Applications of Polymethylhydrosiloxane (PMHS) in Organic Synthesis- Covering up to March 2022

Abstract

Based on the type of metal or non-metal catalyst used, the authors of this paper have clearly highlighted the different applications of air stable, commercially viable, and environmentally friendly polymethylhydrosiloxane (PMHS) in organic synthesis or other allied reactions. The importance of PMHS was emphasised for the particular organic transformation's success. In addition to its well-known use as a reducing agent, it has also been demonstrated in a variety of other applications, including ring cleavage, the cotton industry, functional material for microfluidic chips, and the dehydroaromatization of bio-oils. The article tries to compile the most noteworthy cases of highly successful PMHS catalysis over the past two decades or so.

Recent advances in TBHP‐promoted heterocyclic ring construction via annulation/cyclization

“…A thorough analysis of several synthetic methodologies that produced (C C), (C N), and (C S) bonds utilizing the I 2 /TBHP reagent system was compiled by Kapoor et al between 2010 and 2021 [14]. In keeping with our interest in investigating the uses of redox reagents [15][16][17][18][19][20][21][22][23][24], as of right now, there is not a thorough and critical evaluation of the literature on the applications of TBHP in heterocyclic ring formations. In this update, we discuss the most notable contributions of TBHP that have documented the scope of the reaction and provided mechanistic insights in heterocyclic ring formations from 2018 to date.…”

“…On the other hand, iminium cations 17 could be produced by iodinating N-substituted indoles at the C-3 position. 18 may also be obtained by intramolecular trapping using a sulfonamide tether (17)(18)(19)(20) and elimination. The likelihood of a C-3-iodination pathway for Nunsubstituted indoles could not be entirely ruled out by the authors.…”