Applications of novel drug delivery system for herbal formulations

AJAZUDDIN, .; Saraf, Shailendra

doi:10.1016/j.fitote.2010.05.001

Cited by 447 publications

(163 citation statements)

References 61 publications

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“…15 Presently, the application of SLNs as carriers in facilitating the absorption of the active ingredient in traditional Chinese medicine, such as silymarin, triptolide, and paclitaxel, has been actively studied. 16 We postulated that BBR loaded SLNs (BBR-SLNs) with an absorption enhancer may increase the absorption and bioavailability of BBR and attenuate its adverse effects. Therefore, the aim of the present study was to investigate the pharmacokinetic characteristics and the antidiabetic actions of BBR-SLNs, and thus provide new strategies in facilitating BBR's clinical applications.…”

mentioning

confidence: 99%

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

Xue¹,

Yang²,

Zhang³

et al. 2013

IJN

114

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The high aqueous solubility, poor permeability, and absorption of berberine (BBR) result in its low plasma level after oral administration, which greatly limits its clinical application. BBR solid lipid nanoparticles (SLNs) were prepared to achieve improved bioavailability and prolonged effect. Developed SLNs showed homogeneous spherical shapes, small size (76.8 nm), zeta potential (7.87 mV), encapsulation efficiency (58%), and drug loading (4.2%). The power of X-ray diffraction combined with 1 H nuclear magnetic resonance spectroscopy was employed to analyze chemical functional groups and the microstructure of BBR-SLNs, and indicated that the drug was wrapped in a lipid carrier. Single dose (50 mg/kg) oral pharmacokinetic studies in rats showed significant improvement ( P <0.05) in the peak plasma concentration, area under the curve, and variance of mean residence time of BBR-SLNs when compared to BBR alone ( P <0.05), suggesting improved bioavailability. Furthermore, oral administration of both BBR and BBR-SLNs significantly suppressed body weight gain, fasting blood glucose levels, and homeostasis assessment of insulin resistance, and ameliorated impaired glucose tolerance and insulin tolerance in db/db diabetic mice. BBR-SLNs at high dose (100 mg/kg) showed more potent effects when compared to an equivalent dose of BBR. Morphologic analysis demonstrated that BBR-SLNs potentially promoted islet function and protected the islet from regeneration. In conclusion, our study demonstrates that by entrapping BBR into SLNs the absorption of BBR and its anti-diabetic action were effectively enhanced.

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mentioning

confidence: 99%

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

Xue¹,

Yang²,

Zhang³

et al. 2013

IJN

114

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“…Novel drug delivery systems, such as nanotechnological, provide several advantages over traditional forms including the enhancement of solubility, bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability (Ajazuddin, 2010) and controlled release of biomarkers (Devi, Jain, Valli, 2010;Summerlin et al, 2015). Antioxidant capacity can provide protection from endogenous and exogenous oxidative stresses by scavenging free radicals.…”

Section: Resultsmentioning

confidence: 99%

Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion

Fonseca-Santos

Funagoshi

Oliveira

et al. 2017

Braz. J. Pharm. Sci.

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This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations; where in the addition of the extract did not change rheological behavior of the formulations. All of the formulations were stable in the period analyzed and presented higher bioadhesive strength. In vitro antioxidant activity suggests that LCS and MEs presented a high capacity to maintain the antioxidant activity of OC extract. The results showed that the incorporation of OC in LCS improved the safety profile, according to cytotoxicity assays of systems may be a promising platform to OC extract for topical application for the potential treatment of skin disorders. Keywords:Liquid crystals/evaluation/physical-chemical stability. Microemulsions/evaluation. Surfactant-based system. Organic cocoa extract. Skin bioadhesion. INTRODUCTIONSkin is routinely exposed to stressful environmental factors such as pollutants and UV radiation. These factors produce a large number of aggressive oxidants that damage all of the biological skin cell membranes (Silva et al., 2010;Binic et al., 2013;Datta et al., 2011;Dupont, Gomez, Bilodeau, 2013). Accordingly, the use of skin care products and cosmetics has been utilized to mitigate the cutaneous photoaging process (Visscher, Pan, Kitzmiller, 2013) and these products are commonly composed of plant extracts (Binic et al., 2013).A great number of plants and plant extracts are studied for their antioxidative action arising from their phenolic substructures. Phenolic compounds are composed of an aromatic ring that is linked to a hydroxyl group, which donates electrons and hydrogen atoms. As a result, these compounds are exceptional antioxidants (Silva et al., 2010;Binic et al., 2013;Reuter, Merfort, Schempp, 2010).Cocoa, the dried and fermented seeds derived from Theobroma cacao, has been consumed since 1100 B.C. by ancient civilizations such as the Mayans and Aztecs (Hurst et al., 2002). Cocoa contains high amounts of the flavonoids (−)-epicatechin (EC) and (+)-catechin, and procyanidins B2 and B1. Additionally, other polyphenols such as quercetin, isoquercitrin (quercetin 3-O-glucoside), quercetin 3-O-arabinose, hyperoside (quercetin 3-O-galactoside), naringenin, luteolin, and apigenin have also been found in cocoa in minor quantities (Sánchez-Rabaneda et al., 2003). While the natural amount B. Fonseca-Santos, E. E. Funagoshi, J. R. S. Olivei...

