Applications of Stem Cell Therapy for Physeal Injuries.

Sanghani, Anita; Chimutengwende-Gordon, Mukai; Adesida, Adetola B; Khan, Wasim

doi:10.2174/1574888x1130800063

Cited by 5 publications

(3 citation statements)

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“…153,269,270 FGF2 has also been used in combination with mesenchymal stem/progenitor cells to improve epiphyses repair. 271,272 Due to the anabolic effect of FGF8 in the degradation of cartilage ECM, neutralizing antibody against FGF8 can partially alleviate the OA progression. 236 Bone regeneration: Compared with the intervention of FGFRs, modulations of FGF signaling by ligands are closer to the clinical application.…”

Section: Bone Regeneration: Multiple Studies Have Demonstrated Thatmentioning

confidence: 99%

Section: Fgf Signaling In Skeleton Development and Repair/regeneratiomentioning

confidence: 99%

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FGF/FGFR signaling in health and disease

Xie

Yang

et al. 2020

Sig Transduct Target Ther

454

391

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Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

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Section: Bone Regeneration: Multiple Studies Have Demonstrated Thatmentioning

confidence: 99%

Section: Fgf Signaling In Skeleton Development and Repair/regeneratiomentioning

confidence: 99%

FGF/FGFR signaling in health and disease

Xie

Yang

et al. 2020

Sig Transduct Target Ther

454

391

View full text Add to dashboard Cite

show abstract

“…Therefore, future studies need to focus on functional regeneration in addition to the histological regeneration of growth plate. Following growth plate injury, the formation of bone bridge results in the loss of growth plate function, leading to limb length discrepancy and deformities (Sanghani et al, 2013). Implant materials aim to prevent bone bridge formation, but studies on tissue engineering composite materials and gels have revealed some degree of bone filling and growth plate closure in these treatments (Chen et al, 2003;Jin et al, 2006;Sundararaj et al, 2015), making it difficult to determine whether the mineralization of the defect area was normal bone closure or bone bridge remodeling.…”

Section: Discussionmentioning

confidence: 99%

3D bioprinted hydrogel/polymer scaffold with factor delivery and mechanical support for growth plate injury repair

Fan

Qiang

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Growth plate injury is a significant challenge in clinical practice, as it could severely affect the limb development of children, leading to limb deformity. Tissue engineering and 3D bioprinting technology have great potential in the repair and regeneration of injured growth plate, but there are still challenges associated with achieving successful repair outcomes.Methods: In this study, GelMA hydrogel containing PLGA microspheres loaded with chondrogenic factor PTH(1–34) was combined with BMSCs and Polycaprolactone (PCL) to develop the PTH(1–34)@PLGA/BMSCs/GelMA-PCL scaffold using bio-3D printing technology.Results: The scaffold exhibited a three-dimensional interconnected porous network structure, good mechanical properties, biocompatibility, and was suitable for cellchondrogenic differentiation. And a rabbit model of growth plate injury was appliedto validate the effect of scaffold on the repair of injured growth plate. The resultsshowed that the scaffold was more effective than injectable hydrogel in promotingcartilage regeneration and reducing bone bridge formation. Moreover, the addition ofPCL to the scaffold provided good mechanical support, significantly reducing limbdeformities after growth plate injury compared with directly injected hydrogel.Discussion: Accordingly, our study demonstrates the feasibility of using 3D printed scaffolds for treating growth plate injuries and could offer a new strategy for the development of growth plate tissue engineering therapy.

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FGF Signaling in Cartilage Development and Disease

Chen

Xie

et al. 2020

Encyclopedia of Bone Biology

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Applications of Stem Cell Therapy for Physeal Injuries.

Cited by 5 publications

References 0 publications

FGF/FGFR signaling in health and disease

FGF/FGFR signaling in health and disease

3D bioprinted hydrogel/polymer scaffold with factor delivery and mechanical support for growth plate injury repair

FGF Signaling in Cartilage Development and Disease

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