Applications of Zero-Valent Silicon Nanostructures in Biomedicine

Kafshgari, Morteza Hasanzadeh; Voelcker, Nicolas H.; Harding, Frances J.

doi:10.2217/nnm.15.91

Cited by 29 publications

(36 citation statements)

References 156 publications

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“…Even suffering from lower biocompatibility compared to certain kinds of nanomaterials (e.g., porous silicon, lipid, and poly(lactic‐ co ‐glycolic acid) NPs), well‐established functionalization techniques have been developed for plasmonic NPs to achieve long‐term dispersibility, biocompatibility, and chemical stability. [ 122 ] A broad range of plasmonic nanostructures has been designed for specific absorption and scattering spectra as well as “hot‐spots” for field enhancement. The large adsorption cross section of plasmonic NPs and their contrast between surrounding tissue enabled the localized photothermal effect, precise hyperthermia treatment, photoacoustic imaging and optoporation phenomena, while minimizing irreversible damages to healthy cells and tissues.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Wang

Kafshgari

Meunier

2020

Adv Funct Materials

366

234

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Noble metal nanoparticles due to their unique optical properties arising from their interactions with an incident light have been intensively employed in a broad range of applications. This review comprehensively describes fundamentals behind plasmonics, used to develop applications in the fields of biomedical, energy, and information technologies. Basic concepts (electromagnetic interaction and permittivity of metals) are discussed through Mie theory presented as the main model for interpreting phenomena of optical absorption and scattering. The effects of near‐field enhancement, shape, composition, and surrounding medium of nanoparticles on optical properties are described in detail. The review explores and identifies the potential of plasmonic nanoparticles based on their optical properties (e.g., light absorption, scattering, and field enhancement) for developing different applications (biomedical, energy and information technologies). Due to a significant impact of plasmonic nanoparticles on medicine and healthcare products and technologies, the review initially focuses on biomedical applications extensively benefited from optical features of these nanoparticles. Advantages of the optical properties outstandingly implemented are also briefly discussed in other applications, including energy and information technologies. This review concisely summarizes the explored areas based on plasmonic properties, compares advantages of plasmonic nanoparticles over other types of nanomaterials and highlights challenges.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Wang

Kafshgari

Meunier

2020

Adv Funct Materials

366

234

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“…On the other hand, polymeric surface modifications can reduce or diminish hazard risks caused by the administration of TiO 2 nanomaterials [134][135][136][137]. The surface modifications may suppress the reactivity of crystals and minimize cellular and subcellular obstructive interactions [44,125,138]. However, polymeric surface modifications must be conscientiously optimized, because a hydrophilic and positively charged polymeric layer on the surface of nanomaterials may cause severe obstructive interactions within the subcellular compartments and consequently produce greater ROS and cytotoxicity [139].…”

Section: In Vitro Cytotoxicity Assessmentsmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

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HIGHLIGHTS • Multifunctional TiO 2 nanostructures hold promise for advancing a wide range of biomedical applications due to a feasible integration of distinct theranostic features. • Fabrication and post-fabrication strategies implemented to generate multifunctional TiO 2 nanostructures for a broad range of biomedical applications are briefly outlined. The opportunities and challenges of TiO 2 nanomaterials are highlighted in order to open the possibility of clinical translation. ABSTRACT Titanium dioxide (TiO 2 ) nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications. TiO 2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement, thermal conversion, specific surface area, and surface activity. This review highlights certain important aspects of fabrication strategies, which are employed to generate multifunctional TiO 2 nanostructures, while outlining post-fabrication techniques with anemphasis on their suitability for nanomedicine. The biodistribution, toxicity, biocompatibility, cellular adhesion, and endocytosis of these nanostructures, when exposed to biological microenvironments, are examined in regard to their geometry, size, and surface chemistry. The final section focuses on recent biomedical applications of TiO 2 nanostructures, specifically evaluating therapeutic delivery, photodynamic and sonodynamic therapy, bioimaging, biosensing, tissue regeneration, as well as chronic wound healing.

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“…Later, after ball milling or ultrasonically breaking these films, one can obtain porous SiNPs. [118] In contrast to the above methods, a reducing agentassisted method has been proposed; this represents a low-cost and straightforward process for the synthesis of porous SiNPs, for example, Wilcoxon et al reduced SiCl 4 with LiAlH 4. [119] Another example is the approach used by Xu et al with NH 4 Br as a reducing agent to reduce NaSi salt for the scalable preparation of black porous SiNPs, which exhibited a high PCE of 33.6%.…”

Section: Carbon-based Materialsmentioning

confidence: 99%

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Wen

Tamarov

Happonen

et al. 2020

Advanced Therapeutics

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Inorganic photothermal agents (PTAs) have attracted considerable attention in cancer theranostics due to their unique features such as high photothermal conversion efficacy, excellent photothermal stability, and straightforward functionalization. The first part of this Review summarizes progress in methods for synthesizing PTAs, then considers in vitro photothermal evaluations, as well as in vivo photothermal-based applications that attempt to overcome different barriers in cancer theranostics. Next, a clinical trial with an inorganic PTA is described. The final part of the Review examines the challenges and possibilities for successful transfer of inorganic PTAs from the laboratory to the clinic.

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Applications of Zero-Valent Silicon Nanostructures in Biomedicine

Cited by 29 publications

References 156 publications

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

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