Applying current normative data to prognosis in heart failure: The Fitness Registry and the Importance of Exercise National Database (FRIEND)

Moneghetti, Kegan; Hock, Julia; Kaminsky, Leonard A.; Arena, Ross; Haddad, François; Wheeler, Matthew T.; Froelicher, Victor F.; Ashley, Euan A.; Myers, Jonathan; Christle, Jeffrey W.

doi:10.1016/j.ijcard.2018.02.102

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…In the subgroup of participants who had enhanced cardiovascular imaging studies, we discovered two major health findings: one cardiac finding associated with a pathogenic mutation in the RPM20 gene, and one non-cardiac finding (Table S2). Fitness assessment using percent predicted oxygen consumption (maximal oxygen consumption relative to a healthy person of the same age and weight) identified three participants with values below 70% suggestive of a reduction in exercise capacity which has been associated with poorer health outcomes 37 (Extended Data Fig. 7a).…”

Section: Resultsmentioning

confidence: 99%

A longitudinal big data approach for precision health

Rose

Contrepois

Moneghetti

et al. 2019

Nat Med

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354

271

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Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable monitoring enable deep molecular and physiological profiling and may provide important tools for precision health. We explored the ability of deep longitudinal profiling to make health-related discoveries, identify clinically relevant molecular pathways, and impact behavior in a prospective longitudinal cohort ( n = 109) enriched for risk of type 2 diabetes mellitus (DM). The cohort underwent integrative Personalized Omics Profiling (iPOP) from samples collected quarterly for up to 8 years (median 2.8 years) using clinical measures and emerging technologies including genome, immunome, transcriptome, proteome, metabolome, microbiome, and wearable monitoring. We discovered over 67 clinically actionable health discoveries and identified multiple molecular pathways associated with metabolic, cardiovascular and oncologic pathophysiology. We developed prediction models for insulin resistance using omics measurements illustrating their potential to replace burdensome tests. Finally, study participation lead the majority of participants to implement diet and exercise changes. Altogether, we conclude that deep longitudinal profiling can lead to actionable health discoveries and provide relevant information for precision health.

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Section: Resultsmentioning

confidence: 99%

A longitudinal big data approach for precision health

Rose

Contrepois

Moneghetti

et al. 2019

Nat Med

Self Cite

354

271

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“…One-RM strength is the largest amount of weight for a particular workout that a person can lift only once [35]. Several experiments have used either a generalized prediction equation [36] or prediction equations for individual exercises to produce regression equations to forecast 1-RM power [37]. It should be remembered that most of the simplified calculations are based on the exercise of the bench press [38], as it is one of the exercises done more often (Table 2).…”

Section: Inclusivenessmentioning

confidence: 99%

Dealing with Delayed Onset Muscle Soreness (DOMS): Foam Roller or Mechanical Manipulation of Body Tissue

Nazarudin¹,

Abdullah²,

Razak³

et al. 2021

saj

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This research focuses on determining the efficacy of sports massage (SM) and foam rolling (FR) to decrease Delayed Onset Muscle Soreness (DOMS) among users of recreational gyms. The goal of this study is to fit the physiotherapist's more efficient technique or techniques to scale back DOMS. SM and FR are two factors that help to illustrate the efficacy of DOMS scale back. Both therapies, SM and FR party, were handled with the selected samples for this analysis. Repeated measure ANOVA was used for testing results on the impact of SM on the range of motion (ROM). Results showed the effect of SM on pain meter supported on three occasions, and the effect of froth rolling on the pain meter on three times. Results suggest that there are not substantially different effects between therapies for all elbow flexion ranges of motion. Both therapies are often used to minimize DOMS due to growth over a 3-fold duration. The researcher has dressed up a couple of the guidelines and ideas required for future studies to be used. Future research should refer to the feminine community to boost the performance.

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“…(Am J Cardiol 2020;125:76−81) Impaired cardiorespiratory fitness (CRF) is central to the heart failure (HF) syndrome, and portends a poor quality of life and an increased mortality in HF across a wide range of left ventricular ejection fraction (LVEF). 1 However, LVEF has been shown to poorly correlate with CRF in HF and additional cardiac determinants of CRF, such as cardiac output and diastolic reserve may contribute to the reduced exercise capacity. 2−4 Further, CRF may be constrained by noncardiac or systemic factors that include aging, systemic inflammation, skeletal muscle dysfunction, obesity, and pulmonary disease.…”

mentioning

confidence: 99%