Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine

Duman, Fatma Demir; Forgan, Ross S.

doi:10.1039/d1tb00358e

Cited by 85 publications

(49 citation statements)

References 171 publications

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“…1,2 These materials have been successfully applied with manifold purposes such as gas storage/separation, drug delivery, catalysis, chemical sensing, and water treatment. 1,3,4…”

Section: Introductionmentioning

confidence: 99%

High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

et al. 2022

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“…1,2 These materials have been successfully applied with manifold purposes such as gas storage/separation, drug delivery, catalysis, chemical sensing, and water treatment. 1,3,4…”

Section: Introductionmentioning

confidence: 99%

High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

et al. 2022

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“…7-12.5 nm [6]. A large number of pores, channels, and cavities in MOFs provide the therapeutic agents with excellent carriers for the delivery of proteins, drugs, genes, Deoxyribonucleic acid (DNA), and ribonucleic acid (RNA) through covalent and non-covalent interactions [7,8]. Nevertheless, optimizing pore size for controlled release behavior depends on several parameters, mainly the interaction between drug and framework.…”

Section: Strategies For Encapsulation Of Cargo Into Mofsmentioning

confidence: 99%

Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery

et al. 2021

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The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m2·g−1). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during the past decade, in parallel with the evolution in the use of porous nanomaterials in biomedicine. Compared to other nanoparticle-based delivery systems, such as porous nanosilica, nanomicelles, and dendrimer-encapsulated nanoparticles, NMOFs are more flexible, have a higher biodegradability potential, and can be more easily functionalized to meet the required level of host–guest interactions, while preserving a larger and fully adjustable pore window in most cases. Due to these unique properties, NMOFs have the potential to carry anticancer cargos. In contrast to almost all porous materials, MOFs can be synthesized in diverse morphologies, including spherical, ellipsoidal, cubic, hexagonal, and octahedral, which facilitates the acceptance of various drugs and genes.

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“…Nanoscale MOFs have been investigated for their possible use in a variety of applications such as X-ray computed tomography imaging (CT imaging) as contrast agents with the addition of high atomic number elements as their building blocks [ 119 ]. Meanwhile, Cu 2+ and Zn 2+ were employed as metal parts along with 2,3,4,5,6-tetraiodo-1,4-benzenedicarboxylate (I4-BDC) as bridging ligands for the fabrication of iodinated nanoscale metal-organic frameworks [Cu(I4-BDC) (H 2 O)2] ·2H 2 O and [Zn(I4-BDC)- (EtOH)2] ·2EtOH, respectively.…”

Section: Applications Of Zn-based Mofs For Gases Adsorption Imaging and Sensorsmentioning

confidence: 99%

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Ali

Meng

2021

Molecules

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The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality. This review summarizes the methodology for fabricating ultrasensitive and selective Zn-MOF-based sensors, as well as their application in early cancer diagnosis and therapy. This review also offers a systematic approach to understanding the development of MOFs as efficient drug carriers and provides new insights on their applications and limitations in utility with possible solutions.

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Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine

Abstract: Nanoscale metal-organic frameworks (NMOFs) are an interesting and unique class of hybrid porous materials constructed by the self-assembly of metal ions/clusters with organic linkers. The high storage capacities, facile synthesis,...

Cited by 85 publications

References 171 publications

High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

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