Applications of high-throughput ‘omics’ data in the study of frailty

Wen, Lu; Xu, Yuewen; Su, Jun; Chong, Cheong-Meng; Su, Huanxing; Luo, Oscar Junhong; Fang, Evandro Fei; Bao, Zhijun; Chen, Guobing

doi:10.1016/j.tma.2019.04.002

Cited by 6 publications

(1 citation statement)

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“…The richness and diversity of gut microbiota are acknowledged health biomarkers, including the frailty of elderly people and some personality traits ( Lei et al., 2019 ; Johnson, 2020 ). Frailer individuals have decreased richness and diversity of gut microbiota ( Jackson et al., 2016 ; Maffei et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Gut Microbiota in Centenarians and Young People: Impact of Eating Habits and Childhood Living Environment

Sepp

Smidt

Rööp

et al. 2022

Front. Cell. Infect. Microbiol.

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The composition of centenarians’ gut microbiota has consistently been used as a model for healthy aging studies. However, there is an incomplete understanding of how childhood living conditions and eating habits affect the development and composition of gastrointestinal microbiota in centenarians with good cognitive functions. We compared the gut microbiota as well as the living and eating habits of the oldest-old group and the young people group. The richness and diversity of microbiota and the abundance of hereditary and environmental microbes were higher in people with longevity than young people. People with longevity ate more potatoes and cereal products. In their childhood, they had more exposure to farm animals and did not have sewers compared with young people. Young people’s gut microbiota contained more butyrate-producing bacteria and bacteria that characterized an animal-based Western diet. These results expand our understanding of the effects of childhood environment and diet on the development and stability of the microbiota in people with longevity.

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