Applications of combinatorial methods in catalysis

Hagemeyer, Alfred; Jandeleit, Bernd; Liu, Yumin; Poojary, Damodara M.; Turner, Howard W.; Volpe, Anthony F.; Weinberg, W. H.

doi:10.1016/s0926-860x(01)00886-9

Cited by 154 publications

(67 citation statements)

References 119 publications

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“…[2][3][4][5][6][7] Particular success has been achieved in polyolefins R&D, [8,9] where HT screening has greatly expanded the volume, scope, and quality of data available, while minimizing total materials consumption relative to conventional benchtop techniques. A major asset in screening prospective polymerization catalysts is the ease of compiling qualitative reaction profiles by using infrared thermography to monitor reaction exotherms in the standard 96-well plate format.…”

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confidence: 99%

“…Volpe and coworkers have pointed out the critical importance of being able to utilize a variety of screening tools to assess product streams. [3] This methodology rests on identification of a HT quenching agent Q suitable for the catalytic reaction under study. We employ a five-stage search process, involving candidate selection; primary screening at high Q levels using a robust, highly active example of the catalyst family under consideration; secondary screening at lower Q ratios; confirmation of rapid annihilation of activity, and validation of the optimal quenching agent by assaying across a broad family of relevant catalysts.…”

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Time as a Dimension in High‐Throughput Homogeneous Catalysis

et al. 2008

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High-throughput screening offers major opportunities to accelerate the discovery and optimization of homogeneously catalyzed reactions. A general method for acquisition of reaction profiles through a high-throughput quenching (HTQ) approach is described, which gives a more accurate picture of catalyst performance, e.g., total productivity, induction periods, selectivity and lifetime, than the customary analysis at a fixed, arbitrary time.

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Time as a Dimension in High‐Throughput Homogeneous Catalysis

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“…By comparing such data to computational fluid dynamics simulations it is possible to obtain the reaction rate as a function of the partial pressures of reactants and products at the catalytic surface. 17 The broad maximum in the O 2 and Ar signals at Z cap ϭ0.6 mm may be due to variation in the total pressure and/or temperature when the quartz tube is moved inside the nose.…”

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confidence: 99%

“…1,2 The objective has been to speed up the discovery process and to lower the development time for new catalysts and materials in general. One example of such an approach is ''scanning mass spectrometry,'' which is performed by integrating gas delivery and spatially resolved gas sampling into a probe that functions over an array of catalysts on a sample plate.…”

Section: Introductionmentioning

confidence: 99%

Combined high-pressure cell–ultrahigh vacuum system for fast testing of model metal alloy catalysts using scanning mass spectrometry

Johansson

Jørgensen

Chorkendorff

2004

Review of Scientific Instruments

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An apparatus for fabrication, surface analysis in ultrahigh vacuum, and testing of the catalytic activity of model metal alloy catalysts is described. Arrays of model catalysts are produced by electron-beam deposition of up to four metals simultaneously onto a substrate. The surface analysis techniques available are scanning electron microscopy, x-ray photoemission spectroscopy, ion scattering spectroscopy, Auger electron spectroscopy, sputter profiling, and temperature programmed desorption. The catalytic activity of the model catalysts is tested individually by scanning a combined gas delivery and gas sampling device over the sample surface. The gas sampled is analyzed with mass spectrometry. Experiments can be made at pressures up to 1 bar and temperatures up to 500 °C. It is shown that the lateral resolution is better than 0.2 mm and that up to 20 circular spots, 1 mm in diameter, can be studied on a substrate 10 mm in diameter. A high pressure cell with an all-metal sealed ultrahigh vacuum lock is also described as part of the work.

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“…[1,2,8,58] Primary screening is qualitative or semiquantitative, characterized by very high throughput, and is most often focused on discovery. Secondary screening is utilized for confirmation of primary screening results, lead optimization, or discovery.…”

Section: Introductionmentioning

confidence: 99%

Application of High Throughput Screening to Heterogeneous Liquid and Gas Phase Oxidation Catalysis

Guram¹,

Hagemeyer²,

Lugmair³

et al. 2004

Adv Synth Catal

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The application of combinatorial methods to oxidation catalysis in the liquid and gas phases is described. New lead materials have been discovered for the selective liquid phase oxidation of alcohols to aldehydes/ketones catalyzed by vanadium supported on carbon, for the low temperature CO oxidation/ light off for cold start automotive emissions control over supported noble metals and perovskites, for volatile organic compound (VOC) removal using CoCr oxide catalysts, and for the selective gas phase oxidation of propane to acrylic acid and acrylonitrile using mixed metal oxides. Catalyst discovery libraries were screened in 96-well batch reactors, in a rapid serial scanning mass spectrometer and in a massively parallel microfluidic reactor as primary screens. Promising hits were scaled up in conventional autoclaves or in multi-channel fixed bed secondary/ tertiary screening reactors.

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Applications of combinatorial methods in catalysis

Cited by 154 publications

References 119 publications

Time as a Dimension in High‐Throughput Homogeneous Catalysis

Time as a Dimension in High‐Throughput Homogeneous Catalysis

Combined high-pressure cell–ultrahigh vacuum system for fast testing of model metal alloy catalysts using scanning mass spectrometry

Application of High Throughput Screening to Heterogeneous Liquid and Gas Phase Oxidation Catalysis

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