Applications of ultraviolet light in the preparation of platelet concentrates

Pamphilon, Derwood; Corbin, S. A.; Saunders, J.; Tandy, N. P.

doi:10.1046/j.1537-2995.1989.29589284134.x

Cited by 58 publications

(14 citation statements)

References 17 publications

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“…A series of studies confirmed that UVR irradiated lymphocytes were not able to induce allogeneic cells in a mixed lymphocyte culture (MLC) as first reported by Lindahl-Kiessling [48–50]. Clusters formed by specialized accessory cells such as dendritic cells (DC), after mitogenic or allogenic stimulation, were necessary for lymphocyte activation to occur.…”

Section: Mechanisms Of Action Of Ubimentioning

confidence: 53%

Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?

Hamblin

2016

Journal of Photochemistry and Photobiology B: Biology

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Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, the use of UBI declined and it has now been called “the cure that time forgot”. Later studies were mostly performed by Russian workers and in other Eastern countries, and the modern view in Western countries is that UBI remains highly controversial. This review discusses the potential of UBI as an alternative approach to current methods used to treat infections, as an immune-modulating therapy and as a method for normalizing blood parameters. Low and mild doses of UV kill microorganisms by damaging the DNA, while any DNA damage in host cells can be rapidly repaired by DNA repair enzymes. However the use of UBI to treat septicemia cannot be solely due to UV-mediated killing of bacteria in the bloodstream, as only 5–7% of blood volume needs to be treated with UV to produce the optimum benefit, and higher doses can be damaging. There may be some similarities to extracorporeal photopheresis (ECP) using psoralens and UVA irradiation. However there are differences between UBI and ECP in that UBI tends to stimulate the immune system, while ECP tends to be immunosuppressive. With the recent emergence of bacteria that are resistant to all known antibiotics, UBI should be more investigated as an alternative approach to infections, and as an immune-modulating therapy.

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Section: Mechanisms Of Action Of Ubimentioning

confidence: 53%

Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?

Hamblin

2016

Journal of Photochemistry and Photobiology B: Biology

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“…[47–49]. Clusters formed by specialized accessory cells after mitogenic or allogenic stimulation, with dendritic cells (DC) are necessary for lymphocyte activation to occur.…”

Section: Mechanisms Of Action Of Ubimentioning

confidence: 99%

Ultraviolet Irradiation of Blood: “The Cure That Time Forgot”?

Hamblin

2017

Advances in Experimental Medicine and Biology

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Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, UBI use declined and it has now been called “the cure that time forgot”. Later studies were mostly performed by Russian workers and in other Eastern countries and the modern view in Western countries is that UBI remains highly controversial. This chapter discusses the potential of UBI as an alternative approach to current methods used to treat infections, as an immune-modulating therapy and as a method for normalizing blood parameters. No resistance of microorganisms to UV irradiation has been reported, and multi- antibiotic resistant strains are as susceptible as their wild-type counterparts. Low and mild doses of UV kill microorganisms by damaging the DNA, while any DNA damage in host cells can be rapidly repaired by DNA repair enzymes. However the use of UBI to treat septicemia cannot be solely due to UV-mediated killing of bacteria in the blood-stream, as only 5–7% of blood volume needs to be treated with UV to produce the optimum benefit. UBI may enhance the phagocytic capacity of various phagocytic cells (neutrophils and dendritic cells), inhibit lymphocytes, and oxidize blood lipids. The oxidative nature of UBI may have mechanisms in common with ozone therapy and other oxygen therapies. There may be some similarities to extracorporeal photopheresis (ECP) using psoralens and UVA irradiation. However there are differences between UBI and ECP in that UBI tends to stimulate the immune system, while ECP tends to be immunosuppressive. With the recent emergence of bacteria that are resistant to all known antibiotics, UBI should be more investigated as an alternative approach to infections, and as an immune-modulating therapy.

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“…Our group has shown that the UVA alone does not contribute to the changes in aggregation response observed in INTERCEPT‐treated PLTs compared to untreated PLTs . The effect of UVB on PLTs is better documented as UVB radiation alone has been used to prevent alloimmunization and refractoriness to PLT transfusions caused by contaminating WBCs in PCs . These studies have shown significant differences in PLT aggregation for a UVB dose equal or superior to 3 J/cm 2 in response to collagen, ADP, and arachidonic acid activation .…”

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confidence: 99%

In vitro study of platelet function confirms the contribution of the ultraviolet B (UVB) radiation in the lesions observed in riboflavin/UVB‐treated platelet concentrates

et al. 2015

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The amotosalen/UVA-treated PCs confirmed previously published results with a slight increase of PSLs compared to untreated PCs. Riboflavin/UVB-treated PCs present significant in vitro PSLs compared to untreated PCs. These lesions are caused by the UVB radiation alone and probably involve the generation of reactive oxygen species. The impact of these observations on clinical use must be investigated.

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Applications of ultraviolet light in the preparation of platelet concentrates

Cited by 58 publications

References 17 publications

Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?

Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?

Ultraviolet Irradiation of Blood: “The Cure That Time Forgot”?

In vitro study of platelet function confirms the contribution of the ultraviolet B (UVB) radiation in the lesions observed in riboflavin/UVB‐treated platelet concentrates

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