Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology

Španěl, Patrik; Smith, David

doi:10.1016/b978-0-44-462613-4.00004-0

Cited by 10 publications

(6 citation statements)

References 106 publications

(109 reference statements)

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“…Only a few volatile compounds in exhaled breath have been investigated in real-time measurements by PTR-MS [71][72][73], PTR-TOF-MS [74,75], SIFT-MS [76][77][78][79], laser spectrometry or sensors [80][81][82][83][84]: among them are isoprene, acetone, 2-pentanone, dimethylsulfide, methyl acetate [67], eucalyptol [85], hydrogen, methane [21,86], ethane [87,88], carbon monoxide [89][90][91][92][93], carbon dioxide ( 12 CO 2 and 13 CO 2 [94,95]), nitric oxide (NO) [96][97][98][99][100] and water (H 2 O and HDO [101,102]). In the future, real-time measurements should be performed for all volatile compounds, giving rise to the possibility of modelling the flow of these compounds within the human body as well as their production and rate of metabolism.…”

Section: Volatile Organic Compounds In Breathmentioning

confidence: 99%

A review of the volatiles from the healthy human body

et al. 2014

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A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urine (279), and faeces (381) in apparently healthy individuals. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been grouped into tables according to their chemical class or functionality to permit easy comparison. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces. Careful use of the database is needed. The numbers may not be a true reflection of the actual VOCs present from each bodily excretion. The lack of a compound could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from blood compared to a large number on VOCs in breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. collecting excretions on glass beads and then heating to desorb VOCs. All compounds have been included as reported (unless there was a clear discrepancy between name and chemical structure), but there may be some mistaken assignations arising from the original publications, particularly for isomers. It is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of VOCs from healthy individuals. Establishing a list of volatiles emanating from healthy individuals and increased understanding of VOC metabolic pathways is an important step for differentiating between diseases using VOCs.

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Section: Volatile Organic Compounds In Breathmentioning

confidence: 99%

A review of the volatiles from the healthy human body

et al. 2014

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“…The analysis of exhaled metabolites in breath is an attractive approach to monitor health status and therapeutic intervention. 51 Selected ion ow tube mass spectrometry (SIFT-MS) 52 and proton transfer reaction mass spectrometry (PTR-MS) 53 are two well established methods for real-time detection of volatiles in breath. One of the main strengths of SIFT-MS is its capability to provide absolute quantications of trace gases in the partsper-million to parts-per-billion range.…”

Section: Breath Analysismentioning

confidence: 99%

Secondary electrospray ionization proceeds via gas-phase chemical ionization

2017

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“…Only a few volatiles are easily detected and are unambiguous, since their breath abundances are especially high. In the breath of healthy volunteers, concentrations of acetone vary around a median value of 600 ppbv [74], isoprene levels range from 6 to 275 ppbv (mean: 99 ppbv) [65,75] and methanol has a median value of 460 ppbv [75,76]. Moreover, ammonia was reported to range from 248 to 2935 ppbv (geometric mean: 833) [75,76].…”

Section: Analysis Of Breath Acetone By Aimsmentioning

confidence: 99%

“…In the breath of healthy volunteers, concentrations of acetone vary around a median value of 600 ppbv [74], isoprene levels range from 6 to 275 ppbv (mean: 99 ppbv) [65,75] and methanol has a median value of 460 ppbv [75,76]. Moreover, ammonia was reported to range from 248 to 2935 ppbv (geometric mean: 833) [75,76]. Reference ranges have been established for several common breath metabolites using SIFT-MS [39] and the origin of these compounds (systemic or oral cavity generated) has been identified by the analyses of mouthexhaled and nose-exhaled breath [77,78].…”

Section: Analysis Of Breath Acetone By Aimsmentioning

confidence: 99%

Near real-time VOCs analysis using an aspiration ion mobility spectrometer

et al. 2013

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The ChemPro 100i chemical detector (aspiration-type ion mobility spectrometer) was used for the detection of selected volatile organic compounds known to be potential indicators of human presence. The targeted group of compounds mainly comprised ketones (acetone, 2-butanone, 2-pentanone, 3-methyl-2-butanone, 4-heptanone), aldehydes (propanal, pentanal, hexanal, octanal), dimethyl disulfide (DMDS), isoprene and ethanol. Gaseous standards of these compounds were produced from pure substances and analysed using the aspiration ion mobility spectrometry (AIMS) chemical detector. The chemical fingerprints obtained (patterns) were compared to evaluate possible differences in responses. The limits of detection ranged from 5 ppbv for 4-heptanone to 87 ppbv for DMDS, whereas relative standard deviations varied from 1.5% to 5%. Additionally, quantitative AIMS measurements of acetone levels in human breath samples were carried out. The breath acetone levels measured with AIMS ranged from 290 to 540 ppbv and correlated quite well with the SPME-GC-MS results, showing limited potential of AIMS for the detection of breath acetone; however, deviations were observed for concentrations above 500 ppbv. The further success of AIMS in breath analysis depends on improvements of the analytical power (e.g. selectivity, sensitivity, resolution) and the implementation of multivariate data analysis techniques.

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Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology

Cited by 10 publications

References 106 publications

A review of the volatiles from the healthy human body

A review of the volatiles from the healthy human body

Secondary electrospray ionization proceeds via gas-phase chemical ionization

Near real-time VOCs analysis using an aspiration ion mobility spectrometer

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