Appraisal of in vitro and in vivo antioxidant activity potential of cornelian cherry leaves

Celep, Engin; Aydın, Ahmet; Kırmızıbekmez, Hasan; Yeşilada, Erdem

doi:10.1016/j.fct.2013.09.001

Cited by 60 publications

(47 citation statements)

References 30 publications

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“…Many studies examining the in vitro antioxidant activity of extracts have also evaluated extract antioxidant activity in oxidative stress-induced animal models (32–34). We show here that hyperlipidemia induced by a fat and cholesterol-enriched diet increases blood and liver lipid levels in rats, thereby leading to oxidative stress that can be partly prevented by the antioxidant activities of spinach.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats

Ko¹,

Park²,

Kim³

et al. 2014

JFN

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Increased consumption of fresh vegetables that are high in polyphenols has been associated with a reduced risk of oxidative stress-induced disease. The present study aimed to evaluate the antioxidant effects of spinach in vitro and in vivo in hyperlipidemic rats. For measurement of in vitro antioxidant activity, spinach was subjected to hot water extraction (WE) or ethanol extraction (EE) and examined for total polyphenol content (TPC), oxygen radical absorbance capacity (ORAC), cellular antioxidant activity (CAA), and antigenotoxic activity. The in vivo antioxidant activity of spinach was assessed using blood and liver lipid profiles and antioxidant status in rats fed a high fat-cholesterol diet (HFCD) for 6 weeks. The TPC of WE and EE were shown as 1.5±0.0 and 0.5±0.0 mg GAE/g, respectively. Increasing the concentration of the extracts resulted in increased ORAC value, CAA, and antigenotoxic activity for all extracts tested. HFCD-fed rats displayed hyperlipidemia and increased oxidative stress, as indicated by a significant rise in blood and liver lipid profiles, an increase in plasma conjugated diene concentration, an increase in liver thiobarbituric acid reactive substances (TBARS) level, and a significant decrease in manganese superoxide dismutase (Mn-SOD) activity compared with rats fed normal diet. However, administration of 5% spinach showed a beneficial effect in HFCD rats, as indicated by decreased liver TBARS level and DNA damage in leukocyte and increased plasma conjugated dienes and Mn-SOD activity. Thus, the antioxidant activity of spinach may be an effective way to ameliorate high fat and cholesterol diet-induced oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats

Ko¹,

Park²,

Kim³

et al. 2014

JFN

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“…(6,7). Bitkilerin antioksidan aktivite kapasiteleri, uygulanan ekstraksiyon yöntemine ve analitik yönteme göre değişkenlik göstermektedir (8,22). Demleme sıcaklığının çayın antioksidan aktivitesi üzerine etkisinin incelendiği bir çalışmada, 70°, 80°, 90° ve 100°C ile karşılaştırıldığında en yüksek antioksidan aktivitenin 80°C'de gözlendiği bildirilmiştir (23).…”

Section: Discussionunclassified

“…Örneklerin total antioksidan kapasitelerinin TOAK değerlerinin belirlenmesi için fosfomolibden metodu kullanılmıştır (8). Deney antioksidan bileşiklerin Mo(VI)'yı Mo(V)'e indirgemesine ve sonuç olarak asidik ortamda yeşil fosfomolibdat kompleksine dönüşmesi esasına dayanmaktadır.…”

Section: Total Antioksidan Kapasite Analiziunclassified

Bitki Çaylarına Bal İlavesinin Total Antioksidan Kapasitesine Etkisi

Özdatlı¹

2014

mpj

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“…Due to ceaselessly evolving means of resistance by pathogenic bacteria to currently available antibiotics, the discovery of new and potent antibacterial drugs is the best way to overcome bacterial resistance and develop effective therapies [2]. Oxidative stress is attributed to the etiology of several diseases such as diabetes, cancer, and cardiovascular disorders [3]. In today's world, the more concerning problem is reactive oxygen species (ROS) and free radical-mediated oxidative damage of cell membranes, DNA, and proteins associated with ageing, cancer, and atherosclerosis [4,5].…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and biological evaluation of thiourea and guanidine derivatives of pyrimidine-6-carboxylate

et al. 2014

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Two new series of methyl 7-methyl-5-(substituted-phenyl)-3,5-dihydro-2H-substituted [3,2-a]pyrimidine-6-carboxylate derivatives of thiourea and guanidine were synthesized. These compounds were characterized and evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and antifungal Aspergillus niger and Candida albicans and free radical scavenging activity using DPPH reagent method. Compound 7f was found to be the most active antibacterial and antifungal agent comparable to the standard drugs ciprofloxacin and fluconazole. Further, the compounds 5e, 7g, and 7h were also found to have significant antimicrobial activity. Compound 5a was found to be the most active antioxidant among all the targeted compounds, while compounds 5b, 5g, 7b, and 7f also had significant antioxidant activity compared to standard ascorbic acid.

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Appraisal of in vitro and in vivo antioxidant activity potential of cornelian cherry leaves

Cited by 60 publications

References 30 publications

Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats

Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats

Bitki Çaylarına Bal İlavesinin Total Antioksidan Kapasitesine Etkisi

Design, synthesis, and biological evaluation of thiourea and guanidine derivatives of pyrimidine-6-carboxylate

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