Folkman Klagsbrun placental theory, endothelial progenitor cell theory, hypoxia theory, and angiogenesis theory are the most accepted . GLUT‐1, Lewis Yantigen, FcyRII, merosin, and VEGF were involved in the pathophysiology of infantile hemangioma .…”

Section: Discussionmentioning

confidence: 99%

“…2 At present, although surgical modalities and non-surgical methods including lasers, radiotherapy, systemic or intralesional corticosteroids, and beta-blockers particularly propranolol have been used to cure infantile hemangiomas, ambiguity still prevails. 3 Therefore, further understanding the pathogenesis of infantile hemangiomas and exploring effective therapeutic approach are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

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Endogenous peptides profiles of human infantile hemangioma tissue and their clinical significance for treatment

Chen

et al. 2018

J of Cellular Biochemistry

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Endogenous peptides play crucial roles in various biological processes. Their effects on the pathogenesis of human infantile hemangioma remains poorly understood. In this study, we construct a comparative peptidomic profiling between human infantile hemangioma tissue and matched normal skin using liquid chromatography-tandem mass spectrometry. A total of 192 peptides were significantly differentially expressed in human infantile hemangioma tissue, with 182 upregulated, and 10 downregulated peptides between infantile hemangioma tissue and matched normal skin. Performing bioinformatics analysis (Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis), we found that precursor proteins of these differentially expressed peptides correlate with metabolic process, biological regulation, binding, catalytic activity, and pathways in cancer occurring during pathological changes of infantile hemangioma. Furthermore, 89 differentially expressed peptides shared homology with antimicrobial peptides and 13 matched known immunomodulatory peptides based on prediction database. In conclusion, our results reveal significantly altered expression profiles of peptides in human infantile hemangioma tissue. These peptides may participate in the etiology of infantile hemangioma and provide beneficial scheme for clinical treatments.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endogenous peptides profiles of human infantile hemangioma tissue and their clinical significance for treatment

Chen

et al. 2018

J of Cellular Biochemistry

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“…[2] The pathogenesis of hemangioma has been widely studied, and several theories have been proposed, among which endothelial progenitor cell theory, Folkman Klagsbrun placental theory, angiogenesis theory, and hypoxia theory are the most accepted. [23] To date, circRNA profiles by microarray analysis in the IHs have been reported, [11] and 234 up- and 374 downregulated circRNAs were identified in IH by microarray. [11] In this study, based on the RNA-Seq technique, we found that 249 circRNAs are dysregulated in IH including 124 upregulated and 125 downregulated circRNAs.…”

Section: Discussionmentioning

confidence: 99%

Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq

Li²,

Chen³

et al. 2018

Medicine

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We found that of the 9811 identified circRNAs, 249 candidates were differentially expressed, including 124 upregulated and 125 downregulated circRNAs in the IH group compared with the matched normal skin control group. A set of differentially expressed circRNAs (in particular, hsa_circRNA001885 and hsa_circRNA006612 expression) were confirmed using qRT-PCR. Gene ontology and pathway analysis revealed that compared to matched normal skin tissues, many processes that were over-represented in IH group were related to the binding, protein binding, gap junction, and focal adhesion. Specific circRNAs were associated with several micro-RNAs (miRNAs) predicted using miRanda. Altogether, our findings highlight the potential importance of circRNAs in the biology of IH and its response to treatment.

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“…On MRI, typical features in the proliferating phase include dilated feeding vessels, variable intensity T1, hyperintense T2, and flow voids around and within the mass. In the involuted phase, decrease in the vessel size is seen [20].…”

Section: Hemangiomasmentioning

confidence: 99%

In-utero Diagnosis of Double Encephalocele - Imaging Features and Review of Literature

Shah¹,

Lee²,

Jeph³

2021

Radiology Case

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Encephalocele is protrusion of brain parenchyma through a defect in the cranium. It is classified into various types based on the defect location: sincipital (fronto-ethmoidal), basal (trans-sphenoidal, spheno-ethmoidal, trans-ethmoidal, and spheno-orbital), occipital and parietal. Double encephaloceles are very rare with only a handful of cases reported in the literature and most of these cases involved either occipital or sub-occipital region. All, except one, cases of double encephaloceles were diagnosed postnatally. We present a case of double encephalocele with parietal and occipital components diagnosed in utero. To the best of our knowledge, this is the first case of double encephalocele involving the parietal and occipital skull bones diagnosed in-utero.

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Approach to infantile hemangiomas

Abstract: Infantile hemangiomas are a group of vascular tumors and are considered to be one of the most common tumors in infancy. Ambiguity still prevails over its origin, etiopathogenesis, and optimal management.

Cited by 8 publications

References 21 publications

Endogenous peptides profiles of human infantile hemangioma tissue and their clinical significance for treatment

Endogenous peptides profiles of human infantile hemangioma tissue and their clinical significance for treatment

Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq

In-utero Diagnosis of Double Encephalocele - Imaging Features and Review of Literature

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