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“…They have gained much attention in food and health promotion products including cosmetics (Saraf, 2010), but particularly those of edible oil containing nonionic surfactants (Li et al, 2012;Polychniatou and Tzia, 2014). Micro-emulsions and nano-emulsions are the most widely used terms for nano-particle emulsions which differ in stability and formulation methods (McClements, 2012).…”

Section: Introductionmentioning

confidence: 99%

Preparation of stable tea seed oil nano-particle emulsions by a low energy method with non-ionic surfactants

Kanlayavattanakul

Lourith

2017

Grasas y Aceites

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SUMMARY:Tea seed oil nano-particle emulsions were prepared. Non-ionic surfactants containing Tween 80 and Span 80 (1:1, w/w) were mixed with propanol (3-9:1, w/w) to give S mix , which was thereafter mixed with tea seed oil. The mixture was titrated with water at 150 rpm to give clear or bluish and bluish-white emulsions. Twelve nano-particle emulsions with 64.64 to 72.73% S mix , 16.66 to 27.27% oil and 9.09 to 16.67% water with particle sizes between 207.00 to 430.10 nm, PDI of 0 to 0.4, z-potential of -42.00 to -49.63 mV, pH of 7.04 to 7.32 and 151.33 to 241.93 cps, were stable following an accelerated stability test and long term storage at room temperature and 4 and 45 ºC for 90 days, although one system (16.66% oil and 66.67% S mix ) was separated. This nano-particle emulsion formulation is concise and feasible for an industrial development of topical products containing tea seed oil.KEYWORDS: Camellia oleifera; Emulsion; Formulation; Self-emulsifying; Stability; Tea seed oil RESUMEN: Preparación de emulsiones estables de nanopartículas de aceite de semilla de té mediante un método de baja energía con tensioactivos no iónicos. Se prepararon emulsiones de nanopartículas de aceite de semilla de té. Se mezclaron tensioactivos no iónicos que contenían Tween 80 y Span 80 (1:1, p/p) con propanol (3-9: 1, p/p) para dar S mix que después se mezcló con aceite de semilla de té. La mezcla se valoró con agua a 150 rpm para dar emulsiones claras o azuladas y blanco azulado. Doce emulsiones de nanopartículas con 64,64 a 72,73% de S mix , 16,66 a 27,27% de aceite y 9,09 a 16,67% de agua con tamaños de partícula entre 207,00 y 430,10 nm, PDI de 0 a 0,4, potencial z de -42,00 a -49,63 mV, PH de 7,04 a 7,32 y 151,33 a 241,93 cps, se mantuvieron estables tras el ensayo de estabilidad acelerada y almacenamiento a largo plazo a temperatura ambiente y 4 y 45 ºC durante 90 días, aunque uno de los sistemas (16,66% de aceite y 66,67% de S mix ) se desvió. Esta formulación de emulsión de nanopartículas es concisa y factible para un desarrollo industrial de productos tópicos que contienen aceite de semilla de té. Citation/Cómo citar este artículo: Kanlayavattanakul M, Lourith N. 2017. Preparation of stable tea seed oil nanoparticle emulsions by a low energy method with non-ionic surfactants. Grasas Aceites 68 (2), e196. http://dx.doi.

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Applications of novel drug delivery system for herbal formulations

Cited by 447 publications

References 61 publications

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion

Preparation of stable tea seed oil nano-particle emulsions by a low energy method with non-ionic surfactants

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