Applications of surface‐enhanced Raman spectroscopy based on portable Raman spectrometers: A review of recent developments

Abstract

Recently, the surface‐enhanced Raman spectroscopy (SERS) technique emerges as a potential promising analytical tool for rapid, sensitive, and selective detection which can provide unique information about the substances in the presence of plasmonic nanostructures via finger‐printing SERS spectra. The progress in nanostructure SERS substrates and portable Raman spectrometers will promote this novel detection technique to play an important role in the future rapid on‐site assay. In this review, we summarized the latest research on SERS detection technique combined based on nanostructure SERS‐active substrates with portable Raman spectrometers and their potential on‐site detection applications in environment pollutants, agricultural pollutants, biomedical analysis, and other newly emerging fields (focusing particularly on the last 5 years of research). The future perspective of SERS for on‐site analysis is also discussed.

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

“…By contrast, a portable Raman spectrometer has the advantages of small size, low price, and on-site detection capacity. Compared with other large-scale Raman system-based ALP detection methods, our method utilized a portable Raman spectrometer, which has lower or equivalent detection sensitivity and shorter detection time, thus meeting the requirements of accurate and rapid clinical testing …”

“…Compared with other large-scale Raman system-based ALP detection methods, our method utilized a portable Raman spectrometer, which has lower or equivalent detection sensitivity and shorter detection time, thus meeting the requirements of accurate and rapid clinical testing. 40 The reproducibility and stability of SERS substrates are important indicators for the construction of sensors. To investigate the preparation reproducibility of the PAZ NP substrate preparation, Figure S7 shows a histogram of the difference of SERS intensity at 1075 cm −1 displacement for 5 different batches of PAZ NPs incubated with PBS (10 mM).…”

Place & Play SERS: sample collection and preparation-free surface-enhanced Raman spectroscopy

“…[1][2][3][4][5] Surface-enhanced Raman spectroscopy (SERS), a method for signicantly enhancing inherently weak Raman scattering by localized surface plasmon resonance and measuring the enhanced Raman scattering signal for nondestructive structural analysis of samples, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] is an effective tool to provide the ability by virtue of its high sensitivity (even down to single molecules) and rapid label-free signal detection (down to ∼1 s or less) as well as the availability of portable Raman spectrometers (down to the passport size and 0.5 kg). [24][25][26] SERS is advantageous over other analytical methods such as mass spectrometry, gas chromatography, liquid chromatography, laser-induced breakdown spectroscopy, and uorescence detection because these methods require bulky and costly equipment, are timeconsuming in sample collection and preparation, or lack the capability of nondestructive, multiplex detection. [1][2][3][4] In fact, SERS has been widely used in trace detection of hazardous chemicals, pesticide residues, microplastics, glucose in whole blood, viruses of infectious diseases, and controlled drugs.…”

“…[1][2][3][4] In fact, SERS has been widely used in trace detection of hazardous chemicals, pesticide residues, microplastics, glucose in whole blood, viruses of infectious diseases, and controlled drugs. 7,24,25 Unfortunately, the practical utility of SERS is limited because it generally requires sample collection and preparation, namely, collecting a sample from an object of interest and placing the sample on top of a SERS substrate to perform a SERS measurement (Fig. 1a).…”

“…The ability to perform sensitive, real-time, in situ , multiplex chemical analysis is indispensable for diverse applications such as human health monitoring, food safety testing, forensic analysis, environmental sensing, and homeland security. 1–5 Surface-enhanced Raman spectroscopy (SERS), a method for significantly enhancing inherently weak Raman scattering by localized surface plasmon resonance and measuring the enhanced Raman scattering signal for nondestructive structural analysis of samples, 6–25 is an effective tool to provide the ability by virtue of its high sensitivity (even down to single molecules) and rapid label-free signal detection (down to ∼1 s or less) as well as the availability of portable Raman spectrometers (down to the passport size and 0.5 kg). 24–26 SERS is advantageous over other analytical methods such as mass spectrometry, gas chromatography, liquid chromatography, laser-induced breakdown spectroscopy, and fluorescence detection because these methods require bulky and costly equipment, are time-consuming in sample collection and preparation, or lack the capability of nondestructive, multiplex detection.…”