Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis

Abstract

Nanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the poor effect of the drug on the parasite juveniles and immature worms, and the emergence of drug resistant strains of Schistosoma. The present study aimed to examine the curative roles of both gold and selenium nanoparticles on jejunal tissues of mice infected with Schistosoma mansoni. Transmission electron microscopy was used for characterization of nanoparticles. Gold nanoparticles of 1 mg/kg mice body weight and selenium nanoparticles 0.5 mg/kg body weight were inoculated separately into mice infected with S. mansoni. The parasite induced a significant decrease in glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly increased. Additionally, the parasite introduced deteriorations in histological architecture of the jejunal tissue. Treatment of mice with metal nanoparticles reduced the levels of body weight changes, oxidative stress and histological impairment in the jejunal tissue significantly. Therefore, our results revealed the protective role of both selenium and gold nanoparticles against jejunal injury in mice infected with S. mansoni.

Myco-Synthesized Molluscicidal and Larvicidal Selenium Nanoparticles: A New Strategy to Control Biomphalaria alexandrina Snails and Larvae of Schistosoma mansoni with an In Silico Study on Induced Oxidative Stress

“…Similarly, Alkhudhayri et al [ 67 ] found that Se NPs have anti-coccidial, anti-apoptotic, and anti-inflammatory effects against the Eimeria parasite in the jejunum of mice. Furthermore, Se nanoparticles showed promising protective roles against mice infected with Schistosoma mansoni [ 68 ]. Comparing the Se nanoparticles’ activity against meracidia and cercariae, the present results showed a faster mortality rate of cercariae than the meracidial rate.…”

The Advancing of Selenium Nanoparticles Against Infectious Diseases

“…Se NPs are found to be more effective than sodium selenite with regard to their anti-coccidial, anti-oxidant, anti-apoptotic and anti-inflammatory role against Eimeria parasite in the jejunum of mice (Alkhudhayri et al, 2018;Alkhudhayri et al, 2020). Furthermore, Dkhil et al demonstrated the protective roles of Se NPs in mice infected with Schistosoma mansoni, indicating that Se NPs could possess therapeutic anti-schistosomal activity in the treatment of intestinal schistosomiasis (Dkhil et al, 2019). Additionally, biogenic Se NPs were also found to show anti-Toxoplasma effects against Toxoplasma gondii in mice with no considerable toxicity, demonstrating the therapeutic effects of Se NPs for toxoplasmosis in vivo (Keyhani et al, 2020a;Keyhani et al, 2020b;Shakibaie et al, 2020).…”

A Novel Treatment of Schistosomiasis: Nano-Calcium Silicate Incorporating 5% Copper Oxide

“… 33 Lately, Dkhil et al concluded the curative effects of NPs related to their antioxidant activities; consequently, they proved their anti-schistosomal activities in mice. 34 Oliveira et al proposed different strategy to prompt protection against S. mansoni infection by creating a vaccine founded on chitosan nanoparticles together with the antigen SmRho coated with alginate. 35 It was capable of modulating the granuloma area that signifies the major pathological response in schistosomiasis and also to encourage the defense against infection S. mansoni .…”