Applications of Selected Ion Flow Tube Mass Spectrometry, Sift-Ms, in Addiction Research

The increase of breath ammonia induced by niacin ingestion quantified by selected ion flow tube mass spectrometry

“…The use of our non-invasive breath analysis technique to investigate the metabolism of niacin may have applications in psychiatry research (Bloor et al 2005). In some persons suffering from schizophrenia the niacin flush does not occur and this anomaly can be helpful in classifying a subgroup of patients with schizophrenia who show evidence of altered phospholipid-dependent signal transduction, PDST (Hudson et al 1997).…”

“…These involve tests that quantify volatile compounds in breath without prior ingestion of food, a test substance or drug (e.g. Diskin et al (2003a)) and those that quantify compounds in breath after a meal (Smith et al 1999) and the administration of a drug or substance , Penault et al 2005, Bloor et al 2005. Our use of urea ingestion to detect the presence of Helicobacter pylori infection in the stomach via breath ammonia quantification Španěl 1996, Penault et al 2005) is an example of the latter approach, as is the approach taken to the study reported in the present paper using niacin (nictotinic acid) as the administered substance.…”

Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology

“…32,100,[104][105][106][107][108] The sensitivity of SIFT-MS and the mobility of the instrumentation have been greatly improved and now accurate on-line, real-time measurements of the concentrations of trace metabolites in exhaled breath can be made down to the ppbv level. 32,100,[104][105][106][107][108] The sensitivity of SIFT-MS and the mobility of the instrumentation have been greatly improved and now accurate on-line, real-time measurements of the concentrations of trace metabolites in exhaled breath can be made down to the ppbv level.…”