Applications of Microbes in Antibiotics

Cobongela, S.Z.Z.

doi:10.1007/978-981-16-2225-0_25

Cited by 2 publications

(3 citation statements)

References 103 publications

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“…According to the World Health Organization, infectious illnesses are still the second biggest cause of mortality worldwide [ 3 ]. The demand for novel antimicrobial agents and antibiotics, on the other hand, is higher than ever [ 4 – 6 ]. Pathogenic infections are continually evolving in terms of genetic characteristics, complicating the development of antibiotics and vaccines against infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Mentha piperita and Lavandula multifida are widely used in Moroccan traditional medicine for the treatment of diabetes and infectious diseases. The aims of this work were the determination of the chemical composition of Mentha piperita (MPEO) and Lavandula multifida (LMEO) essential oils and the evaluation of their antibacterial, antioxidant, and antidiabetic activities. The chemical composition was determined by GC-MS analysis. The antibacterial effects were evaluated against several bacterial strains using disc diffusion, MIC, and MBC methods. The antioxidant activity was evaluated in vitro using DPPH, H2O2, and xanthine oxidase, and the antidiabetic activity was estimated by the inhibitory effects of α-amylase, α-glucosidase, and lipase activities. GC-MS results showed that the main compounds of MPEO were menthone (29.24%), levomenthol (38.73%), and eucalyptol (6.75%). However, eucalyptol (28.11%), 2-bornanone (11.57%), endo-borneol (7.82%), and linalyl acetate (5.22%) are the major compounds of LMEO. The results exhibited important inhibitory effects against some bacterial strains with MIC = MBC = 0.39 mg/mL for MPEO against Staphylococcus aureus ATCC. However, LMEO exhibited remarkable antioxidant and antidiabetic activities compared to MPEO. Indeed, LMEO inhibited DPPH, H2O2, and xanthine oxidase with concentrations of 15.23, 21.52, and 8.89 µg/mL, respectively. Moreover, LMEO exhibited α-amylase and α-glucosidase at IC50 = 85.34 and IC50 = 59.36 µg/mL, respectively. The findings showed that both MPEO and LMEO exhibit promising biological properties. However, the application of these species or their main bioactive compounds requires further investigation.

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Section: Introductionmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Soil microbes, such as fungi and bacteria control the ecosystem by decomposition and maintain the health of the ecosystem. The majority of the currently used drugs are derived from the soil microorganisms belonging to the genera Bacillus, Streptomyces, Micromonospora, Penicillium, and Cephalosporium [42]. More than 500 bioactive compounds are discovered every year among which almost 60% is obtained from the soil microbes [43,44].…”

Section: Soil Microorganismsmentioning

confidence: 99%

“…It has been used for a variety of applications ranging from crop production to drug discovery. Members of the genus Bacillus are commonly found in soil and produce a variety of bioactive secondary metabolites that are effective against a variety of life-threatening diseases [42]. As per literature, many bacterial strains isolated from soil samples, for example, Bacillus pumillus, Bacillus lentus, Enterobacter aerogenes, Bacillus alvei, Micrococcus roseus, and Bacillus amyloliquefaciens have shown strong bioactivity against the various pathogens [48][49][50].…”

Section: Soil Bacteriamentioning

confidence: 99%

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Kumar¹,

Kumaresan²

2023

J App Biol Biotech

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The majority of natural products currently used in the medical field are derived from microbial or plant sources. The bioactive compounds derived from natural sources exhibit tremendous structural and chemical diversity. According to previous research, only a small percentage of the world's plant and microbial diversity has been examined for bioactivities. The compounds originating from secondary metabolites of microorganisms are more useful for the development of novel drugs due to their biological friendliness and drug-likeness than any other compounds. Thus, recent research suggests that microorganisms obtained from diverse habitats and natural resources offer various bioactive secondary metabolites with incredibly wider chemical entities, hopefully, an alternative remedy for many diseases. Soil bacteria are capable of producing a variety of natural bioactive compounds for the treatment of various diseases. The three genera Bacillus spp., Streptomyces spp., and Pseudomonas spp. have been the prime focus to produce different types of antibiotics. However, to date, there are no reviews that evaluated the antimicrobial and anticancer properties of soil bacterial metabolites. Hence, the current review aimed to assess the antimicrobial and anticancer potential of soil bacterial metabolites.

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Applications of Microbes in Antibiotics

Cited by 2 publications

References 103 publications

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

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