Applications of indocyanine green in surgery: A single center case series

Ahmed, Talha; Pai, M. M. Manohara; Mallik, Esha; Varghese, George; Ashish, Sharad; Acharya, Abhijith; Krishna, A.

doi:10.1016/j.amsu.2022.103602

Cited by 6 publications

(10 citation statements)

References 30 publications

(43 reference statements)

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“…Further prospective large studies are required before standardization of care focusing on the incidence of BDI, time to visualization of biliary anatomy, and outcomes when ICG fails to help identify. A Summary of literature pertaining to the utility of ICG for anatomical mapping is provided in Table 1 ( 24 , 29 – 32 , 35 , 36 , 39 – 44 , 46 – 51 , 56 – 61 ).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, in one patient who had a strangulated hernia, ICG was used to assess the perfusion of the distal and proximal ends before anastomosis. This resulted in further resection to obtain adequately perfused distal and proximal bowel ends prior to the anastomosis ( 35 ).…”

Section: Colon Surgerymentioning

confidence: 99%

“…The time to ICG identification improved after successful revascularization. ICG also served to identify the demarcation of an ischemic toe that was planned for amputation in the same patient ( 35 ).…”

Section: Skin Soft Tissue and Burnsmentioning

confidence: 99%

“…However, ICG angiography is initially useful in assessing gonadal perfusion after detorsion and can potentially affect the operative decision. A summary of pertaining literature on perfusion assessment using ICG is provided in Table 2 ( 35 , 56 , 80 – 92 , 94 , 95 , 97 , 100 , 101 , 103 – 115 ).…”

Section: Less Common Uses Of Icgmentioning

confidence: 99%

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Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature

Khalaf,

Abdelrahman,

El-Menyar

et al. 2024

Front. Surg.

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For decades, indocyanine green (ICG) has been available for medical and surgical use. The indications for ICG use in surgery have expanded where guided surgery directed by fluorescence and near-infrared fluorescent imaging offers numerous advantages. Recently, surgeons have reported using ICG operative navigation in the emergency setting, with fluorescent cholangiography being the most common procedure. The utility of ICG also involves real-time perfusion assessment, such as ischemic organs and limbs. The rising use of ICG in surgery can be explained by the ICG's rapid technological evolution, accuracy, ease of use, and great potential to guide precision surgical diagnosis and management. The review aims to summarize the current literature on the uses of ICG in emergency general surgery. It provides a comprehensive and practical summary of the use of ICG, including indication, route of administration, and dosages. To simplify the application of ICG, we subdivided its use into anatomical mapping and perfusion assessment. Anatomical mapping includes the biliary tree, ureters, and bowel. Perfusion assessment includes bowel, pancreas, skin and soft tissue, and gonads. This review provides a reference to emergency general surgeons to aid in implementing ICG in the emergency setting for more enhanced and safer patient care.

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Section: Resultsmentioning

confidence: 99%

Section: Colon Surgerymentioning

confidence: 99%

Section: Skin Soft Tissue and Burnsmentioning

confidence: 99%

Section: Less Common Uses Of Icgmentioning

confidence: 99%

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Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature

Khalaf,

Abdelrahman,

El-Menyar

et al. 2024

Front. Surg.

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“…In addition to the encapsulation of SPIONs in PLGA employed for diagnostics, near-infrared (NIR) fluorescent dyes are a potential alternative for the diagnosis and excision of residual malignant cancer, which is invisible by conventional visual examination and palpation [16][17][18]. Indocyanine green is the only NIR dye permitted for clinical use [19]. Dyes such as IR780 and IR783 are also promising diagnostic choices.…”

Section: Introductionmentioning

confidence: 99%

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

Dang-Luong,

Nguyen,

Le-Tuan

et al. 2024

Beilstein J. Nanotechnol.

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Theragnostics has become a popular term nowadays, since it enables both diagnosis and therapy at the same time while only using one carrier platform. Therefore, formulating a nanocarrier system that could serve as theragnostic agent by using simple techniques would be an advantage during production. In this project, we aimed to develop a nanocarrier that can be loaded with the chemotherapeutic medication chlorambucil and magnetic resonance imaging agents (e.g., iron oxide nanoparticles and near-infrared fluorophore IR780) for theragnostics. Poly(lactic-co-glycolic acid) was combined with the aforementioned ingredients to generate poly(vinyl alcohol)-based nanoparticles (NPs) using the single emulsion technique. Then the NPs were coated with F127 and F127-folate by simple incubation for five days. The nanoparticles have the hydrodynamic size of approx. 250 nm with negative charge. Similar to chlorambucil and IR780, iron oxide loadings were observed for all three kinds of NPs. The release of chlorambucil was quicker at pH 5.4 than at pH 7.4 at 37 °C. The F127@NPs and F127-folate@NPs demonstrated much greater cell uptake and toxicity up to 72 h after incubation. Our in vitro results of F127@NPs and F127-folate@NPs have demonstrated the ability of these systems to serve as medication and imaging agent carriers for cancer treatment and diagnostics, respectively.

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The Use of Combined Laser Irradiation of the Intestinal Wall to Assess the Intestines Viability

Grynchuk,

Polyanskyi,

Grynchuk

2024

Khark. Surg. Sch.

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Resume. Aim: to study the informativeness of the scattering indicators of laser beams (LB) with wavelengths λ=0.63 and λ=0.4 µm for assessing the intestinal viability. Material and methods. 20 white rats with small (10 rats) and large (10 rats) intestinal obstruction models. In 6 hours, the intestines were irradiated with LB. After measuring the width of the LB scattering zone, intestinal tissues were taken for histological examination. The examination data of 10 intact rats were the control. Results. The LB width scattering zone increases if viability is disrupted. But absolute parameters have local and individual variability. The use of the parameters ratio of the LB width scattering zone with different wavelengths eliminates this variability. The parameters of the ratio differ significantly, depending on the degree of viability disruption. Conclusions. 1. Morphological changes in the intestinal walls are associated with significant differences in the ratio parameters of the scattering zone width of laser beams with wavelengths of λ=0.63 and λ=0.4 µm. 2. Ratio parameters > 1.58 un are a marker of preserved viability, parameters within 1.4-1.35 un are a marker of morphological disorders without necrosis, parameters < 1.2 un are a marker of necrotic disorders.

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Applications of indocyanine green in surgery: A single center case series

Cited by 6 publications

References 30 publications

Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature

Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

The Use of Combined Laser Irradiation of the Intestinal Wall to Assess the Intestines Viability

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