Applications of innovative technologies to the delivery of antipsychotics

Bergonzi, Maria Camilla; Bilia, Anna Rita; Landucci, Elisa

doi:10.1016/j.drudis.2021.09.019

Cited by 5 publications

(3 citation statements)

References 184 publications

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“…The common way of consuming psychotic drugs, through injectable and oral administration (tablets, capsules, syrups), has its limitations. Some limitations of antipsychotic drugs include the poor bioavailability (because of the large first-pass metabolism); poor solubility; inability to pass through the blood–brain barrier (BBB) in sufficient amounts to exert their therapeutic effect; low plasma half-life; high metabolic clearance; and significant adverse side effects [ 19 ]. On the other hand, oral administration is the most commonly used manner for frequent administrations, but not for emergencies.…”

Section: Oral Film Application In Mental Disordersmentioning

confidence: 99%

“…On the other hand, oral administration is the most commonly used manner for frequent administrations, but not for emergencies. Injectable administration is preferred for emergencies because of its quick response [ 19 ]. One significant disadvantage is the invasiveness of this methodology, which can reduce patient compliance, and requires a qualified person for administration.…”

Section: Oral Film Application In Mental Disordersmentioning

confidence: 99%

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Overview about Oral Films in Mental Disorders

2023

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Mental disorders are increasing worldwide, and efforts have been developed by multidisciplinary research groups to combine knowledge from different areas such as psychology, neuroscience, medicine, and biotechnology to develop strategies and products to promote the prevention of mental disorders. Excessive antipsychotic consumption is a public health problem, and innovative strategies must be devised. The development of innovative and, if possible, natural products is one of the strategies to combat this public health problem. Oral films are recent delivery systems that have been developed with several advantages that should be applied in this area. This review intends to draw attention to these new dosage forms of drugs and bioactive molecules pertinent to the field of mental health prevention and therapy and to the need for regulatory guidelines to ensure their quality and safety. This is a critical overview about strengths, weaknesses, opportunities, and threats related to oral film implementation in mental disorder treatment.

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Section: Oral Film Application In Mental Disordersmentioning

confidence: 99%

Section: Oral Film Application In Mental Disordersmentioning

confidence: 99%

Overview about Oral Films in Mental Disorders

2023

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“…Therefore, nano-phytomedicine offers great promise for solving problems associated with herbal medicine [ 11 ]. Drug delivery systems are used to improve the solubility and increase the bioavailability of poorly water-soluble drugs [ 12 , 13 ]. In recent years, numerous techniques have been developed to improve the oral bioavailability of poorly water-soluble drugs, including mesoporous silica, microemulsions [ 14 ], self-nano-emulsifying drug delivery systems [ 15 ], liquid crystalline nanoparticles [ 16 ], nanoengineered mucopermeating drug delivery systems [ 17 ], and lipid nanoparticles [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Microemulsions Enhance the In Vitro Antioxidant Activity of Oleanolic Acid in RAW 264.7 Cells

Stefani

Vasarri²,

Salvatici³

et al. 2022

Pharmaceutics

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Oleanolic acid (OA) is the main triterpenic acid of olive leaves known for numerous pharmacological properties, including antioxidant activity. However, it is poorly soluble in water and consequently with low bioavailability, which limits its pharmacological application. Microemulsions (MEs) are dispersed systems consisting of two immiscible phases that promote rapid solubilization and absorption in the gastrointestinal tract. To improve both solubility and intestinal permeability of this molecule, OA has been formulated in two different microemulsions (ME-1 and ME-2). A solubility screening was carried out to select the ME components, and pseudoternary phase diagrams were constructed to evaluate the region of existence and select the appropriate amount of the constituents. ME-1 was prepared using Capmul PG-8/NF as the oily phase, and Transcutol and Tween 20 (7:3) as surfactants, while ME-2 contained Nigella oil and Isopropil myristate as the oily phase, and Transcutol HP and Cremophor EL (2:1) as surfactants. The OA solubility was increased by 1000-fold and 3000-fold in ME-1-OA and ME-2-OA, respectively. The MEs’ droplet size and the PdI were evaluated, and the stability was assessed for 8 weeks by monitoring chemical and physical parameters. The parallel artificial membrane permeability assay (PAMPA) also demonstrated an enhanced intestinal permeability of both OA formulations compared with free OA. The potential ability of both MEs to enhance the bioactivity of OA against LPS-induced oxidative stress in RAW 264.7 murine macrophages was also investigated. Overall, this study suggests that both MEs promote a bio-enhancement of the protective action of OA against the LPS-induced pro-oxidant stress in macrophages. Overall, this study suggests that MEs could be an interesting formulation to improve OA oral bioavailability with potential clinical applications.

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