Applications of nanomedicine in parasitic diseases

Abaza, Sherif

doi:10.4103/1687-7942.192997

Cited by 21 publications

(13 citation statements)

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“…Nanomedicine is a nanotechnology application for treatment, monitoring, prevention, and control of biological diseases (Abaza, 2016). Nanoparticles (NPs) of some metals or metal oxides are now widely used as drugs to treat different diseases and improve human health due to their antimicrobial actions; these NPs with specific chemical and physical features have shown anti-bacterial, antiviral and anti-parasitic actions against these pathogens (Tran and Webster, 2011, Jebali and Kazemi, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis

Dkhil

Khalil

Diab

et al. 2019

Saudi Journal of Biological Sciences

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Nanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the poor effect of the drug on the parasite juveniles and immature worms, and the emergence of drug resistant strains of Schistosoma. The present study aimed to examine the curative roles of both gold and selenium nanoparticles on jejunal tissues of mice infected with Schistosoma mansoni. Transmission electron microscopy was used for characterization of nanoparticles. Gold nanoparticles of 1 mg/kg mice body weight and selenium nanoparticles 0.5 mg/kg body weight were inoculated separately into mice infected with S. mansoni. The parasite induced a significant decrease in glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly increased. Additionally, the parasite introduced deteriorations in histological architecture of the jejunal tissue. Treatment of mice with metal nanoparticles reduced the levels of body weight changes, oxidative stress and histological impairment in the jejunal tissue significantly. Therefore, our results revealed the protective role of both selenium and gold nanoparticles against jejunal injury in mice infected with S. mansoni.

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Section: Introductionmentioning

confidence: 99%

Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis

Dkhil

Khalil

Diab

et al. 2019

Saudi Journal of Biological Sciences

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“…Nanomedicine is the nanotechnology implementation for diagnosis, treatment, prevention and control of diseases (Abaza, 2016). Silver nanoparticles (Ag NPs) proved effective against both extracellular and intracellular parasites (Adeyemi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and Immuno-Modulatory Effect of Silver Nanoparticles-Loaded With Metronidazole on Experimental Blastocystosis

Ahmed

Kamal

Mohamed

et al. 2021

Journal of the Egyptian Society of Parasitology

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“…In the recent decade, nanoparticles (NPs) due to their de ned properties have gained lots of attention and considerable interest which makes them a favorable candidate for anthelmintic application since present antiparasitic drugs have some side effects and their e cacy is not fully proved. Among a wide variety of nanoparticles, Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in the biomedical application and created the mass reports in the last years [4,11]. Notably, dramatic consideration was toward the biomedicine-related appraisal of AgNPs that rst invited worldwide consideration as eccentric antimicrobial, antifungal, and antiviral agents.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Assessment of Anthelmintic Activities of AgO Nanoparticle in Comparison to Closantel Against Liver Fluke Dicrocoelium Dendriticum

Arbabi

Haddad

HosseipourMashkani

et al. 2021

Preprint

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Background: Dicrocoeliasis is a rare Food-Born parasitic disease of the grazing herbivores as well humans, caused by Dicrocoelium dendriticum making severe pathological changes of the liver and bile systems, and therapeutic options for treatment are limited. With the appearance of drug resistance in liver flukes, there is a need to focus on alternative approaches to control helminth parasites of veterinary importance. Because of low-performance medications; drug delivery poses a great challenge for better treatment of Dicrocoeliasis. The current study aims to determine the anthelmintic properties of silver oxide nanoparticles (AgO) as a new method in dicrocoeliasis treatment, in vitro assay.Methods: The impacts of various concentrations of AgO nanoparticles (50-200 µg/ml) for 12-24 hours were compared with the Closantel, as the chemical drug. The anthelmintic efficacy was measured by scanning electron microscopy (SEM) technique.Results: SEM images of treated worms by AgO (200 µg/ml) showed severe damage, including complete loss of sensory papillae and destruction of prominent network structures and tegument vesicles. The mortality rates how the anthelmintic properties of AgO were highly relied on time and concentration, as far as increasing the time and concentration cause increasing the mortality rate. According to the MTT assay, the toxicity of AgO, at concentrations, 800 µg/ml is 8.7 %. Conclusions: Hence, it could be concluded that AgO NPs performed anthelmintic properties effects. To the best of our knowledge, no previous reports have assessed the effect of AgO NP on liver fluke D.dendriticum. Therefore, the present study provides a basis for future research on the control of this common trematode.

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Applications of nanomedicine in parasitic diseases

Cited by 21 publications

References 1 publication

Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis

Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis

Therapeutic and Immuno-Modulatory Effect of Silver Nanoparticles-Loaded With Metronidazole on Experimental Blastocystosis

In Vitro Assessment of Anthelmintic Activities of AgO Nanoparticle in Comparison to Closantel Against Liver Fluke Dicrocoelium Dendriticum

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