Applications of venom biodiversity in agriculture

Oliveira, Álvaro Sérgio; Fantinel, Antônio Luiz; Artuzo, Felipe Dalzotto; Oliveira, Letí­cia de; Singer, Rodrigo B.; Júnior, Mário Luiz Conte da Frota; Dewes, Homero; Talamini, Édson

doi:10.1016/j.bioeco.2021.100010

Cited by 4 publications

(5 citation statements)

References 66 publications

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“…It is important to highlight that, over the years, studies by Brazilian researchers have also shown that the study of the composition of snake venoms, including peptides, can be applied beyond pharmacology, for example, to understand the evolutionary relationships between different snake species and their distribution pattern throughout evolution [48]. About these applications, currently, the development of biopesticides for agricultural use from snake venom has also been studied [11]. It is important to highlight that proteomics techniques were used in most studies, that is, venom components such as proteins and peptides were separated, identified and characterized through techniques such as chromatography, electrophoresis and phylogenetic analysis [49][50].…”

Section: Temporal and Geographical Aspectmentioning

confidence: 99%

“…It is important to highlight that proteomics techniques were used in most studies, that is, venom components such as proteins and peptides were separated, identified and characterized through techniques such as chromatography, electrophoresis and phylogenetic analysis [49][50]. The knowledge gained from the use of proteomics (and other approaches such as genomics) allows the development of biotechnology from biological resources such as snake venoms to create more sustainable solutions for agriculture such as new crop varieties and biopesticides [11].…”

Section: Temporal and Geographical Aspectmentioning

confidence: 99%

“…The snake venoms composition varies according to factors such as gender, family, species, geographic location, type of prey, age and size of the individual [8][9]. Techniques called "omics", such as proteomics and transcriptomics, have enabled the understanding of the biochemistry and functionality of poisons, as well as their application in biotechnology, allowing the use of these poisons from drug development to agricultural application [10][11]. In Brazil, there are 392 species of snakes [12] found in many habitats and niches [13].…”

Section: Introductionmentioning

confidence: 99%

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Studies about Snake Peptides: a Review about Brazilian Contribution

Assis

Bittar

Amorim

et al. 2022

Braz. arch. biol. technol.

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The peptides present in snake venoms are studied because of their properties, constitutions, mechanisms of action and pharmacological potential. Recognizing this potential, the present study reports the contributions of Brazilian researchers about snake peptides, between 1975 and July 2020. Thus, this study serves as a basis for monitoring this theme in Brazil, referring to the trends and patterns of scientific production. The results indicated a significant increase in Brazilian scientific production over the years, highlighting institutions located in São Paulo state as, the Butantan Institute and University of São Paulo. The main journal where Brazilian authors publish their research is the Toxicon Journal. Collaborative networks were identified between Brazilian institutions and among other countries with Brazil. The most investigated species are found in brazilian territory, mainly those belonging to the genus Bothrops and the species Crotalus durissus. The increase in studies about this theme in Brazil is evident, however, a gap is highlighted for states outside the southeastern region and for other venomous species.

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Section: Temporal and Geographical Aspectmentioning

confidence: 99%

Section: Temporal and Geographical Aspectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Studies about Snake Peptides: a Review about Brazilian Contribution

Assis

Bittar

Amorim

et al. 2022

Braz. arch. biol. technol.

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“…Scorpion toxins specific for insect Na v s have been considered as one of the most promising options for insecticide [ 10 ] . Some scorpion toxins influence the sodium channels of insects but have no effect on mammalian sodium channels [ 3 ] .…”

Section: Introductionmentioning

confidence: 99%

Identification, Characterization, and Modeling of a Bioinsecticide Protein Isolated from Scorpion Venom gland: A Three-Finger Protein

Baradaran,

Mahdavinia,

Naderi Soorki

et al. 2023

IBJ

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Background: The majority of insecticides target sodium channels. The increasing emergence of resistance to the current insecticides has persuaded researchers to search for alternative compounds. Scorpion venom gland as a reservoir of peptides or proteins, which selectively target insect sodium channels. These proteins would be an appropriate source for finding new suitable anti-insect components. Methods: Transcriptome of venom gland of scorpion M. eupeus was obtained by RNA extraction and cDNA library synthesis. The obtained transcriptome was blasted against protein databases to find insect toxins against sodium channel based on the statistically significant similarity in sequence. Physicochemical properties of the identified protein were calculated using bioinformatics software. The 3D structure of this protein was determined using homology modeling, and the final structure was assessed by MD simulation. Results: The sodium channel blocker found in the transcriptome of M. eupeus venom gland was submitted to the GenBank under the name of meuNa10, a stable hydrophilic protein consisting of 69 amino acids, with the molecular weight of 7721.77 g/mol and pI of 8.7. The tertiary structure of meuNa10 revealed a conserved CS-alpha/beta domain stabilized by eight cysteine residues. The meuNa10 is a member of the 3FP superfamily consisting of three finger-like beta strands. Conclusion: This study identified meuNa10 as a small insect sodium channel-interacting protein with some physicochemical properties, including stability and water-solubility, which make it a good candidate for further in vivo and in vitro experiments in order to develop a new bioinsecticide.

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“…Their bioactive components are referred to as toxins and belong to the most potent and selective natural products known [ 4 ]. While this potency and selectivity, on the one hand, can cause potentially life-threatening envenoming (e.g., in the context of the global snakebite crisis [ 5 , 6 , 7 ]), the toxins of animal venoms and poisons may also be repurposed into biomedical, biotechnological or agricultural products [ 8 , 9 , 10 ]. Accordingly, animal venoms and poisons have been targeted in several biodiscovery programs, yet the majority of taxa and their biomolecular arsenal remain virtually unstudied [ 11 ].…”

mentioning

confidence: 99%